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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,076–24,100 of 27,380 studies, newest first · page 964 of 1096.

June 2004 23

  1. 2004-06-01

    The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

    ✓ Peer-reviewed Drug development European journal of biochemistry

    Key finding: Although the ADAM10 ASO and TACE ASO significantly reduced (> 81%) their respective mRNA levels and reduced the alpha-secretase shedding of APP by 60% and 30%, respectively, neither ASO reduced the shedding of ACE. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2004-06-01

    Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

    ✓ Peer-reviewed Drug development Biochemistry

    Key finding: (2000) 351, 95-105) suggests novel benefits of this drug in addition to mood stabilization. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-06-01

    Hippocampal volume change in depression: late- and early-onset illness compared

    ✓ Peer-reviewed Hippocampus size on brain scans The British journal of psychiatry : the journal of mental science

    Key finding: Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-06-01

    Estimating prognosis for nursing home residents with advanced dementia

    ✓ Peer-reviewed End-of-life care JAMA

    Key finding: A risk score based on 12 variables from the MDS estimates 6-month mortality for nursing home residents with advanced dementia with greater accuracy than existing prognostic guidelines. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-06-01

    The association between delirium and cognitive decline: a review of the empirical literature

    ✓ Peer-reviewed Clinical safety Neuropsychology review

    Key finding: Delirium is a common neurobehavioral syndrome that occurs across health care settings which is associated with adverse outcomes, including death. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2004-06-01

    The blood-brain barrier: an overview: structure, regulation, and clinical implications

    ✓ Peer-reviewed Inflammation and the immune system Neurobiology of disease

    Key finding: Three cellular elements of the brain microvasculature compose the BBB-endothelial cells, astrocyte end-feet, and pericytes (PCs). +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-06-01

    Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies

    ✓ Peer-reviewed Brain tissue and pathology Archives of neurology

    Key finding: At autopsy the striatal dopaminergic transporter is reduced. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2004-06-01

    An active and socially integrated lifestyle in late life might protect against dementia

    ✓ Peer-reviewed Brain tissue and pathology The Lancet. Neurology

    Key finding: This review systematically analyses the published longitudinal studies exploring the effect of social network, physical leisure, and non-physical activity on cognition and dementia and then summarises the current evidence taking into account the limitations of the studies and the biological plausibility. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2004-06-01

    Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice

    ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology

    Key finding: However, studies on synaptic dysfunction in different transgenic AD models that overexpress familial AD mutant forms of amyloid precursor protein (APP) and/or presenilin (PS) have provided conflicting results. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2004-06-01

    Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease

    ✓ Peer-reviewed Mild cognitive impairment Journal of neuropathology and experimental neurology

    Key finding: We found that proNGF increased during the prodromal stage of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2004-06-01

    Influence of the amyloid precursor protein locus on dementia in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

    Key finding: APP is an important locus predicting the age at onset of dementia in people with Down syndrome.

    Full summary, score breakdown and related studies → Original source

  12. 2004-06-01

    Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine

    ✓ Peer-reviewed Down syndrome and Alzheimer's Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

    Key finding: This indicates that AGE may play an important role in Alzheimer disease (AD) by oxidation of tau. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2004-06-01

    Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study

    ✓ Peer-reviewed How common it is JAMA

    Key finding: For women aged 65 years or older, hormone therapy had an adverse effect on cognition, which was greater among women with lower cognitive function at initiation of treatment.

    Full summary, score breakdown and related studies → Original source

  14. 2004-06-01

    Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study

    ✓ Peer-reviewed How common it is JAMA

    Key finding: In the estrogen-alone trial, 47 participants were diagnosed with probable dementia, of whom 28 were assigned to CEE and 19 to placebo (hazard ratio [HR], 1.49; 95% confidence interval [CI], 0.83-2.66). +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2004-06-01

    The importance of neuritic plaques and tangles to the development and evolution of AD

    ✓ Peer-reviewed Disparities Neurology

    Key finding: Deterioration in Alzheimer disease appears to be driven by neuritic plaques and neurofibrillary tangles at different stages of the disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2004-06-01

    The nature and determinants of neuropsychological functioning in late-life depression

    ✓ Peer-reviewed Caregiving Archives of general psychiatry

    Key finding: Late-life depression is characterized by slowed information processing, which affects all realms of cognition. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2004-06-01

    Preserved neural correlates of priming in old age and dementia

    ✓ Peer-reviewed Brain scans and imaging Neuron

    Key finding: These results suggest that despite difficulties with deliberate memory, both older adults without dementia and those with early-stage DAT can modify behavior mediated by prefrontal contributions, making these preserved abilities an attractive target for cognitive training and rehabilitation.

    Full summary, score breakdown and related studies → Original source

  18. 2004-06-01

    APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42

    ✓ Peer-reviewed Genetics Neurology

    Key finding: By analysis of a large cohort of AD patients (n = 563) and control subjects (n = 118), it is shown that the epsilon4 allele is strongly associated with reduced CSF levels of beta-amyloid (1-42) (Abeta42) in both AD (p < 10(-9)) and control (p = 0.0012) populations.

    Full summary, score breakdown and related studies → Original source

  19. 2004-06-01

    Apolipoprotein E controls the risk and age at onset of Parkinson disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2004-06-01

    APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Unlike Alzheimer disease, for which the APOE-epsilon4 allele increases the prevalence and the APOE-epsilon2 allele is protective, the authors' analysis shows the APOE-epsilon2 allele, but not the APOE-epsilon4 allele, to be positively associated with sporadic Parkinson disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2004-06-01

    Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: The epsilon4 allele does not predict cholinergic decline in AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2004-06-01

    Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Memory declined in APOE e4 carriers before the symptomatic presentation of MCI in a cohort whose mean age was 60 years over a median period of 33 months.

    Full summary, score breakdown and related studies → Original source

  23. 2004-06-01

    The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism

    ✓ Peer-reviewed Genetics Annals of the New York Academy of Sciences

    Key finding: Epidemiologic studies indicate that elderly women are at higher risk for Alzheimer disease compared to men. +2 more findings

    Full summary, score breakdown and related studies → Original source

May 2004 2

  1. 2004-05-24

    Axonal mitochondrial transport and potential are correlated

    ✓ Peer-reviewed Disease mechanisms Journal of Cell Science

    Key finding: Analysis of fast axonal transport showed that the uniform distribution arose from the clustering of the stopping events of fast axonal transport in the middle of the gaps between stationary mitochondria. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2004-05-24

    Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study

    ✓ Peer-reviewed Brain scans and imaging Hypertension (Dallas, Tex. : 1979)

    Key finding: The risk (OR, 95% CI) was estimated for HA associated with systolic ( or =140 mm Hg) and diastolic ( or =90 mm Hg) BP and with antihypertensive treatment. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →