This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Getting a diagnosis

Topic: Risk, prevention and care in population studies

Plain-language summary

Dementia risk was significantly higher in patients with epilepsy compared with that of controls (IRR: 3.65; 95% CI: 3.14-4.24), especially within the first 2 years post-diagnosis (aHR: 5.42; 95% CI: 4.30-6.83), peaking between 8 and 10 years (aHR: 8.25; 95% CI: 3.15-21.5). Younger patients (<60 years) were at higher risk, particularly during the first 2 years (aHR: 12.32 vs. 4.70). Men exhibited a greater risk than women in the initial 2 years post-diagnosis (aHR: 6.64 vs. 4.57). The risk of dementia in patients with epilepsy varies with time since diagnosis, age, and sex. Early cognitive assessment and targeted interventions, particularly in younger male patients, are crucial to reduce the long-term burden of dementia. These results provide critical insight for clinicians and public health strategists to enhance the care of patients with epilepsy.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Bae, Y., Kang, C., Choi, U., Jung, H., & Lee, S. W. (2025). Time-Dependent Risk of Dementia Following Epilepsy Diagnosis: A Nationwide Cohort Study in South Korea. Archives of Clinical Neuropsychology. https://doi.org/10.1093/arclin/acaf047

Vancouver

Bae Y, Kang C, Choi U, Jung H, Lee SW. Time-Dependent Risk of Dementia Following Epilepsy Diagnosis: A Nationwide Cohort Study in South Korea. Archives of Clinical Neuropsychology. 2025. doi:10.1093/arclin/acaf047. PMID: 40455643.

BibTeX

@article{bae2025-40455643,
  author  = {Bae, Youngoh and Kang, Chaeyoon and Choi, Unbi and Jung, Hohyun and Lee, Seung Won},
  title   = {{Time-Dependent Risk of Dementia Following Epilepsy Diagnosis: A Nationwide Cohort Study in South Korea}},
  journal = {Archives of Clinical Neuropsychology},
  year    = {2025},
  doi     = {10.1093/arclin/acaf047},
  pmid    = {40455643},
  url     = {https://doi.org/10.1093/arclin/acaf047}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

How to read this study

Design: this is a follow-up (cohort) study. People are observed over time and not assigned to anything, so an association can reflect other differences between groups. Look at how long follow-up lasted, how many dropped out, and whether the authors adjusted for age, education and other health conditions.
Size: the record lists 2,740 participants. Ask whether that is enough for the question, and who they were.
Effect: the record reports “RR: 3.65; aHR: 5.42; aHR: 8.25”. A statistically significant result can still be small in daily life.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

Dementia risk was significantly higher in patients with epilepsy compared with that of controls (IRR: 3.65; 95% CI: 3.14-4.24), especially within the first 2 years post-diagnosis (aHR: 5.42; 95% CI: 4.30-6.83), peaking between 8 and 10 years (aHR: 8.25; 95% CI: 3.15-21.5).
Younger patients (<60 years) were at higher risk, particularly during the first 2 years (aHR: 12.32 vs. 4.70).
Men exhibited a greater risk than women in the initial 2 years post-diagnosis (aHR: 6.64 vs. 4.57).
The risk of dementia in patients with epilepsy varies with time since diagnosis, age, and sex.
Early cognitive assessment and targeted interventions, particularly in younger male patients, are crucial to reduce the long-term burden of dementia.

Why it matters

This nationwide cohort study found that people with epilepsy had a higher risk of dementia, especially in the first two years after diagnosis and among younger patients. The findings suggest early cognitive assessment, but do not provide a treatment, cure, or prevention.

New to this subject? Start with our plain-English guide: Getting a diagnosis →

Study details

Study designcohort study
Participants2,740
Effect sizeRR: 3.65; aHR: 5.42; aHR: 8.25
Evidence strengthModerate

How this study scored 53/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Archives of Clinical Neuropsychology)
Journal's citation record	2 / 4	Archives of Clinical Neuropsychology: journal h-index 151 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	2,740 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Seung Won Lee: h-index 74 (OpenAlex, whole career)
Institution's track record	1 / 3	Sungkyunkwan University: institution h-index 788 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40455643)
Free to read	0 / 2	Behind a paywall — scores zero
Total	53 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Getting a diagnosis from nearby years

Also tagged “biobank”

1,084 studies in the library carry the topic tag “biobank”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,084 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Getting a diagnosis

See all studies in Getting a diagnosis →