Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 27,201–27,225 of 27,380 studies, newest first · page 1089 of 1096.
May 1987 2
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1987-05-01
Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles
43/100 ✓ Peer-reviewed Disparities Journal of neuropathology and experimental neurology
Key finding: However, in a large series of cases (60) over age 74 a significant minority (30%) lacked neocortical tangles. +3 more findings
Full summary, score breakdown and related studies → Original source
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1987-05-01
Psychological, social, and health consequences of caring for a relative with senile dementia
42/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: Caregivers reported significantly higher levels of depression and negative affect toward their relatives, and lower overall life satisfaction than controls. +2 more findings
Full summary, score breakdown and related studies → Original source
April 1987 5
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1987-04-01
Clinical assessment of 31 patients with Wilson's disease. Correlations with structural changes on magnetic resonance imaging
36/100 ✓ Peer-reviewed Digital health tools Archives of neurology
Key finding: The three asymptomatic patients had normal scans. +4 more findings
Full summary, score breakdown and related studies → Original source
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1987-04-01
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Journal of the neurological sciences
Key finding: Values of synapse to neurone ratio also demonstrated this greater loss of synapses, there being on average 38% fewer synapses associated with each surviving neurone in layers II-III of the temporal cortex, 30% fewer in layer V, and a deficit of 14% in layer V of the frontal cortex. +1 more finding
Full summary, score breakdown and related studies → Original source
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1987-04-01
Rapid eye movement sleep behavior disorder. A treatable parasomnia affecting older adults
47/100 ✓ Peer-reviewed Brain scans and imaging JAMA
Key finding: All patients underwent standard polysomnographic studies with videotaping of behaviors and extensive neurologic and psychiatric evaluations. +4 more findings
Full summary, score breakdown and related studies → Original source
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1987-04-01
The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Biochemical and biophysical research communications
Key finding: The human amyloid beta protein is the major constituent of the brain amyloid plaques found in Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1987-04-01
Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: Our observations indicate that the brain amyloids of these diseases have a common subunit protein, which would also indicate a common pathogenesis.
Full summary, score breakdown and related studies → Original source
March 1987 2
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1987-03-01
Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Science (New York, N.Y.)
Key finding: With the recently cloned complementary DNA probe, lambda Am4 for the chromosome 21 gene encoding brain amyloid polypeptide (beta amyloid protein) of Alzheimer's disease, leukocyte DNA from three patients with sporadic Alzheimer's disease and two patients with karyotypically normal Down syndrome was found to contain three copies of this gene. +1 more finding
Full summary, score breakdown and related studies → Original source
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1987-03-01
Falls and fractures in patients with Alzheimer-type dementia
52/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: During follow-up, 50% either fell or became unable to walk. +4 more findings
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February 1987 7
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1987-02-20
Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease
41/100 ✓ Peer-reviewed Vascular contributions Science
Key finding: Thus, with age, the amyloid proteins associated with progressive cortical degeneration in Alzheimer's disease are also deposited in the brains of other mammals.
Full summary, score breakdown and related studies → Original source
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1987-02-20
Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease
56/100 ✓ Peer-reviewed Risk genes beyond APOE Science
Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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1987-02-01
Psychotropic drug use and the risk of hip fracture
66/100 ✓ Peer-reviewed Clinical safety The New England journal of medicine
Key finding: To assess the risk of hip fracture associated with the use of four classes of psychotropic drugs, we performed a case-control study of 1021 patients with hip fractures and 5606 controls among elderly Medicaid enrollees. +4 more findings
Full summary, score breakdown and related studies → Original source
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1987-02-01
The genetic defect causing familial Alzheimer's disease maps on chromosome 21
41/100 ✓ Peer-reviewed Risk genes beyond APOE Science (New York, N.Y.)
Key finding: Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. +4 more findings
Full summary, score breakdown and related studies → Original source
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1987-02-01
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
58/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: We have now isolated and sequenced an apparently full-length complementary DNA clone coding for the A4 polypeptide. +2 more findings
Full summary, score breakdown and related studies → Original source
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1987-02-01
The role of astrocytes in hepatic encephalopathy
39/100 ✓ Peer-reviewed Inflammation and the immune system Neurochemical pathology
Key finding: Whether this change is a primary event in the pathogenesis of HE or whether it is secondary to injury of some other component(s) of the CNS has not been clarified. +3 more findings
Full summary, score breakdown and related studies → Original source
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1987-02-01
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
57/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Science (New York, N.Y.)
Key finding: A complementary DNA for the beta protein suggests that it derives from a larger protein expressed in a variety of tissues.
Full summary, score breakdown and related studies → Original source
January 1987 8
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1987-01-01
Stress, appraisal, coping, and social support as predictors of adaptational outcome among dementia caregivers
43/100 ✓ Peer-reviewed Risk factors Psychology and Aging
Key finding: Appraisal, coping responses, and social support and activity were significant predictors of caregiver outcome, even when severity of caregiving stressors was statistically controlled. +1 more finding
Full summary, score breakdown and related studies → Original source
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1987-01-01
Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis)
40/100 ✓ Peer-reviewed Digital health tools Archives of neurology
Key finding: The nine controls with leuko-araiosis had lower scores on the ESD than the 96 controls without leuko-araiosis (mean ESD with leuko-araiosis, 227.1 +/- 14; without leuko-araiosis, 237.1 +/- 8), and the difference remains significant even after adjusting for the possible confounding effects of age, sex, education, and infarct detected on computed tomography. +2 more findings
Full summary, score breakdown and related studies → Original source
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1987-01-01
Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2
36/100 ✓ Peer-reviewed Drug development The American journal of pathology
Key finding: That the proteins are indeed tau and MAP2 is demonstrated by reaction of electroblotted proteins with antibodies raised in mouse and guinea pig against bovine brain tau and MAP2. +2 more findings
Full summary, score breakdown and related studies → Original source
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1987-01-01
Vascular risk factors and leuko-araiosis
47/100 ✓ Peer-reviewed Vascular contributions Archives of neurology
Key finding: Leuko-araiosis was found in 49 of 140 demented patients compared with 12 out of 110 control subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
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1987 no date recorded — placed by publication year
A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
48/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Chronic Diseases
Key finding: A weighted index that takes into account the number and the seriousness of comorbid disease was developed in a cohort of 559 medical patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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1987-01-01
The Clinical Diagnosis of Alzheimer's Disease
54/100 ✓ Peer-reviewed Getting a diagnosis Archives of Neurology
Key finding: Clinical and pathologic diagnoses are compared in 65 patients who had dementia and who had been studied longitudinally during life. +3 more findings
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1987-01-01
Young onset Parkinson's disease
47/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society
Key finding: In neither group have we found any association with prematurely grey hair, hypertension, diabetes, pernicious anaemia, or thyroid disorder.
Full summary, score breakdown and related studies → Original source
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1987-01-01
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles
42/100 ✓ Peer-reviewed Disparities Acta neuropathologica
Key finding: Whereas pretreatment of sections with phosphatase was required for the detection of tangles with Tau-1 monoclonal antibody, digestion of sections with either phosphatase or pronase had no significant effect on the staining pattern obtained with the other antibodies.
Full summary, score breakdown and related studies → Original source
December 1986 1
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1986-12-01
CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia
54/100 ✓ Peer-reviewed Getting a diagnosis The British journal of psychiatry : the journal of mental science
Key finding: A new interview schedule for the diagnosis and measurement of dementia in the elderly is described. +2 more findings
Full summary, score breakdown and related studies → Original source
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