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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Prevention trials

Topic: Risk, prevention and care in population studies

At baseline, MCI participants displayed elevated levels of IL-17A, CX3CL1, CCL11, with a borderline increase of IL-6 and TNFα. Following the TTB intervention, we observed reductions in IL-6, IL-17A, TNFα, and CCL11 levels. In contrast, anti-inflammatory cytokines (IL-10, TGFβ, IL-4) and BDNF declined in control group but were maintained or increased in the intervention group. The TTB intervention not only improved cognitive and physical outcomes but also modulated key immune markers associated with neuroinflammation and aging. IL-10, in particular, emerged as potential peripheral biomarker of training efficacy. These findings support the utility of immune profiling in monitoring response to multidomain interventions and guiding personalized strategies for cognitive risk reduction.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Desiato, G., Bosco, P., Cintoli, S., Biagi, L., Braschi, C., Del Nero, C., et al. (2025). An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training. Brain Behavior & Immunity - Health. https://doi.org/10.1016/j.bbih.2025.101062

Vancouver

Desiato G, Bosco P, Cintoli S, Biagi L, Braschi C, Del Nero C, et al. An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training. Brain Behavior & Immunity - Health. 2025. doi:10.1016/j.bbih.2025.101062. PMID: 40746966.

BibTeX

@article{desiato2025-40746966,
  author  = {Desiato, Genni and Bosco, Paolo and Cintoli, Simona and Biagi, Laura and Braschi, Chiara and Del Nero, Chiara and Minichiello, Immacolata and Noale, Marianna and others},
  title   = {{An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training}},
  journal = {Brain Behavior \& Immunity - Health},
  year    = {2025},
  doi     = {10.1016/j.bbih.2025.101062},
  pmid    = {40746966},
  url     = {https://doi.org/10.1016/j.bbih.2025.101062}
}

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Key findings

At baseline, MCI participants displayed elevated levels of IL-17A, CX3CL1, CCL11, with a borderline increase of IL-6 and TNFα.
Following the TTB intervention, we observed reductions in IL-6, IL-17A, TNFα, and CCL11 levels.
In contrast, anti-inflammatory cytokines (IL-10, TGFβ, IL-4) and BDNF declined in control group but were maintained or increased in the intervention group.
The TTB intervention not only improved cognitive and physical outcomes but also modulated key immune markers associated with neuroinflammation and aging.
IL-10, in particular, emerged as potential peripheral biomarker of training efficacy.

Why it matters

This study found that people with mild cognitive impairment had elevated inflammatory markers at baseline, and that a physical and cognitive training intervention reduced some of these markers while maintaining or increasing anti-inflammatory cytokines and BDNF. It does not show whether this intervention prevents or treats Alzheimer's disease.

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Study details

Participants76
Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Brain Behavior & Immunity - Health)
Journal's citation record	0 / 4	Brain Behavior & Immunity - Health: journal h-index 53 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	76 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Michela Matteoli: h-index 74 (OpenAlex, whole career)
Institution's track record	1 / 3	National Research Council: institution h-index 840 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 9 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40746966)
Free to read	2 / 2	Free to read
Total	43 / 100	—

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