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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Risk factors

Topic: Risk, prevention and care in population studies

The weighted combined PAF for all 14 risk factors was 38.9%, indicating that nearly 4 in 10 dementia cases in Japan might be preventable. Hearing loss (6.7%), physical inactivity (6.0%), and high LDL cholesterol (4.5%) were the largest contributors. Reducing all risk factors by 10% could prevent ∼208,000 dementia cases; reducing them by 20% could prevent ∼407,000 cases. Dementia preventive efforts in Japan should prioritise hearing care, physical activity, and metabolic health. Japan-specific data confirmed that hearing loss is a leading contributor to dementia, underscoring the urgency to increase public awareness and access to hearing interventions. Funding: The Royal Danish Embassy in Japan, Danish Ministry of Foreign Affairs, Danish Ministry of Health, and Japan Agency for Medical Research and Development funded this study.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Wasano, K., & Jørgensen, K. (2026). The potential for dementia prevention in Japan: a population attributable fraction calculation for 14 modifiable risk factors and estimates of the impact of risk factor reductions. The Lancet Regional Health - Western Pacific. https://doi.org/10.1016/j.lanwpc.2025.101792

Vancouver

Wasano K, Jørgensen K. The potential for dementia prevention in Japan: a population attributable fraction calculation for 14 modifiable risk factors and estimates of the impact of risk factor reductions. The Lancet Regional Health - Western Pacific. 2026. doi:10.1016/j.lanwpc.2025.101792. PMID: 41647885.

BibTeX

@article{wasano2026-41647885,
  author  = {Wasano, Koichiro and Jørgensen, Kasper},
  title   = {{The potential for dementia prevention in Japan: a population attributable fraction calculation for 14 modifiable risk factors and estimates of the impact of risk factor reductions}},
  journal = {The Lancet Regional Health - Western Pacific},
  year    = {2026},
  doi     = {10.1016/j.lanwpc.2025.101792},
  pmid    = {41647885},
  url     = {https://doi.org/10.1016/j.lanwpc.2025.101792}
}

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Key findings

The weighted combined PAF for all 14 risk factors was 38.9%, indicating that nearly 4 in 10 dementia cases in Japan might be preventable.
Hearing loss (6.7%), physical inactivity (6.0%), and high LDL cholesterol (4.5%) were the largest contributors.
Reducing all risk factors by 10% could prevent ∼208,000 dementia cases; reducing them by 20% could prevent ∼407,000 cases.
Dementia preventive efforts in Japan should prioritise hearing care, physical activity, and metabolic health.
Japan-specific data confirmed that hearing loss is a leading contributor to dementia, underscoring the urgency to increase public awareness and access to hearing interventions.

Why it matters

This analysis estimates that nearly 4 in 10 dementia cases in Japan might be preventable, with hearing loss, physical inactivity and high LDL cholesterol as the largest contributors. It suggests that preventive efforts should prioritize hearing care, physical activity and metabolic health.

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Study details

Effect size38.9%; 6.7%; 6.0%
Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Lancet Regional Health - Western Pacific)
Journal's citation record	0 / 4	The Lancet Regional Health - Western Pacific: journal h-index 66 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 6 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.0 citations a year over 2 year(s) since 2026
Impact for its field and year	5 / 6	Cited 28.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Kasper Jørgensen: h-index 16 (OpenAlex, whole career)
Institution's track record	1 / 3	Rigshospitalet: institution h-index 882 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41647885)
Free to read	2 / 2	Free to read
Total	43 / 100	—

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