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Is US residence a risk factor for Alzheimer's disease?
Høilund-Carlsen Poul F, Alavi Abass, Costa Tommaso, Neve Rachael L, Perry George, Revheim Mona-Elisabeth, Barrio Jorge R. Journal of Alzheimer's disease : JAD, 2025-07-04
Topic: Amyloid, tau and blood-test diagnosis
Reducing risk factors is a useful way to counteract diseases. The prevalence of Alzheimer's disease (AD) in the US is often quoted as 6.9 million out of 333 million people, or 2.1%. It is around 0.7% in the UK, 0.9% in Denmark, and worldwide the estimate is 0.5%. Alongside risk factor reduction, the Centers for Medicare and Medicaid Services could strengthen the US fight against AD by reconsidering its October 2023 decision to liberalize reimbursement of amyloid PET scans, or better yet, advise replacing these non-specific scans with FDG-PET, which shows what AD is really about: impaired regional brain function.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Høilund-Carlsen Poul, F., Abass, A., Tommaso, C., Neve Rachael, L., George, P., Mona-Elisabeth, R., et al. (2025). Is US residence a risk factor for Alzheimer's disease? Journal of Alzheimer's disease : JAD. https://doi.org/10.1177/13872877251356682
Vancouver
Høilund-Carlsen Poul F, Abass A, Tommaso C, Neve Rachael L, George P, Mona-Elisabeth R, et al. Is US residence a risk factor for Alzheimer's disease? Journal of Alzheimer's disease : JAD. 2025. doi:10.1177/13872877251356682. PMID: 40611639.
BibTeX
@article{hoilundcarlsenpoul2025-40611639,
author = {Høilund-Carlsen Poul, F. and Abass, Alavi and Tommaso, Costa and Neve Rachael, L. and George, Perry and Mona-Elisabeth, Revheim and Barrio Jorge, R.},
title = {{Is US residence a risk factor for Alzheimer's disease?}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2025},
doi = {10.1177/13872877251356682},
pmid = {40611639},
url = {https://doi.org/10.1177/13872877251356682}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Reducing risk factors is a useful way to counteract diseases.
- The prevalence of Alzheimer's disease (AD) in the US is often quoted as 6.9 million out of 333 million people, or 2.1%.
- It is around 0.7% in the UK, 0.9% in Denmark, and worldwide the estimate is 0.5%.
- Alongside risk factor reduction, the Centers for Medicare and Medicaid Services could strengthen the US fight against AD by reconsidering its October 2023 decision to liberalize reimbursement of amyloid PET scans, or better yet, advise replacing these non-specific scans with FDG-PET, which shows what AD is really about: impaired regional brain function.
Why it matters
This commentary discusses differences in quoted Alzheimer's disease prevalence between the US and other countries and suggests risk factor reduction and reconsidering reimbursement of amyloid PET scans. It is an opinion piece and does not report new evidence on treating, curing, or preventing the disease.
Study details
- Effect sizeor 2.1; 0.7%; 0.9%
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 37 of the 94 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jorge R. Barrio: h-index 71 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Massachusetts General Hospital: institution h-index 2,057 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40611639) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 37 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 37 of the 94 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
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