Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,926–26,950 of 27,380 studies, newest first · page 1078 of 1096.
September 1991 5
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1991-09-01
Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1980-1990 prevalence findings. The EURODEM-Prevalence Research Group
40/100 ✓ Peer-reviewed Vascular contributions Annals of neurology
Key finding: Overall European prevalence (per 100 population) for the age groups 30 to 59, 60 to 69, 70 to 79, and 80 to 89 years was, respectively, 0.02, 0.3, 3.2, and 10.8.
Full summary, score breakdown and related studies → Original source
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1991-09-01
Neuropathological stageing of Alzheimer-related changes
58/100 ✓ Peer-reviewed Brain tissue and pathology Acta Neuropathologica
Key finding: The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. +2 more findings
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1991-09-01
Effect of education on the mini-mental state examination as a screening test for dementia
45/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: Subjects were 109 elderly outpatients with Alzheimer's dementia and 100 non-demented outpatient controls. +3 more findings
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1991-09-01
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein
48/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: This beta-amyloid protein is derived from a larger precursor molecule of which neurons are the principal producers in brain. +3 more findings
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1991-09-01
APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of human genetics
Key finding: We also tested for the APP codon 693 mutation associated with hereditary cerebral hemorrhage with amyloidosis-Dutch type, for PRIP gene missense mutations at codons 102, 117, and 200, and for the PRIP insertion mutations which are associated with Creutzfeld-Jakob disease and Gerstmann-Straussler Scheinker syndrome.
Full summary, score breakdown and related studies → Original source
August 1991 4
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1991-08-01
Reliability and validity of the Apathy Evaluation Scale
45/100 ✓ Peer-reviewed Risk factors Psychiatry research
Key finding: Operationally, the AES treats apathy as a psychological dimension defined by simultaneous deficits in the overt behavioral, cognitive, and emotional concomitants of goal-directed behavior. +4 more findings
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1991-08-01
Performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening test for dementia
48/100 ✓ Peer-reviewed Cognitive tests and assessment Psychological medicine
Key finding: Dementia diagnoses were made by both a clinician and a research interview using a computer algorithm to meet DSM-III-R and ICD-10 (Draft) criteria. +2 more findings
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1991-08-01
Accuracy of clinical diagnosis in parkinsonism--a prospective study
42/100 ✓ Peer-reviewed Lewy body dementia The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Key finding: After a mean duration of 12 years the final diagnosis was IPD in 41 cases which was confirmed in 31 (76%). +4 more findings
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1991-08-01
Abnormal brain spectrin immunoreactivity in sprouting neurons in Alzheimer disease
35/100 ✓ Peer-reviewed Biomarkers Neuroscience letters
Key finding: The present study showed that in Alzheimer disease (AD) neuropil, brain spectrin immunoreactivity is co-localized with synaptophysin in the presynaptic boutons. +2 more findings
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July 1991 11
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1991-07-12
Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition
41/100 ✓ Peer-reviewed Vascular contributions Science
Key finding: The hydrophobic carboxyl-terminal segment, beta(29-42), exists exclusively as an oligomeric beta sheet in solution, regardless of differences in solvent, pH, or temperature, suggesting that this segment directs the folding of the complete beta (1-42) peptide to produce the beta-pleated sheet found in amyloid plaques.
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1991-07-01
A Two-factor Model of Caregiving Appraisal and Psychological Well-Being
45/100 ✓ Peer-reviewed Risk factors Journal of Gerontology
Key finding: For spouses, caregiving satisfaction was not related to aspects of the stressor, but was a significant determinant of positive affect.
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1991-07-01
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
43/100 ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of aging
Key finding: Because even the very mildly demented brains showed substantial pathological change, emphasis was placed on examining the nondemented cases for the earliest changes that could be associated with Alzheimer's disease. +1 more finding
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1991-07-01
Substituted judgment: how accurate are proxy predictions?
40/100 ✓ Peer-reviewed Getting a diagnosis Annals of internal medicine
Key finding: In this study, surrogate decision makers' views (those of primary care providers and close family members) were compared with the decisions of currently competent chronically ill elderly patients, using a hypothetic cardiopulmonary resuscitation scenario under circumstances of current health and progressive dementia. +1 more finding
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1991-07-01
Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
36/100 ✓ Peer-reviewed Tau biomarkers FEBS letters
Key finding: Recent studies indicated that the formation of a major constituent of Alzheimer's disease (AD) senile plaques, called beta A4-peptide, does not result from normal processing of its precursor, amyloid precursor protein (APP). +2 more findings
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1991-07-01
Determinants of disease and disability in the elderly: The Rotterdam elderly study
46/100 ✓ Peer-reviewed Long-term cohort studies European Journal of Epidemiology
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1991-07-01
HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease
44/100 ✓ Peer-reviewed Inflammation and the immune system FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Key finding: Dementia and severe sensory and motor dysfunction characterize more severe disease. +3 more findings
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1991-07-01
Spousal caregivers of dementia victims: longitudinal changes in immunity and health
52/100 ✓ Peer-reviewed How common it is Psychosomatic medicine
Key finding: Caregivers also reported significantly more days of infectious illness, primarily upper respiratory tract infections. +1 more finding
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1991-07-01
Neurologic aspects of cobalamin deficiency
55/100 ✓ Peer-reviewed Getting a diagnosis Medicine
Key finding: In addition, the hematocrit correlated significantly with severity, independent of the longer duration of symptoms in nonanemic patients.
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1991-07-01
Mild cognitive impairment in the elderly: predictors of dementia
52/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: The mildly impaired subjects performed significantly more poorly than the controls on tests of recent memory, remote memory, language function, concept formation, and visuospatial praxis. +2 more findings
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1991-07-01
The short form of the Geriatric Depression Scale: a comparison with the 30-item form
42/100 ✓ Peer-reviewed Getting a diagnosis Journal of geriatric psychiatry and neurology
Key finding: The findings suggest that the short version of the GDS, like its longer predecessor, is an effective screening tool in the cognitively intact.
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June 1991 5
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1991-06-01
Risk factors associated with falls and injuries among elderly institutionalized persons
50/100 ✓ Peer-reviewed Clinical safety American journal of epidemiology
Key finding: A case-control study among 184 matched pairs of patients 65 years of age and older was undertaken to identify risk factors associated with falls and injuries in a long-term care facility in Baltimore, Maryland, in 1984-1985. +2 more findings
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1991-06-01
Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence
42/100 ✓ Peer-reviewed Brain tissue and pathology Trends in neurosciences
Key finding: As is often the case in science, the early enthusiasm for the cholinergic hypothesis has been tempered by the results of subsequent research. +3 more findings
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1991-06-01
Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage
45/100 ✓ Peer-reviewed Brain tissue and pathology American journal of human genetics
Key finding: George Hyslop et al. reported linkage of familial AD (FAD) in four early-onset families (mean age at onset [M] less than 50 years). +3 more findings
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1991-06-01
Intramuscular desferrioxamine in patients with Alzheimer's disease
70/100 ✓ Peer-reviewed Digital health tools Lancet (London, England)
Key finding: Although epidemiological and biochemical evidence suggests that aluminium may be associated with Alzheimer's disease (AD), there is no convincing proof of a causal link for aluminium in disease progression. +3 more findings
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1991-06-01
Estimated prevalence of dementia among elderly black and white community residents
48/100 ✓ Peer-reviewed Disparities Archives of neurology
Key finding: A stratified random sample of 83 black and 81 white community residents aged 65 years and older in a five-county area in the Piedmont region of North Carolina was evaluated for dementia, using the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, and the National Institute of Neurological Disorders and Stroke--Alzheimer's Disease and Related Disorders Association criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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