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Apolipoprotein E genotyping by one-stage PCR
Philip R. Wenham, W H Price, Gillian Blundell. The Lancet, 1991-05-01
Topic: Brain proteins, microglia and lab models
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Why it matters
Describes a method for determining apolipoprotein E genotype using one-stage PCR.
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How this study scored 47/100
Published in a top-tier journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 45 of the 95 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (The Lancet) |
| Journal's citation record | 4 / 4 | The Lancet: journal h-index 1,205 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1991 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,072 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 29.0 citations a year over 37 year(s) since 1991 |
| Impact for its field and year | 3 / 6 | Cited 6.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 46 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Gillian Blundell: h-index 17 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Western General Hospital: institution h-index 679 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 1674030) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 45 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 45 of the 95 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Wenham, P. R., Price, W. H., & Blundell, G. (1991). Apolipoprotein E genotyping by one-stage PCR. The Lancet. https://doi.org/10.1016/0140-6736(91)92823-k
Vancouver
Wenham PR, Price WH, Blundell G. Apolipoprotein E genotyping by one-stage PCR. The Lancet. 1991. doi:10.1016/0140-6736(91)92823-k. PMID: 1674030.
BibTeX
@article{wenham1991-1674030,
author = {Wenham, Philip R. and Price, W H and Blundell, Gillian},
title = {{Apolipoprotein E genotyping by one-stage PCR}},
journal = {The Lancet},
year = {1991},
doi = {10.1016/0140-6736(91)92823-k},
pmid = {1674030},
url = {https://doi.org/10.1016/0140-6736(91)92823-k}
}
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