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Nutritional Status is Associated With Severe Dementia and Mortality
Chelsea L. Sanders, Heidi J. Wengreen, Sarah Schwartz, Stephanie J. Behrens, Chris Corcoran, Constantine G. Lyketsos, JoAnn T. Tschanz. Alzheimer Disease & Associated Disorders, 2018
Topic: Risk, prevention and care in population studies
Compared with “well-nourished,” “malnourished” PWD had 3-4 times the hazard of severe dementia [hazard ratio (HR), 4.31; P =0.014] and death (HR, 3.04; P <0.001). Those “at risk for malnutrition” had twice the hazard of severe dementia (HR, 1.98; P =0.064) and 1.5 times the hazard of death (HR, 1.46; P =0.015). mMNA subcomponents of food group intake, weight loss, body mass index, mobility, health status, protein consumption, and mid-arm circumference predicted one or both outcomes. Nutritional status is an important predictor of clinical outcomes in dementia and may provide an avenue for intervention.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Sanders, C. L., Wengreen, H. J., Schwartz, S., Behrens, S. J., Corcoran, C., Lyketsos, C. G., et al. (2018). Nutritional Status is Associated With Severe Dementia and Mortality. Alzheimer Disease & Associated Disorders. https://doi.org/10.1097/wad.0000000000000274
Vancouver
Sanders CL, Wengreen HJ, Schwartz S, Behrens SJ, Corcoran C, Lyketsos CG, et al. Nutritional Status is Associated With Severe Dementia and Mortality. Alzheimer Disease & Associated Disorders. 2018. doi:10.1097/wad.0000000000000274.
BibTeX
@article{sanders2018-1252e390,
author = {Sanders, Chelsea L. and Wengreen, Heidi J. and Schwartz, Sarah and Behrens, Stephanie J. and Corcoran, Chris and Lyketsos, Constantine G. and Tschanz, JoAnn T.},
title = {{Nutritional Status is Associated With Severe Dementia and Mortality}},
journal = {Alzheimer Disease \& Associated Disorders},
year = {2018},
doi = {10.1097/wad.0000000000000274},
url = {https://doi.org/10.1097/wad.0000000000000274}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Compared with “well-nourished,” “malnourished” PWD had 3-4 times the hazard of severe dementia [hazard ratio (HR), 4.31; P =0.014] and death (HR, 3.04; P <0.001).
- Those “at risk for malnutrition” had twice the hazard of severe dementia (HR, 1.98; P =0.064) and 1.5 times the hazard of death (HR, 1.46; P =0.015). mMNA subcomponents of food group intake, weight loss, body mass index, mobility, health status, protein consumption, and mid-arm circumference predict
- Nutritional status is an important predictor of clinical outcomes in dementia and may provide an avenue for intervention.
Why it matters
This study found that people with dementia who were malnourished had a higher risk of severe dementia and death than those who were well-nourished. It does not test a treatment or cure, but it suggests that nutritional status may be a target for intervention in dementia care.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer Disease & Associated Disorders) |
| Journal's citation record | 1 / 4 | Alzheimer Disease & Associated Disorders: journal h-index 131 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 64 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.4 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 3.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 26 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author JoAnn T. Tschanz: h-index 58 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
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