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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Digital health tools

Topic: Risk, prevention and care in population studies

Three cases of slowly progressive speech and language disturbance were studied at various points post onset (three, five and 15 years respectively). Language, neuropsychological and brain imaging (computer tomography and positron emission tomography) evaluations were completed on all three patients. The data suggest that the syndrome of "progressive aphasia": 1) does not involve a uniform symptom complex; 2) does not necessarily develop into a full blown dementia syndrome; 3) varies greatly in rate of progression from case to case; 4) is associated with normal brain structure (on computer tomography); and 5) is associated with abnormal left temporal lobe metabolism as measured by fluorodeoxyglucose (FDG) positron emission tomography (PET). One patient had histological findings consistent with Alzheimer's disease at necropsy.

Key findings

The data suggest that the syndrome of "progressive aphasia": 1) does not involve a uniform symptom complex; 2) does not necessarily develop into a full blown dementia syndrome; 3) varies greatly in rate of progression from case to case; 4) is associated with normal brain structure (on computer tomography); and 5) is associated with abnormal left temporal lobe metabolism as measured by fluorodeoxyglucose (FDG) positron emission tomography (PET).

Why it matters

This study of 3 cases of slowly progressive aphasia found the syndrome varies in symptoms and rate of progression, does not necessarily become full dementia, and was associated with abnormal left temporal lobe metabolism on PET. It describes a language syndrome and does not test any treatment, cure or prevention.

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Study details

Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry)
Journal's citation record	3 / 4	Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	1990 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (pubmed indexes it as a clinical or observational study)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 115 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.0 citations a year over 38 year(s) since 1990
Impact for its field and year	3 / 6	Cited 5.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 17 other studies in this library
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author W Hanson: h-index 31 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Southern California: institution h-index 1,521 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 1704428)
Free to read	0 / 2	Behind a paywall — scores zero
Total	44 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Kempler, D., Metter, E. J., Riege, W. H., Jackson, C. A., Benson, D. F., & Hanson, W. R. (1990). Slowly progressive aphasia: three cases with language, memory, CT and PET data. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.53.11.987

Vancouver

Kempler D, Metter EJ, Riege WH, Jackson CA, Benson DF, Hanson WR. Slowly progressive aphasia: three cases with language, memory, CT and PET data. Journal of neurology, neurosurgery, and psychiatry. 1990. doi:10.1136/jnnp.53.11.987. PMID: 1704428.

BibTeX

@article{kempler1990-1704428,
  author  = {Kempler, D. and Metter, E. J. and Riege, W. H. and Jackson, C. A. and Benson, D. F. and Hanson, W. R.},
  title   = {{Slowly progressive aphasia: three cases with language, memory, CT and PET data}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {1990},
  doi     = {10.1136/jnnp.53.11.987},
  pmid    = {1704428},
  url     = {https://doi.org/10.1136/jnnp.53.11.987}
}

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