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37/100

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Cognitive tests and assessment

Topic: Brain proteins, microglia and lab models

Both V3 width and plasma Hcy concentration were negatively correlated with MoCA scores in PD (r=-0.358, P<0.001; r=-0.187, P=0.013, respectively). Receiver operating characteristic (ROC) analysis suggested that V3 width and Hcy were able to discriminate PDD and PD without dementia [area under the curve (AUC) =0.767 and 0.628, respectively], PD-NC and PD with cognitive decline (AUC =0.735 and 0.657, respectively), and PD-NC and PD-MCI (AUC =0.683 and 0.664, respectively). Following an average follow-up period of 31.04±18.84 months, PD-MCI patients with a V3 width ≥6.55 mm were at a 4.085 times higher risk of developing dementia, whereas PD-NC patients with a V3 width ≥5.75 mm had nearly double the risk of progressing to MCI. However, baseline plasma Hcy levels were unsuitable to predict cognition alternation over time. Plasma Hcy level and V3 width are associated with cognition function severity in PD patients, a V3 width is an independent predictor of MCI-dementia conversion in PD.

Key findings

Both V3 width and plasma Hcy concentration were negatively correlated with MoCA scores in PD (r=-0.358, P<0.001; r=-0.187, P=0.013, respectively).
Receiver operating characteristic (ROC) analysis suggested that V3 width and Hcy were able to discriminate PDD and PD without dementia [area under the curve (AUC) =0.767 and 0.628, respectively], PD-NC and PD with cognitive decline (AUC =0.735 and 0.657, respectively), and PD-NC and PD-MCI (AUC =0.683 and 0.664, respectively).
Following an average follow-up period of 31.04±18.84 months, PD-MCI patients with a V3 width ≥6.55 mm were at a 4.085 times higher risk of developing dementia, whereas PD-NC patients with a V3 width ≥5.75 mm had nearly double the risk of progressing to MCI.
However, baseline plasma Hcy levels were unsuitable to predict cognition alternation over time.
Plasma Hcy level and V3 width are associated with cognition function severity in PD patients, a V3 width is an independent predictor of MCI-dementia conversion in PD.

Why it matters

In Parkinson's disease patients, wider third ventricle width and higher plasma homocysteine were linked to worse cognition, and a wider third ventricle predicted conversion from mild cognitive impairment to dementia. Baseline homocysteine levels were not suitable for predicting cognitive change over time.

Study details

Effect sizeAUC =0.735; AUC =0.683
Evidence strengthLow

How this study scored 37/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Quantitative Imaging in Medicine and Surgery)
Journal's citation record	0 / 4	Quantitative Imaging in Medicine and Surgery: journal h-index 67 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Wen He: h-index 13 (OpenAlex, whole career)
Institution's track record	0 / 3	Capital Medical University: institution h-index 643 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40235770)
Free to read	2 / 2	Free to read
Total	37 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Hou, C., Zhang, V. W., Li, F.-X., Li, S., Yang, L., Ma, H.-Y., et al. (2025). Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson’s disease with cognitive impairment and their potential to predict conversion to dementia. Quantitative Imaging in Medicine and Surgery. https://doi.org/10.21037/qims-24-1736

Vancouver

Hou C, Zhang VW, Li F.-X, Li S, Yang L, Ma H.-Y, et al. Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson’s disease with cognitive impairment and their potential to predict conversion to dementia. Quantitative Imaging in Medicine and Surgery. 2025. doi:10.21037/qims-24-1736. PMID: 40235770.

BibTeX

@article{hou2025-40235770,
  author  = {Hou, Chao and Zhang, Victor Wei and Li, Fang-Xian and Li, Shuo and Yang, Lizhi and Ma, Hui-Yu and Nie, Fang and Wang, Xue-Mei and others},
  title   = {{Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson’s disease with cognitive impairment and their potential to predict conversion to dementia}},
  journal = {Quantitative Imaging in Medicine and Surgery},
  year    = {2025},
  doi     = {10.21037/qims-24-1736},
  pmid    = {40235770},
  url     = {https://doi.org/10.21037/qims-24-1736}
}

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