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Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study
Vanessa M. Young, Rebecca Bernal, Andrée‐Ann Baril, Joy Zeynoun, Crystal Wiedner, Carlos A. Gaona, Alexa Beiser, Antônio Lúcio Teixeira et al.. Alzheimer s & Dementia, 2025-04-01
Topic: Risk, prevention and care in population studies
Long sleep was associated with reduced overall cognitive function (β ± standard error = -0.25 ± 0.07, p < 0.001), with strongest effects in those with depressive symptoms using (-0.74 ± 0.30, p = 0.017) and not using antidepressants (-0.60 ± 0.26, p = 0.024). Weaker but significant effects were observed in those without depressive symptoms (-0.18 ± 0.09, p = 0.044). No significant associations were observed in participants using antidepressants without depressive symptoms. Associations between sleep duration and cognitive performance are strongest in individuals with depressive symptoms, regardless of antidepressant use. Future research should elucidate underlying mechanisms and temporal relationships. HIGHLIGHTS: Sleeping ≥ 9 hours/night was associated with worse cognitive performance. This association was stronger among those with depression. Long sleepers were more likely to report symptoms of depression. Sleep may be a modifiable risk for cognitive decline in people with depression.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Young, V. M., Bernal, R., Baril, A., Zeynoun, J., Wiedner, C., Gaona, C. A., et al. (2025). Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70160
Vancouver
Young VM, Bernal R, Baril A, Zeynoun J, Wiedner C, Gaona CA, et al. Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70160. PMID: 40257009.
BibTeX
@article{young2025-40257009,
author = {Young, Vanessa M. and Bernal, Rebecca and Baril, Andrée‐Ann and Zeynoun, Joy and Wiedner, Crystal and Gaona, Carlos A. and Beiser, Alexa and Teixeira, Antônio Lúcio and others},
title = {{Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70160},
pmid = {40257009},
url = {https://doi.org/10.1002/alz.70160}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Long sleep was associated with reduced overall cognitive function (β ± standard error = -0.25 ± 0.07, p < 0.001), with strongest effects in those with depressive symptoms using (-0.74 ± 0.30, p = 0.017) and not using antidepressants (-0.60 ± 0.26, p = 0.024).
- Weaker but significant effects were observed in those without depressive symptoms (-0.18 ± 0.09, p = 0.044).
- No significant associations were observed in participants using antidepressants without depressive symptoms.
- Associations between sleep duration and cognitive performance are strongest in individuals with depressive symptoms, regardless of antidepressant use.
- Future research should elucidate underlying mechanisms and temporal relationships.
Why it matters
In a cross-sectional Framingham Heart Study analysis, sleeping 9 or more hours a night was associated with worse cognitive performance, and this link was strongest in people with depressive symptoms. Because it is cross-sectional, it cannot show whether long sleep causes cognitive decline or whether changing sleep would help.
Study details
- Effect size42.7%
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 16 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 17.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Sudha S. Seshadri: h-index 148 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Boston University: institution h-index 1,456 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40257009) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
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