Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Twenty-nine articles met our inclusion criteria and were categorized into 3 groups as follows: (a) mobile versions of existing article or computerized neuropsychological tests; (b) new cognitive tests developed specifically for mobile platforms; and (c) the use of new types of data for cognitive assessment.
Why it matters
This review found 29 studies using smartphones and tablets for cognitive assessment of older adults, covering mobile versions of existing tests, new mobile-specific tests, and new types of data. It confirms potential for mobile assessment but does not show that these tools treat, cure, or prevent Alzheimer's disease.
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Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking or speech problems.
Why it matters
This review proposes that dysfunction of cerebrovascular endothelial cells occurs before vascular dementia and suggests eNOS/NO, RhoA, and caveolin-1 as targets for new drugs. These are proposed targets only, not tested treatments, and the focus is vascular dementia rather than Alzheimer's disease.
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The quality of dying and quality of end-of-life care in nursing homes in the countries studied are not optimal.
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499 adults 48 to 91 years-old enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and were administered the MoCA during baseline.
Why it matters
This study tested whether adjusting Montreal Cognitive Assessment scores for education and other norms improves screening for mild cognitive impairment and Alzheimer's dementia in 499 adults. It addresses how memory screening is scored, not how Alzheimer's is treated, cured, or prevented.
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Key mechanisms of action were: improved observation and awareness of residents, collaborative assessment, comprehensive 'picture of the person', systematic record keeping, improved review and monitoring, care planning and changes to care provision, and facilitated multi-agency communication.
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It was demonstrated that prevalence of polypharmacy, PIM, and PPO could be decreased by CGA including START/STOPP criteria in older adults.
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Of 15,390 narratives collected from 3139 patients with PsA for exploratory analysis, physical concepts were the most common (81.5%), followed by emotional (50.7%), cognitive (20.0%), role activity (8.1%), and social (5.6%) concepts.
Why it matters
This study analyzed online narratives from patients with psoriatic arthritis and found cognitive issues were discussed but not captured by standard questionnaires. It concerns psoriatic arthritis, not Alzheimer's disease, so it has no direct implications for treating, curing or preventing dementia.
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The changing dynamics over a 20-year period of this palliative care programme in Kerala, India, highlights the need for similar programmes to remain flexible and adapt their services in response to a growing global burden of Non Communicable Diseases.
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Numerous epidemiological studies have strongly suggested that multinutrient approaches using the Mediterranean diet (Med diet), dietary approach to systolic hypertension (DASH) and the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) are associated with a lower risk of cognitive impairment, MCI and Alzheimer's disease in older persons.
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People with advanced dementia in their final phase of life have a multitude of individual and complex needs.
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45/100
We have a poor understanding of whether dementia clusters geographically, how this occurs, and how dementia may relate to socio-demographic factors.
Why it matters
Using general practice records in west Adelaide, this study found clusters of higher dementia risk in some areas and lower risk in others, with hotspots in low socioeconomic communities. It identifies where risk clusters occur but does not test any treatment or prevention.
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The findings identify resident subgroups at especially high risk of poor oral health who can be targeted in quality improvement efforts related to oral hygiene; they also indicate need to improve the accuracy of how MDS items are completed.
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Timeliness and consistency of relationship is crucial to building rapport and trust in the service's ability to help at post-bereavement as well as a focus on the specific rather than the generic needs of the bereaved.
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Discussions revealed that people were generally supportive of this type of research, provided they gave informed consent and that devices were discreet, comfortable and easy to use.
Why it matters
This study involved people affected by dementia in discussions about connected health wearables research and found they were generally supportive if devices were discreet, comfortable, and easy to use. It does not test any treatment, cure, or prevention for Alzheimer's disease, and it shows it is feasible to involve people affected by dementia in shaping research tools.
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It is true that a primary goal of diabetes early diagnosis and treatment is quality of life (QoL).
Why it matters
This review discusses quality of life in type 2 diabetes and notes that studies performed so far have shown little to moderate benefit. It does not report any treatment, cure, or prevention for Alzheimer's disease.
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Exercise training is an effective means for promoting white matter and hippocampal recovery and improving reaction time in children treated with cranial radiation for brain tumors.
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Incident stroke has long been recognized to cause dementia shortly after the event.
Why it matters
This review notes that clinical trials to prevent delayed-onset poststroke dementia over the past 10 to 15 years have been disappointing, and that delayed-onset cases are associated mainly with severe sporadic small vessel disease. It proposes future research directions rather than reporting an effective prevention.
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Type 2 diabetes mellitus (T2D) and Alzheimer's disease (AD) are two of the most common diseases of aging around the world.
Why it matters
This review discusses how type 2 diabetes may increase the risk of Alzheimer's disease and is associated with progressive cognitive decline, with impaired insulin signalling, inflammation, advanced glycation end-products and oxidative stress proposed as shared pathways. It is a perspective piece and does not report any tested prevention or treatment for dementia.
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Cognitively normal subjects with an APOE ε4 allele had a higher likelihood of developing aMCI and the MCI subtype was associated with the dementia subtype.
Why it matters
Cognitively normal people with one or two copies of the APOE ε4 allele were more likely to develop amnestic mild cognitive impairment. Multiple-domain amnestic mild cognitive impairment patients were more likely to progress to dementia than single-domain patients.
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Hospice offers holistic support for individuals living with terminal illness and their caregivers.
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The findings from this study add to the anatomical knowledge of hippocampal subregions in PD, allowing us to understand the unique functional contribution of each subfield.
Why it matters
In 65 people with Parkinson's disease followed for 18 months, atrophy in specific hippocampal subfields was linked to conversion from no cognitive impairment to mild cognitive impairment. This concerns Parkinson's disease-related cognitive decline and does not test any treatment.
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The hippocampus is one of the most well studied structures in the human brain.
Why it matters
This paper notes that the link between normal cognitive aging and hippocampal structure is still poorly studied, with contradictory results so far. It is background on brain aging without disease and offers no treatment, cure or prevention.
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Integrated Palliative care Outcome Scale for Dementia is a comprehensive and acceptable caregiver-reported measure to detect symptoms and problems in dementia.
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The associations of an active lifestyle with cognitive change over time in a dementia risk group were stronger than the effects of short-term, specific training interventions.
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An influential review in 2010 concluded that non-pharmacological multi-component interventions have positive effects on cognitive functioning, activities of daily living, behaviour and mood of people with dementia.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Herpes Zoster Vaccination and Dementia Occurrence (Australian natural experiment)
- Neuroinflammation in dementia: A meta-analysis of PET imaging studies
- Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program
- Cognitive Flexibility Training: A Large-Scale Multimodal Adaptive Active-Control Intervention Study in Healthy Older Adults
- Health Care Costs of Alzheimer’s and Related Dementias Within a Medicare Managed Care Provider
- Continued Use of Cholinesterase Inhibitors and Memantine in Hospice
- Atrial fibrillation and stroke prevention with warfarin in the long-term care setting
- Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
- Does Cognitive Training Prevent Cognitive Decline?: A Systematic Review
- Race and Ethnicity, Lifestyle, Diet, and Survival in Patients With Prostate Cancer