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46/100

✓ Peer-reviewed alzhub usefulness score 46 out of 100. Cognitive tests and assessment

Topic: Risk, prevention and care in population studies

Objective To investigate the association between gait parameters and cognitive decline in patients with dementia with Lewy bodies (DLB) and evaluate the impact of gait abnormalities on fall risk. Methods This cross-sectional study enrolled 63 DLB patients. Gait analysis, including gait speed, stride length, gait symmetry, and swing time, was performed using a pressure-sensing walkway. Cognitive function was assessed using the MoCA and MMSE. Spearman correlation analysis and multiple linear regression models were used to examine the relationship between gait parameters and cognitive function. Logistic regression models, adjusted for potential confounders, were employed to analyze the effect of gait abnormalities on fall risk. Results Gait speed showed significant positive correlations with MoCA score (p = 0.001) and stride length (p = 0.003), and a positive correlation with MMSE score (p = 0.005). Gait symmetry was weakly positively correlated with MMSE score (p = 0.027). Patients with MoCA scores below 20 exhibited a 22% reduction in gait speed (p = 0.002), shortened stride length (p = 0.001), decreased gait symmetry (p = 0.034), and prolonged swing time (p = 0.021) compared to those with higher scores. Logistic regression analysis revealed that for each 1 standard deviation decrease in gait speed, fall risk increased by 33% (p = 0.001). For each 1-cm decrease in stride length, fall risk increased by 21% (p = 0.025). For each 1-unit decrease in gait symmetry, fall risk increased by 28% (p = 0.007). Patients with a history of falls demonstrated more pronounced gait deterioration. Specifically, patients with more than 2 falls exhibited a 13% reduction in stride length (p = 0.011) and a 12% prolongation in swing time (p = 0.022). Conclusion Gait abnormalities are associated with cognitive decline, and reduced gait speed and gait asymmetry are markers of cognitive decline and increased fall risk in patients with established DLB.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zhou, S., Liu, M., Kuai, J., Yi, T., Zheng, Y., Wang, C., et al. (2025). Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies. Frontiers in Neurology. https://doi.org/10.3389/fneur.2025.1670016

Vancouver

Zhou S, Liu M, Kuai J, Yi T, Zheng Y, Wang C, et al. Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies. Frontiers in Neurology. 2025. doi:10.3389/fneur.2025.1670016. PMID: 41069430.

BibTeX

@article{zhou2025-41069430,
  author  = {Zhou, Su and Liu, Mengran and Kuai, Jun and Yi, Tingting and Zheng, Yuechang and Wang, Congcong and Peng, Junyu and Tian, Xiaojun},
  title   = {{Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1670016},
  pmid    = {41069430},
  url     = {https://doi.org/10.3389/fneur.2025.1670016}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Results Gait speed showed significant positive correlations with MoCA score (p = 0.001) and stride length (p = 0.003), and a positive correlation with MMSE score (p = 0.005).
Patients with MoCA scores below 20 exhibited a 22% reduction in gait speed (p = 0.002), shortened stride length (p = 0.001), decreased gait symmetry (p = 0.034), and prolonged swing time (p = 0.021) compared to those with higher scores.
Logistic regression analysis revealed that for each 1 standard deviation decrease in gait speed, fall risk increased by 33% (p = 0.001).
Patients with a history of falls demonstrated more pronounced gait deterioration.
Conclusion Gait abnormalities are associated with cognitive decline, and reduced gait speed and gait asymmetry are markers of cognitive decline and increased fall risk in patients with established DLB.

Why it matters

In 63 patients with dementia with Lewy bodies, slower gait speed and shorter stride length were associated with lower cognitive scores and higher fall risk, with each 1 standard deviation decrease in gait speed raising fall risk by 33%. This is a cross-sectional study of gait and falls, not a test of treatment, cure, or prevention.

Study details

Study designcross-sectional
Participants63
Effect sizeincreased by 33%; increased by 21%; increased by 28%
Evidence strengthLow

How this study scored 46/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 44 of the 96 points we could judge it on, which is 46 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in Neurology)
Journal's citation record	2 / 4	Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	63 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 4.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	1 / 3	University of Bristol: institution h-index 1,260 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41069430)
Free to read	2 / 2	Free to read
Points	44 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 44 of the 96 points we could judge it on is 46 out of 100.
Total	46 / 100	—

What each of these 20 components measures, and what this score is not →

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