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  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
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In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Occupational complexity and cognition in the FINGER multidomain intervention trial

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2022-02-09 Risk factors

    Higher levels of occupational complexity were associated with better baseline cognition.

  2. The relationship between cognitive engagement and better memory in midlife

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2022-02-09 Risk factors

    Educational attainment and leisure activity engagement were individually associated with memory performance.

  3. Cardiovascular Risk Associated with Poorer Memory in Middle-Aged Adults from the Healthy Brain Project

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Journal of Alzheimer's disease : JAD 2022 Risk factors

    Higher number of CVRF was associated with poorer attention (β= -0.042, p = 0.039) and memory (β= -0.080, p < 0.001), but not with subjective cognitive function.

  4. Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer's Disease Dementia

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. International journal of environmental research and public health 2021-11-19 Risk factors

    The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia.

  5. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2021-09-30 Cognitive tests and assessment

    BRANCH reliably captures meaningful cognitive information remotely, suggesting promise as a digital cognitive marker sensitive early in the AD trajectory.

  6. A Brief Digital Cognitive Assessment for Detection of Cognitive Impairment in Cuban Older Adults

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Journal of Alzheimer's disease : JAD 2021-01-01 Cognitive tests and assessment

    The BHA has excellent performance characteristics in detecting cognitive impairment including dementia and MCI in a Hispanic population in Cuba and outperformed the MoCA.

  7. Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The British journal of ophthalmology 2020-11-26 Brain scans and imaging

    284 eyes of 159 subjects (222 eyes from 123 cognitively healthy subjects and 62 eyes from 36 subjects with AD) were used to develop the model.

  8. Combination of snapshot hyperspectral retinal imaging and optical coherence tomography to identify Alzheimer's disease patients

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's research & therapy 2020-11-10 Brain scans and imaging

    Hyperspectral data and retinal nerve fiber layer thickness data were used in a linear discriminant classification model to discriminate between AD patients and controls.

  9. The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-09-13 Digital health tools

    A Brain Chart quantifying brain-aging trajectories was established, enabling the systematic evaluation of individuals' brain-aging patterns relative to this large consortium.

  10. MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Brain : a journal of neurology 2020-07-01 Digital health tools

    Deep learning has emerged as a powerful approach to constructing imaging signatures of normal brain ageing as well as of various neuropathological processes associated with brain diseases.

  11. Improving the resistance and resilience framework for aging and dementia studies

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's research & therapy 2020-04-14 Risk factors

    While the field advances towards consensus definitions of existing concepts, the resistance vs resilience terminology may provide clarity in the communication of results in aging and dementia studies as well as provide a framework for the development of both hypotheses and study designs.

  12. Scalable diagnostic screening of mild cognitive impairment using AI dialogue agent

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Scientific reports 2020-03-31 Cognitive tests and assessment

    The search for early biomarkers of mild cognitive impairment (MCI) has been central to the Alzheimer's Disease (AD) and dementia research community in recent years.

  13. Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Brain : a journal of neurology 2020-01-01 Brain scans and imaging

    This study investigated differences in retrospective cognitive trajectories between amyloid and tau PET biomarker stratified groups in initially cognitively unimpaired participants sampled from the Wisconsin Registry for Alzheimer's Prevention.

  14. Physical Inactivity is Liable to the Increased Cardiovascular Risk and Impaired Cognitive Profile

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Current Alzheimer research 2020 Risk factors

    A high rate of physical inactivity was found among those enrolled in this project.

  15. Education does not protect cognitive function from brain pathology in the ADNI 2 cohort

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurobiology of aging 2019-12-05 Risk factors

    Educational attainment is widely accepted as a cognitive reserve variable.

  16. Cognitive Reserve from the Perspective of Preclinical Alzheimer Disease: 2020 Update

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Clinics in geriatric medicine 2019-11-15 Risk factors

    The concept of cognitive reserve (CR) was proposed to account for the discrepancy between levels of brain pathologic process or damage and clinical and cognitive function.

  17. Mobility assessment in people with Alzheimer disease using smartphone sensors

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Journal of neuroengineering and rehabilitation 2019-08-14 Cognitive tests and assessment

    Our findings indicate that AD patients present impairments in some key functional abilities, such as gait, turning and sitting, sit to stand, and reaction time, both in mild and moderate AD.

  18. Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Journal of the American Heart Association 2019-07-31 Genetics

    APOE-ε4 carrier status appears to modify the cross-sectional association between cardiac output and neuropsychological performance such that lower cardiac output relates to poorer performances among carriers of the ε4 allele.

  19. Effect of aerobic exercise on white matter microstructure in the aging brain

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Behavioural brain research 2019-07-04 Prevention trials

    Aging is associated with decline in white matter (WM) microstructure, decreased cognitive functioning, and increased risk of Alzheimer's disease and related dementias.

  20. Brain MRI findings related to Alzheimer's disease in older African American adults

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Progress in molecular biology and translational science 2019-05-15 Disparities

    Although a substantial body of research has identified brain MRI measures as important markers of Alzheimer's disease (AD) risk, progression, and treatment response, most of that research has been performed in non-Hispanic white American populations, leading to questions about the utility of the brain MRI measures among individuals of other races or ethnicities.

  21. Defining Cognitive Reserve and Implications for Cognitive Aging

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Current neurology and neuroscience reports 2019-01-09 Risk factors

    RECENT FINDINGS: Evidence to date supports the notion that higher levels of CR, as measured by proxy variables reflective of lifetime experiences, are associated with better cognitive performance, and with a reduced risk of incident mild cognitive impairment/dementia.

  22. Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Therapeutic advances in chronic disease 2018-11-09 Risk factors

    The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age.

  23. Evaluating Cognitive Reserve Through the Prism of Preclinical Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Psychiatric clinics of North America 2017-12-07 Risk factors

    The concept of cognitive reserve (CR) was proposed to account for the discrepancy between levels of brain pathologic features or damage and clinical and cognitive function.

  24. Aberrant Intrinsic Activity and Connectivity in Cognitively Normal Parkinson's Disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Frontiers in aging neuroscience 2017-06-19 Brain scans and imaging

    The results revealed abnormally increased and decreased ALFF and ReHo in PD-CN patients within the default mode network (posterior cingulate, inferior parietal cortex, parahippocampus, entorhinal cortex), sensorimotor cortex (primary motor, pre/post-central gyrus), basal ganglia (putamen, caudate), and posterior cerebellar lobule VII, which mediates cognition.

  25. Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-01-23 End-of-life care

    This study supports the conclusions that diabetes increases the risk of cerebrovascular but not Alzheimer's disease pathology, and at least some of diabetes' relationship to cognitive impairment may be modified by neuropathology.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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