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Home › Research › Topics › prospective

prospective

1,139 studies tagged prospective, dated 1978-04-01 to 2026-09-26. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Public awareness of the hearing loss-dementia link and self-reported behavioral changes in middle- to older-aged Canadians 2026-09-26
  2. Patterns of modifiable lifestyle, behavioural and health-related risk factors and their associations with incident dementia in UK Biobank 2026-09-25
  3. Excess hypoglycaemia-related hospitalisation in older adults with comorbid type 2 diabetes and dementia: a UK Biobank cohort study 2026-09-16

Studies

1,139 studies carry this tag.

Date range

1978 to 2026

Top journals

  • Neurology 134
  • Alzheimer s & Dementia 52
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 33
  • Journal of the American Geriatrics Society 32
  • JAMA neurology 27

362 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Risk of stroke associated with risperidone in dementia with and without comorbid cardiovascular disease: population-based matched cohort study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The British Journal of Psychiatry 2025-10-09 Vascular contributions

    In the overall cohort (28 403 risperidone users and 136 324 mtatched controls), risperidone was associated with increased risk of stroke (adjusted hazard ratio: 1.28; 95% CI: 1.20-1.37).

  2. Varicella-zoster virus reactivation and the risk of dementia

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Nature Medicine 2025-10-06 Prevention and risk

    Varicella-zoster virus (VZV) is a neurotropic virus that establishes lifelong latency in humans.

  3. Cardiovascular risk factors and the allostatic interoceptive network in dementia

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Cardiovascular Research 2025-10-01 Risk factors

    We recruited 1501 participants (304 with FTLD, 512 with AD, and 685 healthy controls) from the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat).

  4. COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. npj Dementia 2025-10-01 Lewy body dementia

    We observed adults aged 50 years and older from the UK Biobank over a median observational period exceeding two years following COVID-19 infection.

  5. Polypharmacy and risk of dementia progression in older adults with mild cognitive impairment: A longitudinal cohort study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer s & Dementia Translational Research & Clinical Interventions 2025-10-01 Mild cognitive impairment

    = 0.005). Cox regression analysis revealed that polypharmacy was significantly associated with a reduced risk of MCI progression to dementia (hazard ratio [HR] = 0.49, 95% confidence interval [CI]: 0.31 to 0.78) after adjusting for covariates.

  6. Risk Factors for Dementia in a Sample of Patients From a Quaternary Care Hospital Network in the United Arab Emirates

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Alzheimer Disease & Associated Disorders 2025-10-01 Risk factors

    A total of 281 dementia patients (mean age 74.9 ± 9.2 y, 46.3% females) and 281 age-matched controls (mean age 74.3 ± 4.6 y, 55.9% females) were included.

  7. Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Alzheimer s Research & Therapy 2025-09-30 Long-term cohort studies

    During a median follow-up of 13.8 years, 3,035 incident dementia cases were recorded, including 1,304 Alzheimer's disease (AD) cases and 597 vascular dementia (VD) cases.

  8. Cardiovascular Risk Trajectories and Risk of Developing Stroke and Dementia

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurology 2025-09-30 Vascular contributions

    Among 2,335 participants (mean age 52.3 ± 11.2 years; 56.6% women), CVD risk trajectories over 10 years were classified as accelerated increase (29.2%), moderate increase (30.9%), or stable (39.9%).

  9. Associations of alcohol drinking with incident dementia: a prospective study from the UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. European Journal of Epidemiology 2025-09-27 Prevention and risk

    Relationship between alcohol drinking and incident dementia remained uncertain.

  10. Association between the Frequency of Individual Outdoor Activity and Risk of Incident Dementia in an Elderly Population in China: A National Cohort Study

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neuroepidemiology 2025-09-25 Cognitive tests and assessment

    Over a median follow-up period of 4.33 years, 637 participants (7.27%) developed dementia.

  11. Risk factor analysis of cognitive frailty in older adults with type 2 diabetes mellitus: a cross-sectional study

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Frontiers in Aging Neuroscience 2025-09-25 Risk factors

    The prevalence of CF was 24.3%. Cerebrovascular disease (OR: 2.39, 95% CI: 1.44-3.97) and peripheral arterial disease (OR: 1.74, 95% CI: 1.03-2.95) were significant risk factors, while higher education (OR 0.85, 95% CI 0.76-0.94) and later diabetes onset (OR: 0.93, 95% CI: 0.88-0.98) were protective.

  12. Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Frontiers in Neurology 2025-09-24 Cognitive tests and assessment

    Gait abnormalities are associated with cognitive decline, and reduced gait speed and gait asymmetry are markers of cognitive decline and increased fall risk in patients with established DLB.

  13. Dementia Risk in People With Type 1 Diabetes and Associated Risk Factors: A Nationwide, Register-Based Cohort Study

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Diabetes Care 2025-09-19 Risk factors

    After a median follow-up time of 14.3 (7.9-20.0) years, dementia was recorded in 530 (1.2%) individuals with type 1 diabetes and 1,867 (0.9%) age-, sex-, and county-matched control individuals (mean baseline age 33.0 [14.0] years).

  14. Hypertension, Diabetes and Depression as Modifiable Risk Factors for Dementia: A Common Data Model Approach in a Population-Based Cohort, with Study Protocol and Preliminary Results

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Clinical Medicine 2025-09-19 Risk factors

    The final cohort comprised more than 3 million individuals, with a mean baseline age of 63–65 years and a female proportion of 52–55%.

  15. Bidirectional impact of dementia and aspiration pneumonia on cognitive decline in older adults: A retrospective cohort analysis

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Geriatrics and gerontology international/Geriatrics & gerontology international 2025-09-18 Cognitive tests and assessment

    Among 500 dementia patients (mean age 78.3 ± 7.2 years), Kaplan-Meier analysis revealed significantly earlier pneumonia onset in severe dementia patients (log-rank P < 0.001), with Cox regression showing that severe dementia conferred triple the pneumonia risk (hazard ratio [HR] = 3.01, 95% confidence interval [CI]: 2.15-4.21) and that swallowing dysfunction independently increased the hazard ratio 3.45-fold (95% CI: 2.61-4.55); aspiration pneumonia accelerated cognitive decline (β = -2.35, 95% CI: -3.12 to -1.58).

  16. The role of sleep in dementia prevention: building the case for causality

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. SLEEP 2025-09-18 Risk factors

    Kening Jiang, Daniel D Callow, Adam P Spira; The Role of Sleep in Dementia Prevention: Building the Case for Causality, Sleep, , zsaf285, https://doi.org/1

  17. Associations between falls and other serious adverse events and antihypertensive medication in individuals with dementia: An observational cohort study

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. PLoS Medicine 2025-09-17 Clinical safety

    This was a retrospective analysis using nationally representative UK general practice population between 1998 and 2018, from electronic health records (Clinical Practice Research Datalink, CPRD, GOLD).

  18. Outdoor physical activity, residential green spaces and the risk of dementia in the UK Biobank cohort

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Communications Medicine 2025-09-17 Long-term cohort studies

    Outdoor activity is linked to lower dementia risk, particularly in those living in more accessible GS.

  19. The Association between Glaucoma and Dementia in a National Cohort of All of Us Participants

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Ophthalmology 2025-09-16 How common it is

    Among the 393 497 All of Us participants with linked EHRs, we identified 9444 individuals (2.40%) with glaucoma diagnoses (excluding participants with diagnoses of dementia before glaucoma) and 37 776 matched controls without glaucoma.

  20. Childhood Loneliness and Cognitive Decline and Dementia Risk in Middle-Aged and Older Adults

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. JAMA Network Open 2025-09-12 Brain tissue and pathology

    Among 13 592 participants (mean [SD] age, 58.34 [9.39] years; 7175 [52.8%] female), 6525 (48.0%) experienced possible childhood loneliness, and 565 (4.2%) reported childhood loneliness.

  21. Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Arteriosclerosis Thrombosis and Vascular Biology 2025-09-11 Genetics

    Overall, 430 093 participants were included.

  22. Association Between Dietary Biotin Intake and Dementia Risk, Including Alzheimer's Disease: A Prospective Study of 122 959 UK Biobank Participants

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular Nutrition & Food Research 2025-09-07 Long-term cohort studies

    The relationship between dietary biotin intake and cognitive function remains unclear.

  23. Midlife Vascular Risk Factors, Parkinson Disease, and Parkinson Disease-Dementia

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Neurology 2025-09-04 Disparities

    Among 13,875 individuals with nonmissing VRF and outcome data with up to 30 years of follow-up (25% Black, 54% female), 179 developed PD at a mean age of 73.4 years, 94 developed PDD at a mean age of 79.2 years, and 1,791 developed dementia without PD at a mean age of 79.7 years.

  24. Effect of depression on risks of Alzheimer’s disease and vascular dementia: A real-world longitudinal study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Psychiatry Research 2025-09-02 Lewy body dementia

    During an average follow-up of 3.63 years, we observed a total of 1 493 individuals developing dementia among 4 341 depressed and 43 214 matched non-depressed individuals (62.4% female; mean [SD] age at baseline 64.4 [11.1] years).

  25. Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2025-09-01 Risk factors

    Phenoconverters had higher FW in the NBM and posterior SN.

  26. Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer s & Dementia 2025-09-01 Mild cognitive impairment

    During a 7-year median follow-up, type 2 diabetes was associated with the highest risk of all-cause dementia (hazard ratio [HR] 1.18, 95% confidence interval [CI]: 1.06 to 1.31), followed by hypertension and hyperlipidemia.

  27. Stroke–heart syndrome and risk of incident dementia among patients with first‐ever ischemic stroke: A territory‐wide population‐based cohort study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer s & Dementia 2025-09-01 Vascular contributions

    Of the 130,605 included patients with ischemic stroke, 12,696 (9.7%) patients developed SHS.

  28. Constipation preceding stroke, dementia and Parkinson’s disease in middle-aged and older adults: a population-based cohort study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Age and Ageing 2025-08-29 Vascular contributions

    Out of 462,327 eligible participants, those with constipation were associated with higher incidence of three outcome diseases (1415/20,263 [7.0%]) than those without (18,848/442,064 [4.3%]), with adjusted hazard ratio (HR) being 1.35 [1.27-1.42].

  29. Global trends in Alzheimer’s disease and other dementias in adults aged 55 and above (1992–2021): An age-period-cohort analysis based on the GBD 2021

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. PLoS ONE 2025-08-29 How common it is

    From 1992 to 2021, ADOD incidence among individuals aged ≥55 increased by 143.88%.

  30. Incidence of dementia among individuals 70 years and older in Norway: A HUNT study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of Alzheimer s Disease 2025-08-29 How common it is

    BackgroundWith increasing population longevity, Alzheimer's disease and dementia have become a health priority, and high-quality incidence estimates are needed.

  31. Age-related hearing loss and dementia risk across the lifespan: mechanisms, equity, and prevention

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience 2025-08-28 Prevention and risk

    Age-related hearing loss (ARHL) has emerged as a significant and potentially modifiable risk factor for neurodegenerative disorders, including Alzheimer's disease.

  32. Associations between traumatic brain injury and the prevalence of Alzheimer’s disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of Prevention of Alzheimer s Disease 2025-08-28 How common it is

    We assessed 452,718 patients (mean age: 67.16 years).

  33. Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of Stroke and Cerebrovascular Diseases 2025-08-27 Vascular contributions

    The relative risk of dementia following cerebral hemorrhage ( relative risk(RR):3.02[1.17-7.78],P<0.001 ) was higher than that of cerebral infarction (RR: 2.07[1.47-2.96], P<0.001).

  34. Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature Medicine 2025-08-25 Prevention and risk

    Here we show that the associations of 57 metabolites with dementia risk varied by APOE4 genotype or other AD/ADRD risk variants.

  35. Race and Ethnicity and Comorbidities Among Medicare Beneficiaries With Young-Onset Dementia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. JAMA Network Open 2025-08-20 Disparities

    In 2022, among a total of 2 189 231 Medicare beneficiaries aged 45 to 64 years, 71 092 (3.25%) received a diagnosis of YOD.

  36. Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. The Lancet Regional Health - Europe 2025-08-20 How common it is

    Of 736 patients (245 [33%] female, mean age 68·0 years [SD 11·2], median admission National Institutes of Health Stroke Scale (NIHSS) 3 [IQR 1-5]), 557 (76%) were followed up until death or the end of the study, and 706 (96%) contributed to the PSD analysis.

  37. Exploring the effect of pre-clinical Alzheimer’s disease on blood pressure using Mendelian randomisation and parental dementia as an instrumental variable in UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. BMC Medicine 2025-08-19 Long-term cohort studies

    Both the higher parental dementia instrument and participant genetic instrument score were associated with higher mean SBP (difference in mean SBP mmHg per 1SD higher score: 0.12, 95% CI 0.06 to 0.17, p < 0.0001, and 0.07, 95% CI 0.00 to 0.13, p=0.037, respectively) but not DBP.

  38. Proteomic signature of dementia risk in type 2 diabetes

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of Advanced Research 2025-08-18 Digital health tools

    We identified 471 proteins with significant interaction effects between T2D and dementia risk.

  39. Self-Reported Hearing Aid Use and Risk of Incident Dementia

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. JAMA Neurology 2025-08-18 Prevention and risk

    This cohort study compares the risk of incident all-cause dementia among people with hearing loss who use vs do not use hearing aids.

  40. Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Communications Medicine 2025-08-14 Brain tissue and pathology

    We investigated whether a discrepancy between chronological and biological age in midlife and late-life is associated with cognition and dementia risk.

  41. Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of Sleep Research 2025-08-12 Vascular contributions

    Sleep, sedentary behaviour, and physical activity (PA) are important for brain health.

  42. Cardiovascular-kidney-metabolic health, genetic susceptibility, and the risk of dementia: A prospective cohort study

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The Journal of Prevention of Alzheimer s Disease 2025-08-10 How common it is

    Among 331,731 participants (mean ± SD age, 56.53 ± 8.1 years; 156,762 [47.26 %] male), 4413 (1.33 %) developed dementia during a mean follow-up of 12.8 years.

  43. Changes in sleep dimensions, cognitive transitions, and incident dementia: a two-cohort longitudinal study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. SLEEP 2025-08-09 Risk factors

    A total of 8994 and 14 720 participants were involved in the change-to-change analyses and change-to-dementia analyses, respectively.

  44. Racial disparities in the association of epigenetic age acceleration with the transition between normal cognition, mild cognitive impairment and dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Global Transitions 2025-08-07 Disparities

    Exposure to accelerated epigenetic aging was significantly associated with a higher risk of transition from NC to MCI as well as progression from MCI to dementia.

  45. Social isolation and loneliness as modifiable risk factors for dementia: Evidence-based interventions and public health implications

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Advanced Neurology 2025-08-07 Risk factors

    Social isolation and loneliness have emerged as significant and modifiable risk factors for dementia, especially in older adults.

  46. Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer’s disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Frontiers in Aging Neuroscience 2025-08-06 Mild cognitive impairment

    The data of 508,107 individuals were analyzed (mean [standard deviation] age, 67.6 [10.7] years; 66.8% women and 33.2% men), and 39,318 developed Alzheimer's disease (22,572 controls and 16,746 using aspirin).

  47. Health Awareness and Dementia Risk Among Older Adults with Hypertension and Diabetes: A Cross-sectional Study in Thailand

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Iranian Journal of Psychiatry and Behavioral Sciences 2025-08-06 Risk factors

    Participants exhibited strong awareness of the risks associated with complications and the severity of chronic diseases.

  48. Association of sugar intake with incident dementia in the UK Biobank: a prospective cohort study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of Prevention of Alzheimer s Disease 2025-08-05 Long-term cohort studies

    Higher intakes of total sugar (HR = 1.292, 95 % CI = 1.148--1.453) and free sugar intake (HR = 1.254, 95 % CI = 1.117--1.408) were significantly associated with increased dementia risk.

  49. Sex differences in clinical risk factors for Alzheimer's dementia patients with early-onset and late-onset

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Frontiers in Global Women s Health 2025-08-04 Getting a diagnosis

    A multivariate analysis was also performed to predict specific risk factors associated with male and female EOAD and LOAD patients.

  50. Age at First Childbirth and Dementia Risk: A Cross‐Sectional Ecological Analysis of Female Prevalence, Sex Disparities, and Public Health Implications

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Health Science Reports 2025-08-01 Disparities

    = 126). Subgroup analyses revealed stronger associations in LMICs than in high-income countries.

From across this tag

10 of the 1,130 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts