Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,576–24,600 of 27,380 studies, newest first · page 984 of 1096.
February 2003 23
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2003-02-10
Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
36/100 ✓ Peer-reviewed Vascular contributions Proceedings of the National Academy of Sciences of the United States of America
Key finding: Impaired glutamate transport induces neurotoxicity associated with numerous pathological processes, including stroke/ischemia, temporal lobe epilepsy, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, HIV-1-associated dementia, and growth of malignant gliomas. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-02-01
Dietary Fats and the Risk of Incident Alzheimer Disease
45/100 ✓ Peer-reviewed Risk factors Archives of Neurology
Key finding: After a mean follow-up of 3.9 years, 131 persons developed Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Behavioural brain research
Key finding: Further, BDNF levels were negatively correlated with working memory errors during the latter portion of testing in Ts65Dn mice, thereby suggesting that lower BDNF protein levels in the frontal cortex may be associated with the observed working memory impairment.
Full summary, score breakdown and related studies → Original source
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2003-02-01
Low blood pressure and risk of dementia in the Kungsholmen project: a 6-year follow-up study
50/100 ✓ Peer-reviewed Drug development Archives of neurology
Key finding: Both low diastolic and high systolic pressure are associated with an increased risk of Alzheimer disease and dementia in this elderly population. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Alzheimer's disease and angiogenesis
41/100 ✓ Peer-reviewed Drug development Lancet (London, England)
Key finding: Despite enormous investigative efforts, the pathological basis for Alzheimer's disease remains unclear.
Full summary, score breakdown and related studies → Original source
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2003-02-01
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils
40/100 ✓ Peer-reviewed Drug development Molecular psychiatry
Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is probably caused by the cytotoxic effect of the amyloid beta-peptide (Abeta). +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-02-01
beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
36/100 ✓ Peer-reviewed Treatments Biochemical pharmacology
Key finding: The increasing beta-conformation content induced by HuAChE, preliminary to the formation of Abeta fibrils, was determined by circular dichroism. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Homocysteine, white matter hyperintensities, and cognition in healthy elderly people
60/100 ✓ Peer-reviewed Vascular contributions Annals of neurology
Key finding: Hyperhomocysteinemia is associated with an increased risk of vascular disease, and recent results suggest that it also could increase the risk of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
The utilization of physical therapy in a palliative care unit
45/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: PT assessment and utilization were uncommon in this group. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Dynamics of Gray Matter Loss in Alzheimer's Disease
56/100 ✓ Peer-reviewed Brain scans and imaging Journal of Neuroscience
We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2003-02-01
Neuroimaging and early diagnosis of Alzheimer disease: a look to the future
48/100 ✓ Peer-reviewed Brain tissue and pathology Radiology
Key finding: Current consensus statements have emphasized the need for early recognition and the fact that a diagnosis of AD can be made with high accuracy by using clinical, neuropsychologic, and imaging assessments. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial
61/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of clinical pharmacy and therapeutics
Key finding: Alzheimer's disease is characterized by a slow, progressive decline in cognitive function and behaviour. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44
46/100 ✓ Peer-reviewed TREM2 and immune genetics European journal of immunology
Key finding: In addition to triggering receptor expressed on myeloid cells (TREM)-1 and TREM2, the cluster contains NKp44, a triggering receptor whose expression is limited to NK cells. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology
42/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD
Key finding: Several recent studies indicate that activity of cholinergic enzymes in the cortex of people with mild cognitive impairment (MCI) and early Alzheimer's disease (AD) are preserved. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging
59/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: MCI refers to patients with significant but isolated memory impairment relative to subjects of identical age. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurocytology
Key finding: Furthermore, in AD and DS brains ADAM 10 immunoreactivity was associated with diffuse and neuritic plaques. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Prevalence of dementia in older latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors
59/100 ✓ Peer-reviewed How common it is Journal of the American Geriatrics Society
Key finding: Overall dementia prevalence was 4.8%. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Vascular cognitive impairment
58/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology
Key finding: Here we review the current state of scientific knowledge on the subject of vascular brain burden. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia
68/100 ✓ Peer-reviewed Getting a diagnosis The Journal of clinical psychiatry
Key finding: The trial was completed by 67% of patients in the placebo group and 73% of patients in the risperidone group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
55/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: The current study suggests that lower Abeta 42 levels reflect neuropathologic processes implicated in amyloid-related pathologies, such as NP and CAA. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study
53/100 ✓ Peer-reviewed Getting a diagnosis International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
Key finding: The adverse effects of obesity and hypertension in men are independent and cumulative with respect to cognitive deficit.
Full summary, score breakdown and related studies → Original source
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2003-02-01
Antioxidant vitamin intake and risk of Alzheimer disease
47/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Neither dietary, supplemental, nor total intake of carotenes and vitamins C and E was associated with a decreased risk of AD in this study. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-02-01
Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status
57/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Apolipoprotein E epsilon4 led to increased risk of AD among white subjects but not black subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
January 2003 2
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2003-01-28
Early onset familial Alzheimer's disease: Mutation frequency in 31 families
41/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology
Key finding: The mean AAO was 46.9 years (median 45 years; range 33 to 60 years). +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-01-24
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: Measurements taken at age 100 days, before Abeta deposition, revealed a 12.3% reduction of hippocampus volume in Tg mice compared with WT controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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