Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Our findings suggest that older adults at higher dementia risk due to diabetes can show improvements in both cognition and disease self-management following home-based multidomain computerized cognitive training.
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Future research should focus on ways to involve people with dementia in decision-making through supported means.
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72/100
Mild cognitive impairment associated with Parkinson's disease (PD) is a risk factor for the development of dementia.
Why it matters
This meta-analysis estimated that 40% of Parkinson's disease patients have mild cognitive impairment, which is a risk factor for developing dementia, and it was linked to factors such as older age and longer disease duration. It describes prevalence and associated features, not a treatment, cure, or prevention for Alzheimer's disease.
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Adherence to the Life Simple 7 ideal cardiovascular health recommendations in midlife was associated with a lower risk of dementia later in life.
Why it matters
In this cohort, a higher cardiovascular health score at age 50 was associated with a lower risk of dementia over 25 years of follow-up. It is an observational finding about risk, not proof that improving cardiovascular health prevents dementia.
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Subjective caregiver burden is a significant risk factor for depressive symptoms in carers of older people and may precipitate clinical depression.
Why it matters
This meta-analysis of 55 studies and 9,847 carers found a large positive association between subjective caregiver burden and depressive symptoms. The association was stronger for those caring for people living with dementia than for those caring for frail older people or stroke patients.
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Participants allocated to CR received 10 weekly sessions over 3 months and four maintenance sessions over 6 months.
Why it matters
This randomised controlled trial tested individual goal-oriented cognitive rehabilitation added to usual treatment for people with mild-to-moderate dementia. It is a trial of a support programme for everyday functioning, not a treatment that cures or prevents Alzheimer's disease.
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Aerobic exercise combined with computerized cognitive training has better effects on the cognitive functional status of survivors of stroke than an active control.
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The study enrolled 181 participants (mean [SD] age, 69.6 [7.2] years; 114 [63.0%] female): 91 to the intervention arm (depression in later life [DIL] intervention) and 90 to care as usual (CAU).
Why it matters
This randomized trial enrolled 181 older adults in low- and middle-income countries to test a lay counselor intervention for prevention of major depression. It addresses depression prevention, not the treatment, cure, or prevention of Alzheimer's disease.
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Specialty palliative care consultation for hospitalized patients with late-stage dementia is feasible and promising to improve decision-making and some treatment outcomes.
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Little is known on how risk factors of younger cohorts will play out in the future burden of multi-morbidity (two or more concurrent long-term conditions).
Why it matters
This modelling study projects that multi-morbidity will increase in England between 2015 and 2035, with the proportion of people having 4 or more diseases almost doubling and two-thirds of those with 4+ diseases having mental ill-health including dementia. It reports no treatment, cure or prevention of Alzheimer's disease.
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Dementia is a major source of disability worldwide and there are currently no available disease-modifying treatments.
Why it matters
Among 37,898 older men followed for about 11 years, those with hearing loss were more likely to develop dementia (adjusted hazard ratio 1.69), and pooling 14 prospective studies gave a similar raised risk (hazard ratio 1.49). This makes hearing loss a candidate modifiable risk factor, but the study measured an association in observational data — it did not test whether treating hearing loss lowers dementia risk, and its own cohort included only men.
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As such, this meta-analytic review was conducted to examine the efficacy of cognitive intervention in individuals diagnosed with mild cognitive impairment (MCI) versus MCI controls based on performance of neuropsychological outcome measures in randomized controlled trials (RCT).
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Advance care planning was effective in reducing family carer uncertainty in decision-making concerning the care of their family member and improving perceptions of quality of care in nursing homes.
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There is a need for more high-quality outcome studies, particularly using randomized designs to control for confounding.
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We conducted a meta-analysis of the conflicting epidemiologic evidence on the association between midlife body mass index (BMI) and dementia.
Why it matters
This meta-analysis of 19 studies on 589,649 participants found that midlife obesity was associated with a higher risk of dementia. It examines a risk association and provides no treatment, cure or prevention.
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Relative to control subjects, patients had significantly smaller HCVs (standardized mean difference = -0.32 [95% confidence interval, -0.44 to -0.19]).
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Home-based CCT with adaptive difficulty and personal tailoring appears superior to more generic CCT in relation to both cognitive and non-cognitive outcomes.
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We developed and evaluated the effect of Multimodal Cognitive Enhancement Therapy (MCET) consisting of cognitive training, cognitive stimulations, reality orientation, physical therapy, reminiscence therapy, and music therapy in combination in older people with mild cognitive impairment (MCI) or mild dementia.
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Our study demonstrates the feasibility of a group-based Cognitive Rehabilitation program for patients with mild AD dementia.
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Dementia cases are on the rise and researchers seek innovative ways to prevent or ameliorate cognitive impairment in later life.
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The methods we used for intervention fidelity allowed nursing home staff to implement a goals of care decision aid intervention for advanced dementia.
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Cognitive decline and dementia represent very important public health problems that impact the ability to maintain social function and independent living.
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A 26-wk group-based exercise program combined with dual-task training improved GCF in community-dwelling older adults without dementia.
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Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood.
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The Mini-Mental State Examination (MMSE) is the best-known and the most often used short screening tool for providing an overall measure of cognitive impairment in clinical, research and community settings.
Why it matters
This review included 11 studies of 1,569 patients with mild cognitive impairment who were followed to see whether they developed dementia, using the Mini-Mental State Examination at baseline. It examines the test's ability to predict conversion to dementia, not any way to treat, cure or prevent Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment
- Language Performance of Individuals at Risk for Mild Cognitive Impairment
- Association of zinc deficiency and risk of new-onset dementia: a retrospective cohort study
- Trends in the use of advance care planning and cognitive assessment and care planning service visits: moving toward a palliative‐informed approach for ambulatory care of community‐dwelling persons with dementia and their caregivers
- Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients
- Delirium in nursing homes and long-term care facilities: findings of a scoping review of detection tools
- Haloperidol prophylaxis in critically ill patients with a high risk for delirium
- Empowering community health workers in dementia care in South Texas
- The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment
- Sex differences in modifiable risk factors of dementia and their associations with cognition