Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,032 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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Subtype and Stage Inference (SuStaIn) is an unsupervised learning algorithm that uniquely enables the identification of subgroups of individuals with distinct pseudo-temporal disease progression patterns from cross-sectional datasets.
Why it matters
This study describes a new version of a computer method that can find subgroups of patients with different disease progression patterns using ordinal data like clinical scores and visual ratings. This expands the types of data that can be used to study how diseases like Alzheimer's progress, but it is a methodological tool rather than a treatment or cure.
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A thematic analysis revealed factors that motivate household members to use these technologies.
Why it matters
This work used a user-centered design approach to identify the needs of patients, caregivers and clinicians and the challenges of using remote monitoring systems in dementia care. It is about designing monitoring technology, not about treating, curing or preventing Alzheimer's disease.
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Divorced marital status was significantly associated with an increased LOS following TKA.
Why it matters
This study looked at social factors linked to cost and length of stay after knee replacement surgery. It does not address treating, curing, or preventing Alzheimer's disease.
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This review should serve as a compendium of updated information on VaD and provide guidance in terms of newer diagnostic and potential therapeutic approaches.
Why it matters
This review describes vascular dementia as the second most common cause of dementia, caused by ischemic or hemorrhagic brain injury, and discusses diagnosis and treatment approaches. It is about vascular dementia, a different condition from Alzheimer's disease.
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The INTε4+ group did not seem markedly more responsive to the guidance than the other groups.
Why it matters
In 188 healthy Finnish volunteers, lifestyle guidance produced small beneficial changes, and those told they carried the APOE ε4 allele were not clearly more responsive. This concerns lifestyle motivation, not treating, curing or preventing Alzheimer's disease.
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Since the initial reports of coronavirus disease 2019 (COVID-19) in China in late 2019, infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have spread rapidly, resulting in a global pandemic that has caused millions of deaths.
Why it matters
This paper discusses long-term respiratory and neurological sequelae of COVID-19, noting that these are increasingly recognized and concerning. It does not study Alzheimer's disease treatment, cure, or prevention.
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Persons with dementia are at high risk for loss of decision-making ability due to increased cognitive decline as the disease progresses.
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Understanding the relationship between infection and stroke has taken on new urgency in the era of the coronavirus disease 2019 (COVID-19) pandemic.
Why it matters
This review describes how infection can trigger stroke and how stroke can suppress the immune system and increase infection risk. It notes emerging evidence that post-stroke immune changes may worsen long-term cognitive outcomes and increase the risk of post-stroke neurodegeneration and dementia.
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Delirium is a debilitating form of brain dysfunction frequently encountered in the intensive care unit (ICU).
Why it matters
This review states that delirium in the intensive care unit is linked to cognitive impairment that persists long after hospital discharge, and that nonpharmacologic management using the ABCDEF bundle remains the cornerstone of care. It does not report a treatment that cures or prevents Alzheimer's disease.
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The present work contributes to the literature on ICT usability needs of users with MCI.
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48/100
Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID-19, if sufficient resources are available.
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Economics and mental health are intertwined.
Why it matters
This review discusses how economic evaluation can inform mental health policy and notes that clearer evidence exists for cognitive stimulation and multicomponent carer interventions for dementia. It is about costs and policy, not about curing or preventing Alzheimer's disease.
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New personalized endpoints that are clinically meaningful to individuals and their families should be developed.
Why it matters
A 2018 Association for Frontotemporal Degeneration meeting report naming two main obstacles to drug trials in frontotemporal lobar degeneration (FTLD): the condition varies so much between patients that treatment effects are hard to measure, and it is rare enough that recruitment is hard. It calls for endpoints that are meaningful to patients and families, and suggests personalised MRI analysis, new fluid biomarkers and wearable devices to make trials more sensitive. These are proposals, not tested results, and the report is about FTLD trial methods, not Alzheimer's treatment.
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We analyzed the frequency of cognitive impairment (CI) in deceased COVID-19 patients at a tertiary hospital in Spain.
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These results suggest pairing tDCS with cognitive training enhances functional connectivity and working memory performance in older adults, and thus may hold promise as a method for remediating age-related cognitive decline.
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Higher phosphatidylcholine intake was associated with lower risk of incident dementia and better cognitive performance in men in eastern Finland.
Why it matters
In this observational study of middle-aged and older men, those with the highest phosphatidylcholine intake had a 28% lower risk of dementia than those with the lowest intake. Because it is an observational study, it cannot prove that eating more choline prevents dementia.
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Older adults with mild dementia demonstrated worse baseline cognitive performance than participants without dementia.
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Noncommunicable disease now contributes to the World Health Organization top 10 causes of death in low-, middle- and high-income countries.
Why it matters
Risk factors such as smoking, physical inactivity, obesity, and hypertension are confirmed to increase the risk of noncommunicable diseases including dementia. Targeting these shared risk factors could potentially reduce the impact on multiple diseases at once, though more work is needed to measure these relationships.
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Early and accurate diagnosis of MCI provides a window of opportunity to improve the outcomes using a multimodal management approach including lifestyle risk factor modification and consideration of the multinutrient Souvenaid.
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48/100
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly.
Why it matters
This review notes growing evidence linking age-related hearing loss to cognitive decline and increased dementia risk, and describes hearing loss as a potentially modifiable risk factor. It states that understanding of the underlying molecular mechanisms is very limited and that therapeutic interventions are urgently needed but not yet established.
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Along with rapid global population aging, the age-related cognitive disorders such as mild cognitive impairment (MCI) and dementia have posed a serious threat to public health, health care system, and sustainable economic and societal development of all countries.
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Mild cognitive impairment (MCI) is the preliminary stage of dementia, which may lead to Alzheimer's disease (AD) in the elderly people.
Why it matters
A single-channel EEG method detected mild cognitive impairment with 87.9% accuracy using speech-evoked brain responses in 23 subjects. This is an early detection approach, not a treatment, cure or prevention for Alzheimer's disease.
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Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems.
Why it matters
This review notes that chronic pain is common in older adults and that its drug treatment is usually only partially effective and limited by side effects. It also points out that chronic pain is a risk factor for accelerated cognitive decline, suggesting possible shared mechanisms with dementia, and that more research is needed.
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48/100
Older adults with sensory and cognitive impairments constitute a particularly prevalent and vulnerable population who are at increased risk of hospitalization and contribute to higher healthcare spending.
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Algorithmic diagnoses provide a cost-effective way to conduct dementia research.
Why it matters
This study compared five methods for identifying dementia from existing Health and Retirement Study data rather than diagnosing it in person. The methods varied widely in sensitivity, so these algorithms are tools for estimating dementia rates in research, not for treating or preventing the disease.
From across this topic
10 of the 7,981 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Dying with dementia in long-term care
- Association of medication adherence quality measures for diabetes, hypertension, and hyperlipidemia with cognitive decline
- Intrusions and perseverations
- Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia
- The relative contributions of MRI, SPECT, and PET imaging in epilepsy
- Revisiting the Montreal Cognitive Assessment in a European cohort of elderly living with type 2 diabetes
- Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies
- Neuroprotective action of resveratrol
- Quality of dying in nursing home residents dying with dementia: does advanced care planning matter? A nationwide postmortem study
- The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods