Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Global efforts to improve the health of women largely focus on improving sexual and reproductive health.
Why it matters
This paper argues that the greatest burden of death and disability among women now comes from non-communicable diseases including dementia. It notes that most medical research was historically done in men, so sex differences in health and disease have long been unknown or ignored.
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Alzheimer's disease (AD) is the most common type of dementia among the elderly.
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We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's disease (AD) that requires closer attention in the development of AD therapeutics.
Why it matters
This paper proposes that brain energy deficit, specific to glucose, is an important pre-symptomatic feature of Alzheimer's disease, while brain uptake of ketones remains the same in Alzheimer's disease and mild cognitive impairment as in healthy controls. The authors suggest that the brain energy deficit needs to be overcome in order to successfully develop more effective therapeutics for Alzheimer's disease.
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Cognitive decline is an increasingly important public health problem, with more than 100 million adults worldwide projected to develop dementia by 2050.
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43/100
True predictors can be identified by repeatedly dividing data into fitting/validating subsets and referring the final model based on summarizing results.
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Advance care planning can assist patients to achieve a sense of control and 'peace of mind' and facilitates important family discussion.
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43/100
Hypertension is a highly prevalent condition with numerous health risks, and the incidence of hypertension is greatest among older adults.
Why it matters
This review highlights that hypertension in older adults carries risks beyond cardiovascular disease, including dementia, physical disability, and falls. It discusses potential treatment strategies and future research areas but does not test any specific treatment or prevention for Alzheimer's disease.
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Dementia SMRs were higher in northern than central or southern Italy.
Why it matters
This study found that dementia death rates vary by latitude and region, but the pattern differs between the northern and southern hemispheres and between men and women. It does not test any treatment or prevention, so it cannot show how to cure or prevent dementia.
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When an individual has dementia, family members are involved in many care transitions in their roles as caregivers.
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ACP is a multifactorial process, which may lean on professional caregivers' guidance.
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The purpose of this scoping review was to examine the science related to non-pharmacological interventions designed to slow decline for older adults with Mild Cognitive Impairment or early-stage dementia.
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Decreased olfactory function is very common in the older population, being present in >50% of individuals aged between 65 and 80 years and in 62-80% of those >80 years of age.
Why it matters
This review notes that impaired odour identification is associated with decreased cognitive abilities and memory decline, and that in mild cognitive impairment olfactory impairment may signal progression to dementia. It suggests smell loss could serve as an early warning of neurodegenerative disorders including Alzheimer's disease, but does not establish any treatment or prevention.
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Despite the fact that pain is the most common complaint at the end of life, pain management may be suboptimal for some primary diagnoses.
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The study findings demonstrate high user satisfaction with telehealth in a rural memory clinic and the sound psychometric properties of the TeSS in this population.
Why it matters
This study evaluated the reliability and validity of a telehealth satisfaction scale used in a rural memory clinic and reported on patient and caregiver satisfaction with telehealth appointments. It concerns the quality of remote care delivery and does not test any treatment, cure, or prevention for Alzheimer's disease.
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The aim of this paper was to investigate the association of three well-recognised dietary patterns with cognitive change over a 3-year period.
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The current practice of palliative care in Belgium is far from the presently considered ideal palliative care approaches.
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Noncommunicable diseases (NCDs) account for the largest burden of early mortality and are predicted to cost the global community more than US $30 trillion over the next 20 years.
Why it matters
This paper states that recent evidence indicates unhealthy diets are risk factors for mental disorders, particularly depression and dementia, and argues for government policy action to improve the food environment. It is a policy discussion and does not report a trial showing that any food policy prevents or treats Alzheimer's disease.
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We systematically reviewed randomized clinical trials of problem-solving therapy (PST) in older adults.
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The decision-support intervention piloted in this study was feasible and relevant for surrogate decision-makers of persons with advanced dementia in NHs, and it improved quality of communication between SDM and NH providers.
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This study examined trends in rural-urban disparities in all-cause and cause-specific mortality in the USA between 1969 and 2009.
Why it matters
This study of U.S. death records from 1969 to 2009 found that death rates rose with increasing rurality and that rural-urban gaps widened over time. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Loss of cognitive function is one the most devastating manifestations of ageing and vascular disease.
Why it matters
This review states that hypertension is the most important modifiable vascular risk factor for cognitive decline and dementia, contributing to small and large vessel disease and brain damage. It reviews mechanisms and the potential role of antihypertensive therapy, but does not itself show that lowering blood pressure prevents dementia.
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To understand family members' perspectives on person- and family-centered end-of-life care provided to nursing home (NH) residents with advanced dementia, we conducted a qualitative follow-up interview with 16 respondents who had participated in an earlier prospective study, Choices, Attitudes, and Strategies for Care of Advance Dementia at End of Life (CASCADE).
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Health and social care professionals can build on people's preferences for informal planning by exploring the assumptions underlying them, providing information about the possible illness trajectory and discussing the options of care available.
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43/100
Forty-three consecutive patients were enrolled (86% Richardson's syndrome).
Why it matters
This retrospective study of 43 patients with clinically diagnosed progressive supranuclear palsy found that older age at onset, early dysphagia and early cognitive deficits predicted shorter survival. It is about prognosis in this disease and does not test any treatment, cure or prevention.
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The prevalence of end-of-life discussions varied across the four countries.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Understanding Susceptibility to Breast Cancer: From Risk Factors to Prevention Strategies
- Different cognitive profiles for single compared with recurrent fallers without dementia
- Older Adults' Reasons for Using Technology while Aging in Place
- Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies
- Dementia care management in primary care practices: a descriptive study among nurse practitioners
- Patterns of chronic multimorbidity in the elderly population
- Head injury and 25-year risk of dementia
- The role of cognitive activity in cognition protection: from Bedside to Bench
- Consistency of a Dementia Diagnosis Between Systems for Patients Receiving Care Through the VA, Traditional Medicare, and Medicare Advantage
- Superficial siderosis in the general population