Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Factors predicting the early institutionalization of demented patients were studied in 143 outpatients using univariate and multivariate life-table methods.
Why it matters
Among 143 dementia outpatients followed for 19 ± 12 months, 51 moved into an institution; paranoia, aggressive behavior and incontinence were the strongest predictors, and who the caregiver was (spouse or child, male or female) made no difference in this sample. The authors argue that because troublesome behaviors are "potentially treatable," managing them "should be a major focus of therapy in dementia" — but this was an observational study, so it shows these problems predict placement, not that treating them delays it.
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Why it matters
Describes the Rotterdam Elderly Study, which looks at the determinants of disease and disability in older people.
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Why it matters
Reports observations on the brains of older people with dementia.
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Eighty patients were included (mean age: 81 years, interquartile range 74-86 years; 36.2% female, ∼80% with dementia and Alzheimer disease).
Why it matters
In memory clinic patients, both Boston Criteria versions showed only modest overall diagnostic performance against neuropathology, with no clear overall gain in accuracy for the newer version. These findings support cautious interpretation of MRI-based criteria and highlight the need for additional biomarkers.
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= 0.039) were associated with better global cognition.
Why it matters
This study found no significant link between nine sleep measures and dementia risk, but longer, more consolidated sleep and stronger slow oscillation-spindle coupling were linked to better cognitive performance. The results do not support sleep measures as direct predictors of dementia risk, though they may still be useful for guiding further research.
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Older patients with kidney failure residing in high-disadvantage neighborhoods, particularly Black patients and those in suburban, rural, or small-town areas, had a higher risk of ADRD compared with those in low-disadvantage neighborhoods.
Why it matters
This cohort study found that older patients with kidney failure in high-disadvantage neighborhoods had a higher risk of Alzheimer's disease and related dementias diagnoses, with the association differing by race and ethnicity. The findings concern neighborhood disadvantage as a risk factor and do not test any treatment, cure, or prevention.
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Among 6303 hospitalized patients with ADRD, 39.3% had mild dementia, 57.8% moderate, and 2.9% severe.
Why it matters
Among 6,303 hospitalized patients with dementia, moderate-stage dementia was most common, and moderate or severe dementia was more likely in older patients, Black patients and those with Alzheimer's disease. This describes hospital patient characteristics, not a treatment or cure.
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Of 219 completing participants (mean age 73.5 years), the mean SUS score was 82.0 (95% CI: 80.3-83.8), with 84% exceeding the usability threshold (SUS score > 68).
Why it matters
In this 8-week study of 219 participants with mild cognitive impairment or early dementia, the INFORMA computerized cognitive stimulation platform showed high usability and satisfaction. The authors say further studies are needed to test its therapeutic efficacy.
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Mild cognitive impairment (MCI) is an early stage in the progression toward dementia.
Why it matters
This lipidomic study found differences in lipids from saliva, plasma, and feces between people with mild cognitive impairment and healthy controls, identifying candidate biomarkers. It is about biomarker discovery and does not show that targeting these lipids treats, cures, or prevents Alzheimer's disease.
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Across both cohorts, individuals with lower SES generally exhibited higher BERs (worse performance) than high SES groups, confirming the presence of bias.
Why it matters
This study found that AI models predicting dementia performed worse for people with lower socioeconomic status, showing bias in the models. Balancing the training data reduced this disparity for one measure of socioeconomic status but sometimes made it worse for other measures, and sometimes slightly lowered overall model performance.
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Pre-post evaluations revealed significant reductions in physical symptoms, psychosocial-spiritual distresses and information insufficiency of patients in the first three months of service.
Why it matters
This pre-post evaluation of an interdisciplinary end-of-life care model in Hong Kong residential care homes found significant reductions in physical symptoms, psychosocial-spiritual distress, and information needs in the first three months. Patients with dementia had improvements comparable to other patients.
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As of October 2025, we have recruited 200 participants.
Why it matters
This is a protocol for an ongoing randomized controlled trial testing a virtual nurse-led palliative care intervention, with 200 participants recruited as of October 2025. No results on treating, curing or preventing Alzheimer's disease are reported.
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FTD patients demonstrated significantly reduced retinal and choriocapillaris perfusion compared to CU (all p < 0.001).
Why it matters
In this cross-sectional study, people with frontotemporal dementia had reduced retinal and choriocapillaris perfusion compared to controls, and these retinal changes correlated with cerebral small vessel disease burden. The findings suggest OCTA could be a noninvasive biomarker for monitoring vascular contributions, but no treatment or prevention is tested.
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We estimated the prevalence of dementia at 6.7% [95% confidence interval (CI): 5.4-8.0] and MCI at 10% (95% CI: 8.7-11.7).
Why it matters
This study estimated the prevalence of dementia at 6.7% and mild cognitive impairment at 10% in the Mexican population, with older age, lower education, rural residence, and cardiovascular disease associated with higher odds. The findings suggest an unequal burden of cognitive impairment among the aging Mexican population.
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The NIA hopes to see continued collection and harmonization of the International HRS and HCAP data, as well as continued use of the data to advance our knowledge of how behavioral and social factors influence aging and life course outcomes, including those related to AD/ADRD.
Why it matters
This paper is an NIA perspective calling for continued collection and harmonization of International Health and Retirement Studies and Harmonized Cognitive Assessment Protocol data to study behavioral and social factors in aging and dementia. No new data were generated or analyzed, and no treatment or prevention is tested.
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Current metabolomic aging clocks inadequately capture individual heterogeneity in biological aging trajectories, constraining their clinical utility.
Why it matters
This UK Biobank study built a metabolomic aging clock that was linked to seven cardiovascular diseases but not to dementia. The clock may help predict cardiovascular risk, but it showed no association with dementia in this analysis.
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There were 361 deaths. Median survival was longer for residents with advanced dementia and frailty (16.5 months, 95%CI:13.5–19.5 months, P < 0.001) compared to incurable cancer (8.1 months, 95%CI:5.1–11.1 months, P < 0.001) and end-stage organ failure (7.7 months, 95%CI:3.0-12.4 months, P < 0.001).
Why it matters
This retrospective cohort study found that nursing home residents with advanced dementia and frailty lived longer and received fewer in-person reviews in the last six months of life than residents with incurable cancer or end-stage organ failure. It concerns palliative care service planning, not treating, curing or preventing Alzheimer's disease.
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The incidence of POD was 8.2% (26 of 316).
Why it matters
This study found that saccadic eye movement parameters predicted postoperative delirium in elderly arthroplasty patients more accurately than MMSE and MoCA scores or neurofilament light chain levels. It suggests saccadic parameters may serve as a complementary behavioural biomarker for predicting postoperative delirium.
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Among 32,430 individuals (mean age at first hospital encounter 76.6±10.9 years; 59.1% female; 4.2% African American; 5.0% Hispanic), only 16.0% received an MCI diagnosis before their dementia diagnosis.
Why it matters
Among 32,430 individuals, only 16.0% received an MCI diagnosis before their dementia diagnosis, and African American and Hispanic patients had 31% and 44% lower odds of receiving an MCI diagnosis before dementia compared to White non-Hispanic patients. These findings are about who gets diagnosed early, not about treating, curing, or preventing Alzheimer's disease.
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Of 1,073 caregivers, 33% reported high baseline strain.
Why it matters
Among 1,073 dementia caregivers, 33% reported high baseline strain, and high-strain caregivers had 60% higher odds of reporting that COVID-19 affected their caregiving. County-level COVID-19 burden did not significantly change these relationships.
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The rising prevalence of mild cognitive impairment (MCI) and dementia, combined with persistent underdiagnosis, is driving an increased need for scalable cognitive assessment tools.
Why it matters
These recommendations from a workgroup define preferred characteristics for digital cognitive assessments in three clinical contexts: initial detection, diagnostic support, and characterising cognitive profiles. They concern assessment standards and do not report any treatment, cure or prevention.
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= 49.17) had a higher incidence of psychotic disorder (p = .028) compared to non-progressors and progressors.
Why it matters
Among adults with Down syndrome and mild cognitive impairment, 31.6% did not progress to dementia despite high amyloid levels, and those with plateaued decline had more medical conditions and life stressors. The findings suggest that reversible factors can lead to misdiagnosis of prodromal Alzheimer's, and primary care physicians should address them.
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224 subjects progressed to dementia (SCD=38 (9.72%), MCI=186 (50.8%)).
Why it matters
In this study, brain age gap predicted progression to dementia in people with subjective cognitive decline and mild cognitive impairment. Its predictive value was strongest in subjective cognitive decline, where vascular risk scores provided no added value.
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45/100
When systematically reviewed using the USDA Nutrition Evidence Systematic Review method and an a priori established protocol, a common theme emerged: diets characterized by higher consumption of vegetables, fruits, legumes, nuts, fish, seafood, and unsaturated vegetable oils, alongside lower intake of red and processed meats and sugar-sweetened beverages, are consistently associated with a reduced risk of cognitive decline and dementia.
Why it matters
This systematic review of 139 studies found that diets higher in vegetables, fruits, legumes, nuts, fish, seafood, and unsaturated vegetable oils, with lower intake of red and processed meats and sugar-sweetened beverages, are consistently associated with reduced risk of cognitive decline and dementia. It notes a significant knowledge gap about the critical timing and duration of dietary pattern consumption in early adulthood and that the biological mechanisms remain unclear.
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45/100
We included 150 patients; 67.3% met criteria for PC need.
Why it matters
This cross-sectional study of 150 hospital patients found that 67.3% met criteria for palliative care need, with dementia and malignancy positively associated with that need. It shows a high level of palliative care need among hospitalised patients with chronic conditions, but does not test whether any treatment changes outcomes.
From across this topic
9 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Social Frailty and Social Isolation in the Context of Dementia: A Simultaneous Concept Analysis
- Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study
- The Use of Telehealth Among People Living With Dementia-Caregiver Dyads During the COVID-19 Pandemic: Scoping Review
- Donepezil for dementia due to Alzheimer's disease
- Implementing the compassion intervention, a model for integrated care for people with advanced dementia towards the end of life in nursing homes: a naturalistic feasibility study
- A Smart RFID-Driven System for Dementia Patient Tracking: A Machine Learning Approach for Monitoring and Localization
- Medicare's Annual Wellness Visit and diagnoses of dementias and cognitive impairment
- Towards Combinatorial Approaches for Preserving Cognitive Fitness in Aging
- Multifaceted role of nitric oxide in vascular dementia