Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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37/100
Most persons with dementia in the U.S. die in long-term care communities.
Why it matters
Interviews with 25 informal caregivers of recently deceased assisted living residents with advanced dementia found that most residents were on hospice at death, and that teamwork among staff and hospice workers was important to quality of care. Others described lack of coordination, conflict, and a need for more communication about everyone's role at the end of life.
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(1) To investigate the association between age at diabetes diagnosis and the incidence of all-cause dementia (ACD), Alzheimer’s disease (AD), and vascular dementia (VD) in individuals with diabetes.
Why it matters
In this UK Biobank cohort, people diagnosed with diabetes at age 50 or older had a lower risk of all-cause dementia than those diagnosed before age 50, including among APOE ε4 carriers. The study reports an association between age at diabetes diagnosis and dementia risk, not a treatment or prevention strategy.
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37/100
Hospice use (2011-2021) for decedents with cancer and dementia by ethnic and racial groups.
Why it matters
This study examines trends in hospice use among older adults with dementia and cancer by race and ethnicity from 2011 to 2021. The provided text gives no findings beyond this description, so no conclusion about treating, curing, or preventing Alzheimer's disease can be drawn from it.
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Oxidative stress is deeply involved in multiple pathological processes of VaD.
Why it matters
This review describes how oxidative stress contributes to vascular dementia through mechanisms including mitochondrial dysfunction and impaired antioxidant pathways, and discusses therapeutic strategies from traditional antioxidants to newer approaches. It provides a theoretical framework for treatment but does not report results from a clinical trial.
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Beyond these practical challenges, caregivers often endure significant physical exhaustion and sleep deprivation from the unrelenting demands of caregiving, which can lead to chronic fatigue and deteriorating health (Liu et al., 2022; Mao et al., 2024).
Why it matters
This paper describes the strain dementia places on family caregivers in China, including physical exhaustion, sleep deprivation, and financial pressure. It calls for expanding respite care services and assistive technologies to reduce the physical and emotional stress caregivers face.
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Dementia poses major challenges to healthcare worldwide.
Why it matters
This review explores the potential of large language models to enhance dementia diagnosis, monitor symptom progression, and provide personalised care recommendations. It states that research into these applications is in its infancy and does not report any treatment, cure, or prevention.
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In UKB, PRS cancer was nominally associated with improved fluid intelligence ( β : 0.12, 95% CI: 0.01-0.22).
Why it matters
A genetic score for cancer risk was nominally associated with better fluid intelligence in one cohort but not associated with cognitive outcomes in another. The findings were not conclusive, and no protective effect against cognitive decline was established.
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Significant predictive performance was observed for several neurocognitive disorders.
Why it matters
Machine learning applied to electrocardiograms showed significant predictive performance for dementia and Alzheimer's disease, with external AUROC values of 0.865 and 0.863 respectively. These findings suggest ECG holds promise as a non-invasive biomarker for early detection and monitoring, but this does not treat, cure, or prevent Alzheimer's disease.
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37/100
We observed adults aged 50 years and older from the UK Biobank over a median observational period exceeding two years following COVID-19 infection.
Why it matters
In UK Biobank adults aged 50 and older, COVID-19 survivors had a higher likelihood of new-onset dementia than uninfected controls, driven mainly by vascular dementia rather than Alzheimer's disease, though the risk did not exceed that of people with non-COVID respiratory illnesses. This is an observational risk association and does not test any treatment, cure or prevention.
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Diagnosis of LBD had high specificity but low sensitivity, with fewer than half of autopsy-confirmed cases having received an LBD diagnosis.
Why it matters
This study found that Lewy body dementia is often misdiagnosed as Alzheimer's disease, with fewer than half of autopsy-confirmed cases having received a Lewy body dementia diagnosis. It highlights the need to improve diagnosis, which may be helped by emerging biomarkers, but it does not test any treatment or cure.
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The calibration models for photopic lux and correlated color temperature demonstrated strong accuracy, with an adjusted R² of 0.858 and 0.982, respectively, ensuring reliable sensor measurements.
Why it matters
Wearable sensors combined with calibration and predictive modeling accurately assessed personal circadian light exposure in nursing home residents, with a random forest model achieving an adjusted R² of 0.915. This supports lighting-related health care research but does not address treating, curing, or preventing Alzheimer's disease.
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Rather than being the direct result of physical hazards, disasters emerge through socially constructed systems of vulnerability shaped by governance failures, structural inequalities, and historical injustices (Blaikie et al., 2014;Tierney, 2014;Gaillard, 2010).
Why it matters
This paper is about embedding African philosophy into disaster risk reduction and management, not Alzheimer's disease, so it provides no information on Alzheimer's treatment, cure or prevention. It discusses how communities use mutual aid and other practices in disaster preparation and response.
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37/100
BackgroundA growing number of older adults in the United States have multiple chronic conditions which contribute to decreased functional ability and increased healthcare utilization.
Why it matters
Interviews with 22 Medicare Advantage beneficiaries and caregivers who declined palliative care, plus focus groups with 5 staff, found mixed understanding of what palliative care is, with some believing it was the same as or pre-hospice. This concerns how palliative care is explained and whether people engage with it, not treatment, cure or prevention of dementia.
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37/100
ObjectiveThe Montreal Cognitive Assessment (MoCA) Memory Index Score (MIS) is a supplemental assessment of memory composed of word list delayed free-recall followed by step-down category cued- and multiple-choice cued-recall.
Why it matters
This scoping review found limited reporting on the diagnostic or prognostic utility of the MoCA Memory Index Score, with initial findings suggesting it may aid in identifying episodic memory impairment and differentiating suspected dementia etiology. However, evidence is insubstantial for predicting progression, and further research is needed.
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The study resulted in the creation of nine storytelling packs, each containing five stories tailored to specific caregiver personas.
Why it matters
Researchers created nine storytelling packs with five stories each, in German, Turkish, and English, for family caregivers of Turkish people living with dementia. Pretests suggested the stories resonated with caregivers, but the authors say future research should explore their long-term impact.
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Of 22 total CCMs, 12 participated in this study (employed as a CCM for a median [IQR] of 2 [1-3] years; 12 [100%] female) and identified populations that they perceived to especially benefit from the program, including PLWD, patients in hospice, and patients living in group homes.
Why it matters
This qualitative study interviewed care coordinators about a program that helps assisted living residents with dementia when they go to the emergency department. It addresses care coordination and patient experience, not treating, curing or preventing Alzheimer's disease.
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Black participants had low (vs high) OP, which predicted worse episodic memory and global cognition (4% to 7% mediated).
Why it matters
Lower occupational position among Black participants predicted worse episodic memory and global cognition, mediating 4% to 7% of racial cognitive disparities, while occupational complexity did not mediate them. The authors suggest policies targeting workforce inequities may reduce disparities, but this does not test any treatment, cure, or prevention.
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Eighty participants completed round one of the Delphi survey and 55 (68.75%) also completed round two.
Why it matters
This modified Delphi study identified 45 education priorities for healthcare professional students' delirium education, with prevention, diagnosis and treatment ranked most highly. Priorities related to pathophysiology and health promotion were ranked lowest, and the final set may help inform delirium education development.
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Four main themes were identified: (1) reasons family caregivers may not choose formal care, (2) perceived benefits of formal care, (3) how family caregivers choose formal care, and (4) recommendations for delivering information about formal care options.
Why it matters
Interviews with Hispanic/Latino family dementia caregivers identified reasons they may avoid formal care, its perceived benefits, how they choose it, and how information should be delivered. The study is groundwork for future decision-support interventions, not a test of one.
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The incidence of dementia declined by 26% percent (95% confidence interval: -26.2; -25.3), from 2020 per 100 000 insured individuals in 2015 to 1500 per 100 000 in 2022.
Why it matters
In German primary care claims data, the incidence of diagnosed dementia declined by 26% and prevalence by 18% from 2015 to 2022, despite population aging. The authors state that further analysis is needed to determine whether this reflects lower individual risk, changes in diagnostic behavior, or structural factors such as a shift to specialized memory clinics.
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Twenty-eight caregivers completed the intervention, which increased caregiver mastery and decreased stress and burden.
Why it matters
This feasibility trial found that an environmental cueing intervention for rural caregivers of persons with dementia improved caregiver mastery, decreased stress and burden, and improved functional performance of the person with dementia. It is a small open-label trial and did not test whether the intervention prevents or cures Alzheimer's disease.
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A comparative analysis of dysphagia pathologies across the three dementia types revealed a relatively mixed picture of various dysphagia findings in all dementia types.
Why it matters
This study of oropharyngeal dysphagia in patients with dementia found a mixed picture of dysphagia findings across dementia types, with residue the most frequent finding and aspiration the least prevalent, and no distinct endoscopic dysphagia pathologies across dementia types. It reports a higher prevalence of bolus penetration and complex dysphagia in Parkinson's-related dementia, but this concerns swallowing problems, not treating, curing, or preventing Alzheimer's disease.
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Across 58 studies, 38 had an observational design and predominantly used questionnaires to measure cognitive and social activities.
Why it matters
This scoping review found wide variation in how cognitive and social activities are measured across studies, leading to fragmented insights into which activities protect against dementia. It does not test any treatment, cure or prevention for Alzheimer's disease.
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Personal support workers (PSWs) in long-term care (LTC) homes provide the most care to people living with dementia, yet receive the least education compared to other healthcare professionals.
Why it matters
This qualitative study of personal support workers in long-term care identified learning needs including understanding dementia, addressing responsive behaviours, person-centred communication and delirium. It is about education and training for care staff, not about treating, curing or preventing Alzheimer's disease.
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We identified three main themes of palliative hope in late-stage dementia: 1) Life is good and there is still time, 2) Agency and identity are not lost, and 3) Death will be good and professional support is available.
Why it matters
This analysis describes how nursing home staff can build and maintain hope with families of residents in late-stage dementia, focusing on themes such as life still being good and the possibility of a peaceful death. It is about communication and palliative support, not about treating, curing or preventing Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Clinical phenotype of dementia after traumatic brain injury
- The Association between Glaucoma and Dementia in a National Cohort of All of Us Participants
- Prevalence and prognostic value of Delirium as the initial presentation of COVID-19 in the elderly with dementia: An Italian retrospective study
- Association of sugar intake with incident dementia in the UK Biobank: a prospective cohort study
- Preeclampsia and eclampsia: the conceptual evolution of a syndrome
- HIV-associated nephropathy
- Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline
- Age-related hearing loss and dementia risk across the lifespan: mechanisms, equity, and prevention
- Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults
- Hippocampus segmentation in MR images using atlas registration, voxel classification, and graph cuts