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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Cognitive tests and assessment

Reviewed as evidence on: BMI (overweight/obese) at dementia diagnosis and mortality after dementia diagnosis 4 studies (what the news said). Being listed means the study bears on the question, not that it agrees with the news.

Topic: Risk, prevention and care in population studies

224 subjects progressed to dementia (SCD=38 (9.72%), MCI=186 (50.8%)). On average, a dementia diagnosis was given 3.09 years (SD=1.95) after baseline. BAG predicted progression to dementia, with added value beyond VRS (Table 2). The predictive value of BAG was strongest in SCD, where VRS provided no added value. In MCI, the predictive value of BAG was lower and insignificant when VRS were included (Table 3). BAG is predictive of progression to dementia in SCD and MCI and has added value over VRS in SCD. This highlights the potential of BAG as a predictor of progression to dementia, especially in early disease stages, when traditional VRS are insensitive.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

de Vries, S., Farkas, K., ten Kate, M., Rhodius‐Meester, H. F. M., Trieu, C., Wink, A. M., et al. (2025). Brain Age Gap Predicts Progression to Dementia in SCD and MCI. Alzheimer s & Dementia. https://doi.org/10.1002/alz70856_103050

Vancouver

de Vries S, Farkas K, ten Kate M, Rhodius‐Meester HFM, Trieu C, Wink AM, et al. Brain Age Gap Predicts Progression to Dementia in SCD and MCI. Alzheimer s & Dementia. 2025. doi:10.1002/alz70856_103050. PMID: 41448625.

BibTeX

@article{devries2025-41448625,
  author  = {de Vries, Stefan and Farkas, Katalin and ten Kate, Mara and Rhodius‐Meester, Hanneke F. M. and Trieu, Calvin and Wink, Alle Meije and Lötjönen, Jyrki M. P. and van der Flier, Wiesje M. and others},
  title   = {{Brain Age Gap Predicts Progression to Dementia in SCD and MCI}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_103050},
  pmid    = {41448625},
  url     = {https://doi.org/10.1002/alz70856_103050}
}

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Key findings

224 subjects progressed to dementia (SCD=38 (9.72%), MCI=186 (50.8%)).
On average, a dementia diagnosis was given 3.09 years (SD=1.95) after baseline.
BAG predicted progression to dementia, with added value beyond VRS (Table 2).
The predictive value of BAG was strongest in SCD, where VRS provided no added value.
In MCI, the predictive value of BAG was lower and insignificant when VRS were included (Table 3).

Why it matters

In this study, brain age gap predicted progression to dementia in people with subjective cognitive decline and mild cognitive impairment. Its predictive value was strongest in subjective cognitive decline, where vascular risk scores provided no added value.

Study details

Participants391
Effect size9.72%; 50.8%
Evidence strengthModerate

How this study scored 45/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	391 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Bas Jasperse: h-index 21 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41448625)
Free to read	2 / 2	Free to read
Total	45 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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