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Incidence and Risk of Stroke following Dementia: A Nationwide Cohort Study in South Korea
Chaeyoon Kang, Seung Won Lee, Hohyun Jung, Youngoh Bae. Dementia and Geriatric Cognitive Disorders, 2025-11-04
Topic: Risk, prevention and care in population studies
During a mean follow-up of 2.49 years (median, 1.99; standard deviation, 2.07; interquartile range, 2.66), dementia was significantly associated with increased stroke risk (aHR, 3.19; 95% confidence interval, 2.84-3.57). The highest risk was observed in patients with vascular dementia (VaD; aHR, 3.58), followed by Alzheimer's disease (AD; aHR, 2.73) and other dementias (aHR, 2.61). Ischemic stroke (IS) was more common than hemorrhagic stroke (HS) across all subtypes. The relative risk was greater in individuals aged <60 years and in males with AD or other dementias, whereas sex differences were not evident in VaD. Dementia, especially VaD, is a strong risk factor for both IS and HS. These findings support the need for dementia subtype-specific cerebrovascular risk assessment and long-term prevention strategies.
Key findings
- During a mean follow-up of 2.49 years (median, 1.99; standard deviation, 2.07; interquartile range, 2.66), dementia was significantly associated with increased stroke risk (aHR, 3.19; 95% confidence interval, 2.84-3.57).
- The highest risk was observed in patients with vascular dementia (VaD; aHR, 3.58), followed by Alzheimer's disease (AD; aHR, 2.73) and other dementias (aHR, 2.61).
- Ischemic stroke (IS) was more common than hemorrhagic stroke (HS) across all subtypes.
- The relative risk was greater in individuals aged <60 years and in males with AD or other dementias, whereas sex differences were not evident in VaD.
- Dementia, especially VaD, is a strong risk factor for both IS and HS.
Why it matters
This nationwide cohort study in South Korea found that people with dementia had a significantly increased risk of stroke, with the highest risk in vascular dementia. The authors call for dementia subtype-specific cerebrovascular risk assessment and long-term prevention strategies.
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Study details
- Study designcohort study
- Participants2,820
- Evidence strengthModerate
How this study scored 49/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Dementia and Geriatric Cognitive Disorders) |
| Journal's citation record | 1 / 4 | Dementia and Geriatric Cognitive Disorders: journal h-index 149 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,820 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Youngoh Bae: h-index 9 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Sungkyunkwan University: institution h-index 788 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41187102) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
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Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Kang, C., Lee, S. W., Jung, H., & Bae, Y. (2025). Incidence and Risk of Stroke following Dementia: A Nationwide Cohort Study in South Korea. Dementia and Geriatric Cognitive Disorders. https://doi.org/10.1159/000549405
Vancouver
Kang C, Lee SW, Jung H, Bae Y. Incidence and Risk of Stroke following Dementia: A Nationwide Cohort Study in South Korea. Dementia and Geriatric Cognitive Disorders. 2025. doi:10.1159/000549405. PMID: 41187102.
BibTeX
@article{kang2025-41187102,
author = {Kang, Chaeyoon and Lee, Seung Won and Jung, Hohyun and Bae, Youngoh},
title = {{Incidence and Risk of Stroke following Dementia: A Nationwide Cohort Study in South Korea}},
journal = {Dementia and Geriatric Cognitive Disorders},
year = {2025},
doi = {10.1159/000549405},
pmid = {41187102},
url = {https://doi.org/10.1159/000549405}
}
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