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Home › Research › Topic

Brain imaging, connectivity and assessment

1,533 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. In-clinic validation of a smartphone-based finger tapping test for use in neurodegenerative and neurological populations

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-07-07 Cognitive tests and assessment

    These findings support mApp-FTT validity as a measure of motor function across neurodegenerative conditions.

  2. Nonlinear Association of Length of Stay With In-Hospital Mortality in Alzheimer’s Disease Hospitalizations: Admission-Only vs Inpatient-Course Prediction Using Explainable Machine Learning

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-07-07 Clinical safety

    Among 11,377 AD hospitalizations, 600 in-hospital deaths occurred (5.27%).

  3. Determinants of fractal motor activity regulation: insights from a large community-dwelling multi-ethnic population

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-07-06 Disparities

    We found opposite effects of age on FMAR at both short and long time scales, respectively (ßAge=0.014, 95% C.I. [0.009,0.019] and ßAge=-0.015, 95% C.I. [-0.026,-0.005]), as well as differences between women and men at long time scales (ßSexMen=+0.028, 95% C.I. [0.012,0.044]).

  4. Traumatic Brain Injury Increases Risk of Psychiatric Disorders Following Neurological Disease: Evidence from the UK Biobank Cohort

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-07-06 Disparities

    Lifetime TBI exposure is associated with increased likelihood and long-term risk of psychiatric disorders in individuals with dementia, stroke, and Parkinson’s disease, with mood disorders being the most consistent outcome across conditions.

  5. Effects of high-intensity interval training with or without resistance training on Alzheimer’s disease brain signatures in individuals with coronary artery disease: the Heart-Brain randomized controlled trial

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-07-04 Clinical trials

    A 12-week HIIT+RT intervention was more effective than HIIT alone in increasing the thickness/volume signature in individuals with CAD, yet no differences were observed compared to UC and the interventions did not affect the GMMD signature.

  6. Dissociable structural and molecular pathways of age-related variability in sustained attention

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-07-03 Biomarkers

    Older age was associated with lower Att-Z (β = −0.315, p < 0.001).

  7. Can modifiable dementia risk factors help account for the predictive link between personality and midlife cognitive health? Evidence from a 17-year longitudinal study of Mexican-origin adults

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. PsyArXiv 2026-07-01 Risk factors

    All Big Five domains had prospective associations with multiple dementia risk factors and with cognitive impairment, cognitive function, and self-reported memory.

  8. Digitized and AI-Assisted Scoring of Cognitive Assessments in ALS and Neurodegenerative Diseases: A Scoping Review of Consistency, Reliability, and Cross-Site Applicability

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. PsyArXiv 2026-06-25 Cognitive tests and assessment

    The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) is the most validated and widely-used ALS-specific cognitive assessment tool, yet paper-and-pencil manual scoring introduces inter-rater variability that can significantly limit reliability and reproducibility in multi-site clinical trials.

  9. Prevalence of epilepsy and young-onset dementia in adults with intellectual disability: Contrasting Down syndrome and autism diagnoses

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. PsyArXiv 2026-06-15 Costs and economics

    Higher prevalence was observed in the ID group relative to the general population for epilepsy, young-onset ADRD, and their comorbidity.

  10. Crossmodal plasticity effects of hearing loss and ageing in the human auditory cortex

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-06-10 Risk factors

    Crossmodal plasticity refers to the phenomenon by which typical sensory areas respond to stimulation in other sensory modalities when their main input is absent or reduced.

  11. Functional-vs-Cognitive Decline Heterogeneity in Alzheimer’s Disease: LLM-Curation of Decades of Clinical Notes and GLP1RA Trial Design

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-06-09 Drug development

    EVOKE and EVOKE+ trials showed no population-level slowing of early symptomatic Alzheimer’s disease (AD) with semaglutide, motivating an assessment of whether clinical-note phenotyping over decades of routine care could identify distinct AD trajectories.

  12. Mapping U.S. POINTER Cognitive-Slope Gains Onto Predicted Clinical Progression: An External-Cohort Translation Analysis With Exploratory Economic Thresholds

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-05-20 Costs and economics

    POINTER reported a modest structured-versus-self-guided difference in the annual rate of global cognitive change.

  13. A multidomain intrinsic capacity score tracks longitudinal health trajectories in the UK Biobank

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-04-13 Risk factors

    Quantitative measures for tracking functional health have generally been lacking.

  14. Systematic Review of Population-Based Studies of Prevalence and Incidence of Aging-Associated Neurodegenerative Diseases in Russia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-04-06 Digital health tools

    The prevalence of dementia and Parkinson’s disease in Russia varies widely depending on diagnostic method, age group, and study design.

  15. Physiological, Histological, and Cognitive Characterization of a Rhesus Macaque Model of Presbycusis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-03-27 Risk factors

    Age-related hearing loss (ARHL), or presbycusis, is one of the most prevalent sensory deficits in older adults and has been increasingly implicated in cognitive decline and dementia.

  16. Hearing Loss as a Modifiable Risk Factor for Dementia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-03-18 Risk factors

    This study evaluated hearing loss (HL) as a potential early indicator of dementia.

  17. Multi-site MRI analysis of morphometric differences in brain regions in the presence of hearing loss and tinnitus across the adult lifespan

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-03-10 Risk factors

    The impact of age and hearing loss on the brain has garnered significant attention, as both factors have been implicated in the development of cognitive impairment or dementia.

  18. Nocturnal Physiological Associations with Agitation Occurrence and Severity in Dementia: An Explanatory Study Using Contactless Sleep Sensing

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-03-02 Health systems and care delivery

    Passive sleep monitoring identified physiologically interpretable sleep markers associated with next-day agitation occurrence, supporting prospective evaluation of under-mattress sensing as a source of short-term risk information for dementia care.

  19. Multimodal latent composites are associated with cognition and Alzheimer’s disease dementia: a framework for systems-level brain health

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-02-23 Biomarkers

    Compared to the CN group, both MCI (β=−1.25, SE=0.19, p <.001) and AD dementia (β=−1.52, SE=0.16, p <.001) participants had lower Brain & Vascular Health composite scores.

  20. Performance at digital testing in Alzheimer’s Disease is predicted by selective disruption of microstructural integrity

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-02-12 Cognitive tests and assessment

    White matter microstructural abnormalities are increasingly found to be associated with cognitive impairment in Alzheimer’s Disease (AD).

  21. A retrieval-augmented generation large language model framework for accurate dementia identification from electronic health records

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-25 Digital health tools

    A RAG-based LLM pipeline without structured ICD codes improved dementia ascertainment from EHR data compared with ICD-based rules and keyword-based filtering.

  22. Cross-sectional and longitudinal associations between sleep disturbances and psycho-affective symptoms in older adults: influence of amyloid positivity

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-21 Digital health tools

    In cognitively unimpaired older adults, associations between sleep disturbances and psycho-affective symptoms differ according to Aβ status.

  23. Detecting Preclinical Alzheimer’s Disease Risk in Cognitively Normal Adults Using Speech Acoustics: Validation with Plasma p-Tau217 and APOE-ε4 Status

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-16 Digital health tools

    Spontaneous speech acoustics capture p-tau217/APOE-defined AD risk despite preserved cognition, supporting speech as a scalable, biologically grounded biomarker for preclinical AD risk stratification.

  24. Small-Sized Reasoning Language Models for Linguistic Screening of Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-01 Digital health tools

    Alzheimer’s disease (AD) is increasing in prevalence, and early detection is essential for timely care.

  25. Night-to-night REM sleep variability: a relevant marker of early amyloid-β deposition

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2025-12-27 Brain scans and imaging

    Shorter sleep duration and greater REM sleep variability may index early AD-related brain changes, warranting longitudinal studies to establish their prognostic significance.

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