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Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study
Jacqueline Josephine Claus, Mathijs T. Rosbergen, Jeremy Alexander Labrecque, Meike Willemijn Vernooij, Frank J. Wolters, M. Arfan Ikram. Neurology, 2025-05-09
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
value = 0.04). ε4 on cognition is mediated by structural brain imaging markers, driven mainly by cerebral microbleeds. For dementia, mediation by these markers was limited.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Claus, J. J., Rosbergen, M. T., Labrecque, J. A., Vernooij, M. W., Wolters, F. J., & Ikram, M. A. (2025). Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study. Neurology. https://doi.org/10.1212/wnl.0000000000213679
Vancouver
Claus JJ, Rosbergen MT, Labrecque JA, Vernooij MW, Wolters FJ, Ikram MA. Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study. Neurology. 2025. doi:10.1212/wnl.0000000000213679. PMID: 40344552.
BibTeX
@article{claus2025-40344552,
author = {Claus, Jacqueline Josephine and Rosbergen, Mathijs T. and Labrecque, Jeremy Alexander and Vernooij, Meike Willemijn and Wolters, Frank J. and Ikram, M. Arfan},
title = {{Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study}},
journal = {Neurology},
year = {2025},
doi = {10.1212/wnl.0000000000213679},
pmid = {40344552},
url = {https://doi.org/10.1212/wnl.0000000000213679}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- value = 0.04). ε4 on cognition is mediated by structural brain imaging markers, driven mainly by cerebral microbleeds.
- For dementia, mediation by these markers was limited.
Why it matters
This analysis found that the effect of APOE ε4 on cognition was mediated by structural brain imaging markers, mainly cerebral microbleeds, while mediation by these markers was limited for dementia. It helps explain how a known genetic risk factor relates to cognition but does not offer a treatment or cure.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40344552) |
| Free to read | 2 / 2 | Free to read |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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