Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,951–26,975 of 27,380 studies, newest first · page 1079 of 1096.
May 1991 2
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1991-05-01
Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues
36/100 ✓ Peer-reviewed Drug development Laboratory investigation; a journal of technical methods and pathology
Key finding: In previous studies on normal tau distribution, different optimized fixations that effectively preserve tau antigenicity were used but none of these revealed all of these compartments together. +1 more finding
Full summary, score breakdown and related studies → Original source
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1991-05-01
Apolipoprotein E genotyping by one-stage PCR
47/100 ✓ Peer-reviewed Risk genes beyond APOE The Lancet
Full summary, score breakdown and related studies → Original source
April 1991 7
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1991-04-01
A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline
36/100 ✓ Peer-reviewed Vascular contributions NMR in biomedicine
Key finding: NAA is elevated in several degenerative neurological conditions including amyotrophic lateral sclerosis and canavan disease, and in high concentrations it may behave like a neurotoxin. +4 more findings
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1991-04-01
The molecular pathology of Alzheimer's disease
54/100 ✓ Peer-reviewed Disease mechanisms Neuron
Full summary, score breakdown and related studies → Original source
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1991-04-01
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
61/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: The Neuropathology Task Force of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) has developed a practical and standardized neuropathology protocol for the postmortem assessment of dementia and control subjects. +4 more findings
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1991-04-01
How old are the elderly?
27/100 ✓ Peer-reviewed Health systems and care delivery The British Journal of Psychiatry
Key finding: Contrary to the experience at the Crichton Royal, our major difficulty is providing in-patient beds for the functionally ill, which again may be a local problem.
Full summary, score breakdown and related studies → Original source
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1991-04-01
Characteristics of age-related language decline in adults with Down syndrome
34/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Mental retardation
Key finding: Our results showed significant relations between aging and language comprehension and aging and self-help skills. +1 more finding
Full summary, score breakdown and related studies → Original source
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1991-04-01
Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity
48/100 ✓ Peer-reviewed Disparities Brain : a journal of neurology
Key finding: We conclude that the presence of ubiquitin-IR inclusions in lower motor neurons represents a characteristic pathological feature of ALS in its various clinical forms.
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1991-04-01
Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging
50/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: These findings indicate that even "questionable" dementia can be diagnostic for Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
March 1991 7
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1991-03-01
Advances in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms The FASEB Journal
Key finding: But in the past several years there have been significant extensions of our knowledge of the disease and advances in determining the molecular changes underlying the disorder.
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1991-03-01
Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions
40/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Clinical Investigation
Key finding: LT was associated with CD3+ lymphocytes and Leu-M5+ microglia cells at the lesion edge and to a lesser extent, in adjacent white matter. +2 more findings
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1991-03-01
Advance directives for medical care--a case for greater use
41/100 ✓ Peer-reviewed Getting a diagnosis The New England journal of medicine
Key finding: When people are asked to imagine themselves incompetent with a poor prognosis, they decide against life-sustaining treatments about 70 percent of the time.
Full summary, score breakdown and related studies → Original source
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1991-03-01
Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures
36/100 ✓ Peer-reviewed Risk factors Archives of neurology
Key finding: The test for delayed recall was found to be the best overall discriminatory measure. +2 more findings
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1991-03-01
Visual impairment and cognitive dysfunction in Alzheimer's disease
50/100 ✓ Peer-reviewed Risk factors Journal of general internal medicine
Key finding: Visual impairment is associated with both an increased risk and an increased clinical severity of Alzheimer's disease, but the increased risk may not be consistent with a progressive dose-response relationship. +4 more findings
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1991-03-01
Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles
36/100 ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America
Key finding: The antigenic changes in E-NFTs suggest that when NFTs become extracellular they lose the N and, possibly, the C termini of tau while maintaining the intermediate region of the molecule; they also lose the N-terminal two-thirds of Ub while the C-terminal conjugation site of Ub is preserved. +1 more finding
Full summary, score breakdown and related studies → Original source
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1991-03-01
Expression of the amyloid precursor protein gene in mouse oocytes and embryos
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: Screens for APP clones in embryonic cDNA libraries from the egg cylinder stage and the early somite stage were used to confirm the results of the polymerase chain reaction, and APP clone abundance was found to increase 10-fold between the two stages.
Full summary, score breakdown and related studies → Original source
February 1991 9
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1991-02-21
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
63/100 ✓ Peer-reviewed Genetics Nature
Key finding: In this kindred, which shows linkage to chromosome 21 markers, there is a point mutation in the APP gene. +2 more findings
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1991-02-01
Marked cerebrospinal fluid void: indicator of successful shunt in patients with suspected normal-pressure hydrocephalus
43/100 ✓ Peer-reviewed Digital health tools Radiology
Key finding: A significant (P less than .003) correlation existed between good or excellent response to surgery and an increased CSF flow void. +1 more finding
Full summary, score breakdown and related studies → Original source
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1991-02-01
The screen for caregiver burden
45/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: Finally, evidence suggests that changes in OB and SB over time are explained by changes in care-recipient functioning and caregiver distress.
Full summary, score breakdown and related studies → Original source
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1991-02-01
Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques
36/100 ✓ Peer-reviewed Drug development The American journal of pathology
Key finding: Here the presence and distribution within senile plaques of various epitopes of the beta-amyloid precursor protein (APP) are compared with the distribution of A beta P itself and markers for plaque neurites. +2 more findings
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1991-02-01
Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status
40/100 ✓ Peer-reviewed Tau biomarkers Annals of neurology
Key finding: CSF concentrations of quinolinic acid were significantly correlated to the severity of the neuropsychological deficits. +1 more finding
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1991-02-01
The cardiovascular health study: Design and rationale
51/100 ✓ Peer-reviewed Long-term cohort studies Annals of Epidemiology
Key finding: The Cardiovascular Health Study (CHS) is a population-based, longitudinal study of coronary heart disease and stroke in adults aged 65 years and older. +3 more findings
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1991-02-01
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
47/100 ✓ Peer-reviewed Brain tissue and pathology Brain Research
Key finding: Apo E immunoreactivity was associated with amyloid in both senile plaques and cerebral vessels and neurofibrillary tangles +2 more findings
Full summary, score breakdown and related studies → Original source
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1991-02-01
The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences
37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain research. Molecular brain research
Key finding: Transfection of these constructs into Hela and PC12 cells revealed the presence of two blocks of regulatory sequences in the APP promoter. +3 more findings
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1991-02-01
Mini-Mental State exam scores vary with education in blacks and whites
60/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Previous studies have suggested that education and race may affect performance on standardized mental status tests. +2 more findings
Full summary, score breakdown and related studies → Original source
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