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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Prevention trials

Topic: Risk, prevention and care in population studies

Plain-language summary

Among the participants, 298 had at least one untreated or uncontrolled VRF. Significant intervention and VRF interaction (p = 0.032) indicated significant cognitive benefits in individuals with VRFs (Z score difference: 0.11; 95% confidence interval: 0.02-0.20), unlike in those without VRFs. Individuals with untreated or uncontrolled VRFs may derive greater cognitive benefits from multidomain interventions. CLINICAL TRIAL REGISTRATION NUMBER: This trial was registered with the UMIN-CTR (UMIN000038671). HIGHLIGHTS: We examined whether untreated or uncontrolled vascular risk factors (VRFs) modified the intervention effect. A significant interaction was found between the multidomain intervention and VRFs. The intervention was effective in individuals with untreated or uncontrolled VRFs. Beneficial effects on systolic blood pressure and pulse pressure were observed. Beneficial effects on high-density lipoprotein cholesterol and triglycerides were noted.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Sugimoto, T., Uchida, K., Yokoyama, Y., Onoyama, A., Noma, H., Arai, H., et al. (2025). Efficacy of a multidomain intervention in older adults with vascular risks: The Japan‐Multimodal Intervention Trial for the Prevention of Dementia (J‐MINT). Alzheimer s & Dementia. https://doi.org/10.1002/alz.70822

Vancouver

Sugimoto T, Uchida K, Yokoyama Y, Onoyama A, Noma H, Arai H, et al. Efficacy of a multidomain intervention in older adults with vascular risks: The Japan‐Multimodal Intervention Trial for the Prevention of Dementia (J‐MINT). Alzheimer s & Dementia. 2025. doi:10.1002/alz.70822. PMID: 41222037.

BibTeX

@article{sugimoto2025-41222037,
  author  = {Sugimoto, Taiki and Uchida, Kazuaki and Yokoyama, Yoko and Onoyama, Ayaka and Noma, Hisashi and Arai, Hidenori and Sakurai, Takashi and {J‐MINT study group}},
  title   = {{Efficacy of a multidomain intervention in older adults with vascular risks: The Japan‐Multimodal Intervention Trial for the Prevention of Dementia (J‐MINT)}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70822},
  pmid    = {41222037},
  url     = {https://doi.org/10.1002/alz.70822}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded high. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. High means the abstract mentions a randomized design, a meta-analysis or a systematic review. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Among the participants, 298 had at least one untreated or uncontrolled VRF.
Significant intervention and VRF interaction (p = 0.032) indicated significant cognitive benefits in individuals with VRFs (Z score difference: 0.11; 95% confidence interval: 0.02-0.20), unlike in those without VRFs.
Individuals with untreated or uncontrolled VRFs may derive greater cognitive benefits from multidomain interventions.
CLINICAL TRIAL REGISTRATION NUMBER: This trial was registered with the UMIN-CTR (UMIN000038671).
HIGHLIGHTS: We examined whether untreated or uncontrolled vascular risk factors (VRFs) modified the intervention effect.

Why it matters

This trial found that a multidomain intervention produced cognitive benefits in people with untreated or uncontrolled vascular risk factors, but not in those without them. It does not show that the intervention prevents or treats Alzheimer's disease.

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Study details

Evidence strengthHigh

How this study scored 38/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 36 of the 96 points we could judge it on, which is 38 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	0 / 3	National Center for Geriatrics and Gerontology: institution h-index 249 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41222037)
Free to read	2 / 2	Free to read
Points	36 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 36 of the 96 points we could judge it on is 38 out of 100.
Total	38 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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