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Total tau in cerebrospinal fluid differentiates Alzheimer's disease from vascular dementia
Leszek J, Małyszczak K, Janicka B, Kiejna A, Wiak A.. Medical science monitor : international medical journal of experimental and clinical research, 2003-11-01
Topic: Amyloid, tau and blood-test diagnosis
Background Tau protein is a microtubule-associated protein located in neuronal axons, which has been used in various configurations as a diagnostic marker of degenerative changes in the CNS. The aim of our study was to evaluate the use of CSF/ total tau in patients with Alzheimer-type dementia (AD) and vascular dementia (VD) compared to controls, in order to investigate. Material/methods A total of 102 persons were included in the study: 58 AD patients, 24 VD patients, and 20 non-demented controls.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Leszek, J., Małyszczak, K., Janicka, B., Kiejna, A., & Wiak, A. (2003). Total tau in cerebrospinal fluid differentiates Alzheimer's disease from vascular dementia. Medical science monitor : international medical journal of experimental and clinical research.
Vancouver
Leszek J, Małyszczak K, Janicka B, Kiejna A, Wiak A. Total tau in cerebrospinal fluid differentiates Alzheimer's disease from vascular dementia. Medical science monitor : international medical journal of experimental and clinical research. 2003. PMID: 14586274.
BibTeX
@article{leszek2003-14586274,
author = {Leszek, J. and Małyszczak, K. and Janicka, B. and Kiejna, A. and Wiak, A.},
title = {{Total tau in cerebrospinal fluid differentiates Alzheimer's disease from vascular dementia}},
journal = {Medical science monitor : international medical journal of experimental and clinical research},
year = {2003},
pmid = {14586274}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The aim of our study was to evaluate the use of CSF/ total tau in patients with Alzheimer-type dementia (AD) and vascular dementia (VD) compared to controls, in order to investigate.
- Material/methods A total of 102 persons were included in the study: 58 AD patients, 24 VD patients, and 20 non-demented controls.
- The Alzheimer group was divided into 3 subgroups by clinical stage of the disease.
- CSF samples were collected by routine lumbar puncture.
Why it matters
This study evaluated cerebrospinal fluid total tau to tell Alzheimer-type dementia apart from vascular dementia and controls. It is a diagnostic comparison, so it does not provide a treatment, cure or prevention.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants102
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record and senior author's track record, so those were left out: it earned 32 of the 92 points we could judge it on, which is 35 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medical science monitor : international medical journal of experimental and clinical research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2003 — older than 20 years, still counted |
| Sample size | 2 / 4 | 102 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 25 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 25 year(s) since 2003 |
| Impact for its field and year | 1 / 6 | Cited 0.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Andrzej Wiak holds only 2 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 0 / 3 | Wroclaw Medical University: institution h-index 348 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 14586274) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 32 / 92 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 32 of the 92 points we could judge it on is 35 out of 100. |
| Total | 35 / 100 | — |
What each of these 20 components measures, and what this score is not →
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