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Actigraphy-estimated sleep and 24-hour activity rhythms and the risk of dementia
Lysen TS, Luik AI, Ikram MK, Tiemeier H, Ikram MA.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020-06-19
Topic: Risk, prevention and care in population studies
Introduction We investigated and compared associations of objective estimates of sleep and 24-hour activity rhythms using actigraphy with risk of dementia. Methods We included 1322 non-demented participants from the prospective, population-based Rotterdam Study cohort with valid actigraphy data (mean age 66 ± 8 years, 53% women), and followed them for up to 11.2 years to determine incident dementia. Results During follow-up, 60 individuals developed dementia, of which 49 had Alzheimer's disease (AD).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lysen, T. S., Luik, A. I., Ikram, M. K., Tiemeier, H., & Ikram, M. A. (2020). Actigraphy-estimated sleep and 24-hour activity rhythms and the risk of dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12122
Vancouver
Lysen TS, Luik AI, Ikram MK, Tiemeier H, Ikram MA. Actigraphy-estimated sleep and 24-hour activity rhythms and the risk of dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020. doi:10.1002/alz.12122. PMID: 32558256.
BibTeX
@article{lysen2020-32558256,
author = {Lysen, T. S. and Luik, A. I. and Ikram, M. K. and Tiemeier, H. and Ikram, M. A.},
title = {{Actigraphy-estimated sleep and 24-hour activity rhythms and the risk of dementia}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2020},
doi = {10.1002/alz.12122},
pmid = {32558256},
url = {https://doi.org/10.1002/alz.12122}
}
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Key findings
- Methods We included 1322 non-demented participants from the prospective, population-based Rotterdam Study cohort with valid actigraphy data (mean age 66 ± 8 years, 53% women), and followed them for up to 11.2 years to determine incident dementia.
- Results During follow-up, 60 individuals developed dementia, of which 49 had Alzheimer's disease (AD).
- Poor sleep as indicated by longer sleep latency, wake after sleep onset, and time in bed and lower sleep efficiency, as well as an earlier "lights out" time, were associated with increased risk of dementia, especially AD.
- We found no associations of 24-hour activity rhythms with dementia risk.
Why it matters
In 1,322 older adults from the Rotterdam Study who wore an activity monitor, taking longer to fall asleep, more time awake at night, more time in bed, less efficient sleep and an earlier "lights out" time were associated with a higher risk of dementia, especially Alzheimer's disease, over up to 11.2 years. Daily activity rhythms showed no link with dementia risk. Only 60 people developed dementia, and this observational study does not show that changing sleep habits prevents it.
Study details
- Participants1,322
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,322 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 85 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.6 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 7.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 3 / 4 | Cited 50 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32558256) |
| Free to read | 2 / 2 | Free to read |
| Total | 59 / 100 | — |
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