Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Most motor signs occur frequently and progress rapidly in Alzheimer disease.
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aECAD was associated with significantly worse scores in processing speed (β = -0.19, p = 0.004) and executive function (β = -0.20, p = 0.009) domains after controlling for age, sex, education, race, and ethnicity.
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Significant interaction effects were observed: MoCA (β = -1.86×10-4, P = 0.006) and PACC (β = -4.0×10-5, P = 0.004), indicating HDL moderates the negative association between NfL and cognition.
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With aging, the hippocampal formation shows variable structural atrophy, which is associated with a decline in cognitive performance.
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55/100
A total of 260 AD deaths occurred during a median follow-up of 9.8 years.
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Digital cognitive testing using online platforms has emerged as a potentially transformative tool in clinical neuroscience.
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55/100
The Alzheimer's Disease Neuroimaging Initiative (ADNI) Administrative Core oversees and coordinates all ADNI activities, to ensure the success and maximize the impact of ADNI in advancing Alzheimer's disease (AD) research and clinical trials.
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Higher concentrations of pTau181 and GFAP were associated with slower responses on working memory tasks (pTau181: β = 0.261; p = 0.007; GFAP: β = 0.175, p = 0.036), and higher β-amyloid 42/40 ratio was associated with better vocabulary (β = 0.260, p = 0.009).
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Average compliance by time of day ranged from 90.2% for morning sessions, to 77.9% for afternoon sessions, and 84.4% for evening sessions.
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The best predictor of CDR at 36 months was M, a DCB reflecting recall ability (area under the curve = 0.84), outperforming traditional scores.
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55/100
We evaluate-also in a critical way-the methods commonly used to define and measure CR, including sociobehavioral proxies, neuroimaging, and electrophysiological and genetic measures.
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55/100
Our results demonstrated that dual-task could significantly improve the ability to predict cognitive impairment based on gait parameters such as gait speed (GS) and stride length (SL).
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Age- and sex-specific reference values were generated for three DANA tasks.
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The fractal dimension (FD) and global vein width were significantly correlated with the CI (P < 0.05).
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The aMCI plasma Aβ+ group evidenced the greatest percentage of SIEs, followed by the aMCI Aβ-.
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VRFs and gait were associated with diffusion changes even in low age strata.
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Cross-sectionally, participants with ≥3 SI had twice the prevalence of ECI (prevalence ratio = 2.10, p = 0.02).
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These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research.
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55/100
The distribution of subjects between ES and ERS among the groups differed considerably, as grouping allocated 32 subjects to ES group 2, but only 2 to ERS group 2.
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Higher ISI score was associated with greater average levels of CSF Aβ42 (per point: 30.7 pg/mL, 95% CI: 4.17-57.3, p = 0.023), as was higher WASO (per 10 min: 136 pg/mL, 95% CI: 48-223, p = 0.002) and more awakenings (per 5:123 pg/mL, 95% CI = 55-192, p < 0.001).
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Higher cognitive (HR: 0.91/SD, 95%CI: 0.84; 1.00) and brain reserve (HR: 0.88/SD, 95%CI: 0.77; 1.00) were associated with a lower risk of a depressive event after adjustment for baseline depressive symptoms.
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Numerous studies have shown abnormal brain functional connectivity in individuals with Alzheimer's disease (AD) or amnestic mild cognitive impairment (aMCI).
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long baseline nighttime and 24-h sleep durations (≥9 h) as well as being persistent or becoming long sleepers during follow-up were associated with dementia incidence.
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Of the 17,668 respondents, 8,396 (47.5%) were men.
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Subjective cognitive decline (SCD), as expressed by older adults, is associated with negative affect, which, in turn, is a likely risk factor for Alzheimer's Disease (AD).
From across this topic
9 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?
- Brain pathology and cognitive scores prior to onset of late-life depression
- Circadian Rhythm Sleep-Wake Disorders
- Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy
- Retinal image analytics detects white matter hyperintensities in healthy adults
- Treatment of obstructive sleep apnea may contribute to long-term stabilisation of memory in Alzheimer's and vascular dementia
- Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau
- Crossed cerebellar diaschisis in Alzheimer's disease
- Memory and MRI-based hippocampal volumes in aging and AD