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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. How common it is

Topic: Risk, prevention and care in population studies

Background The association between transient ischemic attack (TIA) and dementia is incompletely characterized. Determining the cognitive sequalae of TIA is important as it can function as an early warning sign or additional risk factor for dementia. We sought to determine the long‐term incidence of post‐TIA dementia and examined whether TIA prompts changes in vascular risk factors. Methods Nested matched longitudinal cohort study within the community‐based Framingham Heart Study. A prospectively collected sample of participants without dementia or transient ischemic attack were matched on age and sex (5:1) to participants with first incident TIA >60 years. The primary outcome of interest was the 20‐year incidence of all‐cause dementia. Results The study matched 297 participants with TIA, 141 (47%) men, mean age 72.7±7.7 years, with 1485 controls without TIA. People with TIA were more likely to have hypertension, coronary heart disease, and atrial fibrillation. Over a median of 8.9 years of follow up, 57 (19%) participants with TIA and 353 (24%) controls without TIA developed dementia (hazard ratio [HR], 0.93 [95% CI, 0.71–1.24], P =0.63). Adjusting for stroke and accounting for the competing risk of death did not alter this association. Participants with TIA were more likely to have a reduction in the frequency of smoking (18% to 11%, P =0.025), an increase in anticoagulant use from 3% to 18%, ( P =0.0005), and a marginal increase in aspirin use (46% to 61%, P =0.052). Conclusions We found no significant difference in dementia incidence over a 20‐year follow‐up period compared with matched TIA‐free controls. Our findings suggest that TIA prompts treatment changes and behavioral shifts that lower cardiovascular risk. Whether these are sufficient to mitigate subsequent dementia risk remains to be tested in prospective randomized studies.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Lioutas, V., Peloso, G. M., Romero, J. R., Aparicio, H. J., Gonzales, M. M., Werry, A. E., et al. (2025). Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study. Journal of the American Heart Association. https://doi.org/10.1161/jaha.124.037817

Vancouver

Lioutas V, Peloso GM, Romero JR, Aparicio HJ, Gonzales MM, Werry AE, et al. Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study. Journal of the American Heart Association. 2025. doi:10.1161/jaha.124.037817. PMID: 40611491.

BibTeX

@article{lioutas2025-40611491,
  author  = {Lioutas, Vasileios‐Arsenios and Peloso, Gina Marie and Romero, Jose Rafael and Aparicio, Hugo Javier and Gonzales, Mitzi M. and Werry, Amy E. and Himali, Dibya and Himali, Jayandra Jung and others},
  title   = {{Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study}},
  journal = {Journal of the American Heart Association},
  year    = {2025},
  doi     = {10.1161/jaha.124.037817},
  pmid    = {40611491},
  url     = {https://doi.org/10.1161/jaha.124.037817}
}

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Key findings

Results The study matched 297 participants with TIA, 141 (47%) men, mean age 72.7±7.7 years, with 1485 controls without TIA.
Conclusions We found no significant difference in dementia incidence over a 20‐year follow‐up period compared with matched TIA‐free controls.
Our findings suggest that TIA prompts treatment changes and behavioral shifts that lower cardiovascular risk.

Why it matters

This cohort study found no significant difference in dementia incidence over 20 years between people who had a transient ischemic attack and matched controls without one. The authors suggest that transient ischemic attack prompts treatment changes and behavioral shifts that lower cardiovascular risk.

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Study details

Study designcohort study
Participants297
Evidence strengthHigh

How this study scored 56/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of the American Heart Association)
Journal's citation record	2 / 4	Journal of the American Heart Association: journal h-index 200 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	297 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Sudha S. Seshadri: h-index 148 (OpenAlex, whole career)
Institution's track record	1 / 3	Boston University: institution h-index 1,456 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40611491)
Free to read	2 / 2	Free to read
Total	56 / 100	—

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