Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,018 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
-
We used cross-sectional data from the NHANES (National Health and Nutrition Examination Survey) from 1999 to 2018 linked to National Death Index records.
Why it matters
This study examined the reliability and validity of self-reported risk factors for stroke and dementia-related mortality. It found that reliability varies between risk factors, and it does not report any treatment, cure, or prevention for Alzheimer's disease.
-
Vascular cognitive impairment (VCI) is a leading cause of age-related cognitive decline, driven by cerebrovascular dysfunction and cerebral small vessel disease (CSVD).
Why it matters
This review describes how cerebromicrovascular endothelial senescence may contribute to vascular cognitive impairment by disrupting cerebral blood flow, neurovascular coupling, the blood-brain barrier, and by promoting cerebral microhemorrhages. It notes that targeting senescent endothelial cells with senolytic therapy restored cerebrovascular function and improved cognitive outcomes in experimental models of atherosclerosis, so this is preclinical evidence, not a proven treatment for people.
-
A wMD was related to slowed EM declines across sociodemographic populations in a national U.S. sample.
Why it matters
In this 9-year study of 833 American adults, stronger adherence to a Western Mediterranean diet predicted less decline in episodic memory but did not predict executive functioning. This suggests that this dietary pattern may help slow memory decline, though it did not affect all cognitive abilities.
-
46/100
In the fully adjusted model, the cumulative odds ratios (OR) are 1.28 (95% confidence interval [CI]: 1.25–1.31) for any dementia, 1.44 (95% CI: 1.36–1.53) for Alzheimer’s disease and 1.65 (95% CI: 1.48–1.83) for vascular dementia, associated with per unit increase in annual cumulative flooding exposure over lag 0–6 years.
Why it matters
In this UK Biobank analysis, greater cumulative flood exposure was associated with higher odds of any dementia, Alzheimer's disease, and vascular dementia, with the highest risk in the year of flooding. The authors say these findings highlight the need for public health strategies to protect people in flood-prone areas.
-
Little is known about whether cognitive assessments can be completed remotely by older adults at risk for dementia, and there is no consensus on which tool is best.
Why it matters
In this secondary analysis of a randomized controlled trial, 52 participants at risk for dementia completed cognitive tests remotely via Zoom, and scores on the MoCA, CFC2, and T-CogS did not change significantly from baseline to post-intervention. The study addresses feasibility of remote cognitive testing, not treatment or prevention of dementia.
-
46/100
The findings indicate that stronger ESG practices significantly reduce corporate risk, enhance financial stability, and mitigate regulatory and market volatility exposure.
Why it matters
This study is about ESG practices, board gender diversity and corporate risk in Asian firms and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
-
Four clusters were identified: least disadvantaged (Class 1: 31.5% men; 30.6% women), most disadvantaged (Class 2: 20.2% men; 19.4% women), high social support with Class 1 features (Class 3: 22.2% men; 24.1% women), and high social support with Class 2 features (Class 4: 26.1% men; 25.7% women).
Why it matters
In this 12-year Australian cohort, socioeconomic disadvantage was associated with higher dementia risk in both men and women, and women in a high-social-support but disadvantaged cluster also had higher risk. The findings suggest social determinants of health independently predict dementia risk.
-
Of the 1216 cases reported, Alzheimer's disease (60.5%) was the most common subtype, followed by vascular dementia (24.5%).
Why it matters
This retrospective analysis of 1216 cases at a single neuropsychiatric facility in Northeastern Nigeria found that Alzheimer's disease was the most common subtype and hypertension the most frequent comorbidity. The authors highlight an urgent need for better diagnostic tools and health care infrastructure to address dementia in this resource-constrained setting.
-
46/100
Vascular dementia (VaD) is the second leading cause of dementia after Alzheimer's disease (AD).
Why it matters
This narrative review covers vascular dementia, the second leading cause of dementia after Alzheimer's disease. It reports that no FDA-approved drug or device exists for treating vascular dementia, that current options target symptoms rather than slowing progression, and that lifestyle and comorbid condition management are emphasized for prevention.
-
Dementia was significantly associated with caregiver burden related to emotional difficulty (odds ratio [OR] = 2.04; 95% confidence interval [CI], 1.34-3.09) and physical difficulty (OR = 1.67, 95% CI, 1.01-2.78), but not financial difficulty.
Why it matters
In this cross-sectional study, dementia was significantly associated with caregiver burden related to emotional difficulty and physical difficulty, but not financial difficulty. It clarifies factors linked to caregiver burden but provides no evidence on treating, curing or preventing Alzheimer's disease.
-
127 patients (67.7% males) participated.
Why it matters
Among 127 patients with dementia and very severe challenging behavior, about half could be discharged to regular dementia special care units, one in ten could not be discharged, and one-third died during their stay. The study describes patient characteristics and outcomes, and the authors note that future work should explore whether and how treatment is effective.
-
BackgroundDifferentiating neurodegenerative diseases can be difficult in the clinical setting.
Why it matters
Among patients with frontotemporal dementia syndromes with parkinsonism and Parkinson's disease, there was significant overlap in how many met each other's diagnostic criteria, and neuroimaging showed substantial heterogeneity. The authors conclude that more precise diagnostic criteria are needed, which is about diagnosis rather than treatment.
-
Over a median follow-up period of 10.44 years, 725 participants developed incident dementia.
Why it matters
In this cohort, people who ate a more diverse range of foods had a lower risk of developing dementia, and this link was seen in those under 65 and those with higher genetic risk scores. This suggests that eating a variety of foods may be a strategy to reduce dementia risk, though the study cannot prove cause and effect.
-
Key Points Disasters cause significant human suffering, and patients with kidney diseases are uniquely vulnerable.
Why it matters
This paper is about disaster risk reduction and management in kidney care, not about Alzheimer's disease. It provides no information relevant to treating, curing, or preventing Alzheimer's disease.
-
Bringing together global efforts to enhance the implementation of warnings in managing vulnerabilities, hazards, risks, and disasters is essential to saving lives and for long-term vulnerability reduction.
Why it matters
This article is about multi-hazard early warning systems under the Sendai Framework for Disaster Risk Reduction, not about Alzheimer's disease. It identifies gaps in implementing effective early warning systems and contains no dementia findings.
-
Family caregivers provide essential care and support for individuals living with dementia, yet their contributions and needs are often unrecognized within formal health care systems.
Why it matters
This study found that family caregivers' experiences aligned with trauma-informed care principles and identified 'Uncertainty' as a novel principle reflecting ongoing challenges from diagnosis to inadequate in-home supports. It highlights the importance of recognizing trauma induced by interactions with formal health care services.
-
From 356 participants, 104 were MCI-C, whereas 252 were MCI-NC.
Why it matters
Among people with mild cognitive impairment, those who progressed to dementia were more often female, older and more cognitively impaired, while higher physical activity was protective. The authors say the findings may help define strategies to prevent or slow progression, but the study was observational.
-
During a median follow-up of 13.8 years, 6554 (1.9%) cases of incident delirium were documented.
Why it matters
In this UK Biobank cohort, prefrail and frail individuals had higher delirium risk, and healthy sleep offset much of the increased risk linked to frailty. The findings concern delirium risk, not the treatment, cure or prevention of Alzheimer's disease.
-
The Inflation Reduction Act Medicare Part D benefit redesign will reduce OOP drug spending for beneficiaries with dementia, resulting in potentially marked savings not only for low-income beneficiaries and beneficiaries with a high comorbidity burden but also for higher-income beneficiaries.
Why it matters
This simulation projected that under the Inflation Reduction Act Medicare Part D redesign, average annual out-of-pocket drug expenditures among beneficiaries with dementia would fall from $56 to $25 for low-income subsidy beneficiaries and from $772 to $576 for non-low-income subsidy beneficiaries. It addresses drug cost sharing rather than treating, curing, or preventing Alzheimer's disease.
-
The findings of this study suggest that predictive modeling could inform patients and clinicians about ASCVD at risk for dementia.
Why it matters
In UK Biobank data from 29,561 patients with atherosclerotic cardiovascular disease, a machine learning model using clinical and sociodemographic variables predicted risk of incident dementia. The authors suggest this could inform patients and clinicians about risk, but it is a prediction tool, not a treatment, cure, or prevention.
-
Lifestyle factors and ambient air pollution are linked to dementia and CMDs, yet few studies have investigated their impact on dementia risk in CMDs patients at the same time.
Why it matters
In this UK Biobank analysis, high levels of ambient air pollution and unhealthy lifestyles were each linked to a higher risk of mild cognitive impairment and dementia in people with cardiometabolic diseases. The findings suggest that improving lifestyle may lessen the effect of air pollution on that risk, though the study does not test a treatment or cure.
-
Depression was a strong risk factor for incident dementia with an OR of 1.76 (95% CI 1.63 to 1.90), a relationship which was found to be specific to depression rather than commonly proposed confounders.
Why it matters
This study found depression was strongly linked to later dementia, but concludes the relationship is largely due to reverse causation, meaning brain changes from dementia may cause depression rather than the other way around, with a smaller causal component. This means treating depression is unlikely to be a major route to preventing dementia.
-
In total, 3028 posts were retrieved, including 1552 from older adult-related subreddits and 1476 from Alzheimer disease-related subreddits; 18 key topics were identified, with the most frequent topics being expressing feelings (2178/3028, 71.93%) and seeking advice and support (1982/3028, 65.46%).
Why it matters
This analysis of Reddit posts found that caregivers predominantly expressed negative emotions, with those in Alzheimer disease-related subreddits showing slightly greater fear and sadness. Posts from Alzheimer disease-related subreddits emphasized health- and medical-related topics and expressing feelings, while older adult-related posts focused more on practical caregiving issues and seeking advice.
-
Daily informal care time was 0.5 hours higher in moderate compared to mild and 1.3h higher in severe compared to mild cognitive impairment.
Why it matters
This study estimated daily informal care time for people with dementia in Europe, finding it was 0.5 hours higher in moderate and 1.3 hours higher in severe compared to mild cognitive impairment. The estimates are intended for health-economic modelling and do not test any treatment, cure or prevention for dementia.
-
Moreover, a theoretical model proposes that frontotemporal dementia manifestations result from a deficit in goal-directed behaviour, which may be related to altered dopamine control of the frontostriatal circuitry.
Why it matters
Using brain imaging, researchers found lower dopamine transporter levels in frontotemporal dementia compared to healthy controls, with a different distribution pattern than in Parkinson's disease. The authors suggest this pattern could serve as a biomarker, but this is a diagnostic finding, not a treatment.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Falls as a complication of diabetes mellitus in older people
- Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association
- Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison
- Targeting and managing behavioral symptoms in individuals with dementia: a randomized trial of a nonpharmacological intervention
- Tools Measuring Quality of Death, Dying, and Care, Completed after Death: Systematic Review of Psychometric Properties
- Advance care planning and quality of life: A qualitative interview study in people with young-onset dementia and their family caregivers
- Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)
- Frequency, risk factors, and prognosis of prolonged delirium in elderly patients after hip fracture surgery
- Neuropsychiatry of Huntington's disease and other basal ganglia disorders
- Effect of literacy on neuropsychological test performance in nondemented, education-matched elders