Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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To set a working cutoff score for the referral to diagnostic examination, we evaluated 150 consecutive patients with complaints potentially related to dementia, using the Mini-Mental State Examination (MMSE).
Why it matters
This study evaluated the Mini-Mental State Examination in 150 consecutive patients with complaints possibly related to dementia to set a working cutoff score for referral to diagnostic examination. It concerns using a test score to help diagnose dementia, not treating, curing or preventing it.
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Three cases of slowly progressive speech and language disturbance were studied at various points post onset (three, five and 15 years respectively).
Why it matters
This study of 3 cases of slowly progressive aphasia found the syndrome varies in symptoms and rate of progression, does not necessarily become full dementia, and was associated with abnormal left temporal lobe metabolism on PET. It describes a language syndrome and does not test any treatment, cure or prevention.
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The IQCODE is a questionnaire which asks an informant about changes in an elderly person's everyday cognitive function.
Why it matters
The IQCODE is a questionnaire that asks an informant about changes in an older person's everyday thinking. Given to 613 informants from the general population and to informants of 309 people with dementia, it showed high internal reliability, and its total score and each of its 26 items separated the two groups well. Scores had only a small correlation with education.
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A survey was made of 274 non-institutionalized persons aged 70 and over living in Hobart.
Why it matters
This community survey measured the prevalence of dementia and depression among elderly people in Hobart and how diagnostic criteria affected the rates. It is an epidemiological study and does not test any treatment, cure or prevention for Alzheimer's disease.
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Transient cognitive disorders (delirium and pseudodelirium) are highly prevalent among the elderly, especially those with brain damage.
Why it matters
This paper describes that transient cognitive disorders such as delirium are highly prevalent among the elderly and may be potentially reversible but can herald death. It emphasizes that transient cognitive disorders must not be confused with dementia, a chronic syndrome.
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Structural brain imaging is guideline-recommended for cases with newly diagnosed cognitive impairment.
Why it matters
Among about 1.1 million Medicare beneficiaries newly diagnosed with cognitive impairment in 2021, only 56.6% received a recommended structural brain scan (MRI or CT) within a year of diagnosis, with lower rates for dual-eligible beneficiaries and Medicare Advantage members. This describes gaps in diagnosis, not any treatment, cure or prevention of Alzheimer's disease.
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BackgroundAlzheimer's disease (AD) and related dementias are leading causes of death worldwide.
Why it matters
This study of 924 participants with incident dementia found that lower individual-level socioeconomic status measured by HOUSES was associated with increased mortality risk, while neighborhood-level deprivation, education, and occupation were not associated with mortality. The findings concern mortality risk factors after diagnosis, not treating, curing, or preventing Alzheimer's disease.
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The simulated cohort was informed by 111 600 PWH enrolled in Medicare at the start of 2026 (mean [SD] age, 70.9 [5.0] years; 77% male).
Why it matters
This modeling study projected the number of Medicare beneficiaries 65 and older with HIV and their costs over ten years, with most costs due to antiretroviral therapy. It contains no information on treating, curing, or preventing Alzheimer's disease.
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Multicomponent and transdisciplinary interventions focused on the family member–patient dyad have the potential to optimize cognitive outcomes and quality of life.
Why it matters
This is a protocol for a pilot randomized controlled trial testing a 12-week home-based multicomponent intervention of cognitive training, nutritional counseling, and physical exercise for older adults with mild cognitive impairment and their family study partners. It has not yet shown whether the intervention works, so it cannot yet say anything about treating, curing, or preventing Alzheimer's disease.
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Data on 214 251 respondents were included in the study.
Why it matters
This cross-national analysis found differences in the prevalence and patterns of dementia risk factors across 14 countries and regions. It supports tailoring prevention strategies to context, but it did not test whether any intervention reduces dementia.
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As disease-modifying therapies for Alzheimer's disease become available, ensuring equitable access to timely and accurate diagnosis of cognitive impairment is critical.
Why it matters
This article describes 'dementia diagnostic deserts' and 'Triple Disadvantage Zones' where rurality, primary care shortages and social deprivation combine to worsen access to diagnosis, and notes training gaps among nurse practitioners and physician assistants. It is about diagnostic inequity and does not report any treatment, cure or prevention.
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Three subtypes emerged: severe obesity-related inflammatory diabetes (SOID), mild metabolic diabetes (MMD, reference), and mild age-related hypertension-predominant diabetes (MARD-H).
Why it matters
This study identified three subtypes of type 2 diabetes, with the severe obesity-related inflammatory subtype showing higher risks of dementia, stroke, and adverse brain changes. It suggests that recognizing diabetes subtypes may help identify people at higher risk, but it does not show that treating subtypes differently prevents dementia.
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Accurate dementia risk prediction is challenging, and may be facilitated by better use of imaging and genetic data, including their complex interactions.
Why it matters
Deep survival neural networks combining imaging and genetic data predicted dementia risk better than models using only age, sex, and genetics, but did not outperform models that also included MRI markers. The authors conclude that imaging and genetic data can feasibly be integrated for risk prediction, which is about prediction rather than treatment or prevention.
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These findings identify affiliate stigma as an important risk factor for dementia caregivers’ depressive symptoms, operating through both objective and emotional forms of social disconnection.
Why it matters
Among 338 Chinese and Korean American dementia caregivers, higher affiliate stigma was associated with more severe depressive symptoms, partly explained by social isolation and especially loneliness. The authors say culturally sensitive efforts to reduce stigma and social disconnection may improve mental health outcomes, but no dementia treatment or cure was tested.
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Caregiving difficulties showed excellent reliability (α = 0.928) and yielded three components explaining 73.19% of variance.
Why it matters
This cross-sectional study of residential dementia care staff found that higher subjective workload and limited coping options were associated with greater burnout severity, while self-reported prior learning about burnout was strongly negatively associated with it. The findings concern staff wellbeing and organizational strategies, not treating, curing, or preventing Alzheimer's disease.
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BackgroundDementia disorders are affecting millions of people globally, characterized by memory loss, communication difficulties, and motor function decline.
Why it matters
Video-based gait analysis using the Timed Up and Go test under dual-task conditions distinguished people with dementia from healthy controls, with the best accuracy of 87% in the animal naming dual-task. This is a diagnostic approach and does not address treating, curing, or preventing Alzheimer's disease.
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MCI exhibited greater retinal tortuosity (p < 0.05) and sparser vasculature (p < 0.001), correlating with higher PSMD, WMH volumes, and adverse plasma biomarkers (all p < 0.05).
Why it matters
In people with mild cognitive impairment, changes in retinal blood vessels were linked to cerebral small vessel disease and cognitive decline. The authors suggest retinal imaging could be a non-invasive biomarker for early cognitive decline, but this does not yet offer a treatment or cure.
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These findings support the feasibility, tolerability, and high patient acceptability of pMRI.
Why it matters
This study tested whether a portable, low-field MRI scanner could be used in an outpatient clinic for people with neurological conditions including Alzheimer's-type dementia, and found it was tolerable and acceptable to patients. It is a feasibility study about imaging access and does not test any treatment, cure, or prevention.
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43/100
ObjectiveTo review the application of artificial intelligence (AI) in the care of older adults with disabilities, identifying intervention type, target populations, and effects.
Why it matters
This scoping review found that artificial intelligence applications for older adults with disabilities, including those with cognitive impairment or dementia, show promise in rehabilitation, companionship and reducing caregiver burden, though further development is needed. It reviews existing studies and does not test any treatment, cure or prevention.
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Our study shows that the pdp is well received by its participants, underlined by a high level of satisfaction and positive responses to what pdp offers.
Why it matters
This satisfaction survey found that participants in a dementia prevention programme in Luxembourg reported high satisfaction and would recommend it to others. It measures how the programme is received, not whether it treats, cures or prevents Alzheimer's disease.
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Event-related potentials (ERPs), particularly the P200 component, have been studied as potential biomarkers, but conventional grand-averaged approaches often yield inconsistent results.
Why it matters
In a large cohort of older adults, patients with amnestic mild cognitive impairment showed blurred and attenuated P200 responses and accelerated neural adaptation compared with cognitively normal participants. These findings suggest slope-based temporal indices may hold exploratory potential as noninvasive indicators, not a treatment or cure.
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A total of 53 stakeholders participated in focus groups and engagement sessions.
Why it matters
This project used feedback from 53 stakeholders to refine the DIGNITY program, which includes a manual, decision-making tools, and staff training to support preference-based dementia care in rural nursing homes. The authors state future research should assess its feasibility, acceptability, and impact, so no treatment or prevention effect is yet shown.
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The weighted combined PAF for all 14 risk factors was 38.9%, indicating that nearly 4 in 10 dementia cases in Japan might be preventable.
Why it matters
This analysis estimates that nearly 4 in 10 dementia cases in Japan might be preventable, with hearing loss, physical inactivity and high LDL cholesterol as the largest contributors. It suggests that preventive efforts should prioritize hearing care, physical activity and metabolic health.
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43/100
Dementia, a syndrome characterized by a decline in cognitive function beyond what is expected from normal aging, poses a significant global health challenge.
Why it matters
This meta-analysis describes a bidirectional relationship between depression and dementia, with depression acting as a modifiable risk factor for future dementia and also occurring frequently in people who already have dementia. It discusses implications and strategies for prevention but does not report a treatment or cure for Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- White paper defining optimal palliative care in older people with dementia: a Delphi study and recommendations from the European Association for Palliative Care
- Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis
- External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study
- Previous parity differentially influences cognition in later life depending on dementia status
- Dementia in Down syndrome. Untangling the threads
- Emergency Department Hallways Are Associated With Incident Delirium and Severe Agitation in Older Adults Living With Dementia
- MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder
- Benefit-Finding Intervention Delivered Individually to Alzheimer Family Caregivers: Longer-Term Outcomes of a Randomized Double-Blind Controlled Trial
- Feasibility of Telephone‐Based Cognitive Assessments and Healthcare Utilization in US Medicare‐Enrolled Older Adults Following Emergency Department Discharge
- Timing of Palliative Care Consultation and the Impact on Thirty-Day Readmissions and Inpatient Mortality