Newest studies

Vasomechanic treatment increases efflux of human brain proteins

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: An age-related decline in vasodilation mediated by neurovascular nitric oxide (NO) and vasoconstriction driven by the Piezo1 receptor precede the aggregation of soluble brain proteins such as amyloid-β (Aβ), which then causes further disruption of brain solute homeostasis, ultimately leading to neurodegeneration in Alzheimer’s disease.

• Treatments

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

White Matter Hyperintensities in Behavioral Variant Frontotemporal Dementia and Semantic Variant Primary Progressive Aphasia

43/100 ✓ Peer-reviewed Vascular contributions Neurology Open Access

Key finding: hexanucleotide repeat expansions (HRE) and WMH in bvFTD patients. bvFTD and svPPA are associated with elevated WMH burden independent of CVRF. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Cognitive–exercise dual-task training delays natural aging/d-galactose-induced cognitive decline in mice

33/100 ✓ Peer-reviewed Prevention trials Cellular & Molecular Biology Letters

Key finding: Age-related upregulation in microRNA (miR)-204 and downregulation in long noncoding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) were observed to disrupt Ephrin-B1 (EFNB1)/EphB2 interactions, leading to reduced cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway activation. +4 more findings

• Lifestyle

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Artificial microRNAs targeting tau enable post-symptomatic functional recovery in aged tauopathy mice

30/100 ✓ Peer-reviewed Disease mechanisms Molecular Therapy — Nucleic Acids

Key finding: Our findings highlight the potential of spatially targeted RNA-based tau-lowering strategies for late-stage intervention in tauopathies, addressing a critical unmet need in the treatment of these devastating disorders.

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Neuroinflammation and blood–brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications

45/100 ✓ Peer-reviewed Inflammation and the immune system European journal of medical research

Key finding: Accumulating evidence has revealed that the pathogenesis of CSVD is multifactorial, with neuroinflammation and blood-brain barrier (BBB) dysfunction emerging as central pathological processes. +1 more finding

• Brain Biology
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

From Evasion to Collapse: The Kinetic Cascade of TDP-43 and the Failure of Proteostasis

36/100 ✓ Peer-reviewed Brain tissue and pathology International Journal of Molecular Sciences

Key finding: Disruptions to core ubiquitin-proteasome system (UPS) subunits impede efficient processing, contributing to the clearance failure of misfolded TDP-43 monomers. +4 more findings

• Brain Biology

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Psychological Profiles and Resilience in Family Caregivers of People with Dementia: A Latent Profile Analysis

37/100 ✓ Peer-reviewed Cognitive tests and assessment Psychiatry International

Key finding: LPA supported a three-profile solution: (1) lower depressive symptoms with moderate anxiety (33%), (2) severe combined depression and anxiety (18%) and (3) moderately severe depression with severe anxiety (49%). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Cognitive changes and emotional heart rate variability dynamics in subjective cognitive decline: An exploratory longitudinal neuropsychophysiological study

47/100 ✓ Peer-reviewed Mild cognitive impairment Acta Psychologica

Key finding: At the group level, no significant changes in cognitive performance or HRV indices were observed over time. +3 more findings

• Early Stage

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Facilitating the Measurement and Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) and Understanding Caregiver Burden Using Wearable Devices in Rural Taiwan – Protocol for a Dyadic Feasibility Pilot Study

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety medRxiv

Key finding: Wearable devices may facilitate the measurement and treatment of specific BPSD, as well as reduce caregiver burden. +1 more finding

• Treatments
• Digital Tools
• Caregiving

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina

48/100 ✓ Peer-reviewed Inflammation and the immune system Nature communications

Key finding: These findings support a disease-amplifying role for Chlamydia pneumoniae and propose NLRP3-attenuation or antibiotic-based early interventions.

• Brain Biology

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Serum phosphorylated tau 217 in GBA1 variant carriers with and without Parkinson disease

45/100 ✓ Peer-reviewed Biomarkers Journal of Parkinson's disease

Key finding: We evaluated levels of serum phosphorylated tau 217 (p-tau217) in samples from 29 GBA1-PD, 32 idiopathic PD, 20 non-manifesting GBA1 variant carriers (GBA1-NMC) and 31 healthy controls. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease

41/100 ✓ Peer-reviewed Brain tissue and pathology Fluids and Barriers of the CNS

Key finding: Control and LOAD hiPSCs exhibited comparable efficiency in forming brain capillary endothelial-like cells (BCECs). +4 more findings

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The Icelandic Mutation in the Murine APP Gene, mAPPA673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model

34/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Integrative Neuroscience

Key finding: We found a moderate yet significant reduction in Aβ plaque size in male 5×FAD × mAPPA673T compared with 5×FAD mice. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Human-Centered Ambient and Wearable Sensing for Automated Monitoring in Dementia Care: A Scoping Review

39/100 ✓ Peer-reviewed Digital health tools IEEE Internet of Things Journal

Key finding: We conducted a scoping review to map the rapidly evolving landscape of wearable and ambient sensing technologies for monitoring people with dementia across home and institutional settings. +3 more findings

• Digital Tools

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The effects of a mobile application-based dementia care intelligent recommender system on caregivers of people with dementia: a randomized controlled trial

44/100 ✓ Peer-reviewed Caregiving Age and Ageing

Key finding: The caregivers in intervention group showed significant reductions in distress scores for dressing, personal hygiene, communication, and behavioural and psychological care problems at both the 6th and 12th week assessments. +4 more findings

• Clinical Trials
• Caregiving

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Subtracting First Principal Component May Improve 4R Tau Detectability on [ 18 F]Flortaucipir Tau PET

42/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine

Key finding: Area under the receiver operating characteristic curves differentiating PSP and controls were improved by PC1 subtraction in the frontal white matter (0.54 to 0.67; P = 0.002) and subcortical (0.69 to 0.87; P < 0.001) regions. +3 more findings

• Brain Scans

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Copathologies of Limbic-Predominant Age-Related TDP-43 Encephalopathy and Alzheimer Disease: [ 18 F]FDG PET Statistical Mapping and Quantitative MRI Volumetry

46/100 ✓ Peer-reviewed Biomarkers Journal of Nuclear Medicine

Key finding: Of the 944 clinical cases, 13.0% were characterized as probable LATE (2.4% pure LATE and 10.6% LATE+AD) and 23.7% were characterized as probable AD without LATE. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Characterising Informal Care in Older Individuals Receiving Long‐Term Home Care Support: A National Epidemiological Study

49/100 ✓ Peer-reviewed Risk factors Australasian Journal on Ageing

Key finding: Overall, 233,567 long-term home care recipients with known carer status were studied. +4 more findings

• Caregiving
• Care Services

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Prioritizing perioperative organ injury prevention: a call to action from China's county-level hospitals

38/100 ✓ Peer-reviewed Risk factors Frontiers in Medicine

Key finding: The burden of perioperative organ injury in China is significant even at a national level. +4 more findings

• Prevention
• Care Services

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Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystatin-c activation of TREM2

48/100 ✓ Peer-reviewed Laboratory science Cell

Key finding: Epidemiological data indicate that the incidence of AD significantly decreases in patients with a history of cancer. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Cross-sectional and longitudinal associations between sleep disturbances and psycho-affective symptoms in older adults: influence of amyloid positivity

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: In cognitively unimpaired older adults, associations between sleep disturbances and psycho-affective symptoms differ according to Aβ status. +1 more finding

• Lifestyle

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Measurement of tau protein and Aβ amyloid plaques in postmortem human brains of Down syndrome and Alzheimer’s disease by using [ 125 I]IPPI and [ 125 I]IBETA autoradiography

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: With anti-tau and anti-Aβ immunostains confirming the presence of tau and Aβ plaques, [ 125 I]IPPI and [ 125 I]IBETA binding in autoradiographic images were significantly higher in DSAD and AD gray matter (GM) compared to CN. +2 more findings

• Brain Biology
• Down Syndrome

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

[Neurology : what's new in 2025]

45/100 ✓ Peer-reviewed Biomarkers Revue medicale suisse

Key finding: Bruton tyrosine kinase inhibitors have expanded the therapeutic arsenal for multiple sclerosis. +4 more findings

• Treatments

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Aquaporin-4 deficiency induced white matter injury via upregulated complement component 3 in cerebral small vessel disease

35/100 ✓ Peer-reviewed Vascular contributions Journal of Neuroinflammation

Key finding: We identified four SNPs (rs335929, rs335930, rs335931 and rs455671) were significantly associated with CSVD presence. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cerebellar volumes’ selective association with MoCA over MMSE: a diagnostic insight into mild cognitive impairment and mild dementia

32/100 ✓ Peer-reviewed Cognitive tests and assessment Neurological Sciences

Key finding: MoCA scores showed significant positive correlations with cognitive-related cerebellar regions, particularly the left Crus I lobule (r = 0.40, p = 0.02) and total Crus I volume (r = 0.36, p = 0.04). +2 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source