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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Vascular contributions

Topic: Risk, prevention and care in population studies

Out of 462,327 eligible participants, those with constipation were associated with higher incidence of three outcome diseases (1415/20,263 [7.0%]) than those without (18,848/442,064 [4.3%]), with adjusted hazard ratio (HR) being 1.35 [1.27-1.42]. Specifically, those with constipation had a 20%, 50% and 56% higher risk of stroke, dementia and PD, respectively. Both self-reported and diagnosed constipation were associated with a higher risk of these conditions, with HR being 1.31 (1.23-1.40) and 1.44 (1.30-1.59), respectively. Interestingly, the association between constipation and neurological disorders was stronger within the first 2 years from baseline. These findings support the biological link between constipation and neurological disorders. Given its potential role as a prodromal symptom for these diseases, both diagnosed and self-reported constipation should be considered in risk prediction models.

Key findings

Out of 462,327 eligible participants, those with constipation were associated with higher incidence of three outcome diseases (1415/20,263 [7.0%]) than those without (18,848/442,064 [4.3%]), with adjusted hazard ratio (HR) being 1.35 [1.27-1.42].
Specifically, those with constipation had a 20%, 50% and 56% higher risk of stroke, dementia and PD, respectively.
Both self-reported and diagnosed constipation were associated with a higher risk of these conditions, with HR being 1.31 (1.23-1.40) and 1.44 (1.30-1.59), respectively.
Interestingly, the association between constipation and neurological disorders was stronger within the first 2 years from baseline.
These findings support the biological link between constipation and neurological disorders.

Why it matters

People with constipation had a higher risk of later stroke, dementia and Parkinson's disease, with the dementia risk 50% higher, and the link was stronger in the first two years. The authors suggest constipation may be a prodromal symptom and should be considered in risk prediction models.

Study details

Study designcohort study
Effect size7.0%; 4.3%
Evidence strengthModerate

How this study scored 52/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Age and Ageing)
Journal's citation record	2 / 4	Age and Ageing: journal h-index 231 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.3 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Jin-Ling Tang: h-index 30 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Cambridge: institution h-index 1,973 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 12 institution(s) in 5 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40975837)
Free to read	2 / 2	Free to read
Total	52 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Yun, Q., Wang, S., Li, B., Yang, Z., Wei, C., Yuan, J., et al. (2025). Constipation preceding stroke, dementia and Parkinson’s disease in middle-aged and older adults: a population-based cohort study. Age and Ageing. https://doi.org/10.1093/ageing/afaf257

Vancouver

Yun Q, Wang S, Li B, Yang Z, Wei C, Yuan J, et al. Constipation preceding stroke, dementia and Parkinson’s disease in middle-aged and older adults: a population-based cohort study. Age and Ageing. 2025. doi:10.1093/ageing/afaf257. PMID: 40975837.

BibTeX

@article{yun2025-40975837,
  author  = {Yun, Qingping and Wang, Shiyu and Li, Bingyu and Yang, Zhirong and Wei, Chang and Yuan, Jinqiu and Hu, Jun and Li, Ye and others},
  title   = {{Constipation preceding stroke, dementia and Parkinson’s disease in middle-aged and older adults: a population-based cohort study}},
  journal = {Age and Ageing},
  year    = {2025},
  doi     = {10.1093/ageing/afaf257},
  pmid    = {40975837},
  url     = {https://doi.org/10.1093/ageing/afaf257}
}

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