Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,076–23,100 of 27,380 studies, newest first · page 924 of 1096.
July 2006 12
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2006-07-01
Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease
50/100 ✓ Peer-reviewed Mild cognitive impairment Clinical therapeutics
Key finding: MCI involves more substantial cognitive and memory decline than normal aging and represents a significant risk factor for the development of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy
50/100 ✓ Peer-reviewed Lewy body dementia Journal of neuropathology and experimental neurology
Key finding: The burden of alpha-synuclein pathology in brainstem nuclei, amygdala, and neocortex was significant lower in AD/ALB than in AD/LBD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-07-01
99mTc-HMPAO brain perfusion single-photon emission computed tomography in children with Down syndrome: relationship to epilepsy, thyroid functions, and congenital heart disease
26/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of child neurology
Key finding: As a result, the problems of these patients, such as thyroid diseases, leukemia, and Alzheimer disease, would be encountered more frequently. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
Telemedicine, dementia and Down syndrome: implications for Alzheimer disease
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This study supports the need for formal reliability and validity studies of TM preparatory to the consideration of this modality for use in clinical trials for AD.
Full summary, score breakdown and related studies → Original source
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2006-07-01
Elevated cortical zinc in Alzheimer disease
48/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Brain zinc accumulation is a prominent feature of advanced Alzheimer disease (AD) and is biochemically linked to brain amyloid beta-peptide accumulation and dementia severity in AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study
54/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: 20 (45%) patients developed a neurological disorder after a mean of 11.5 years from the reported onset of RBD and a mean follow-up of 5.1 years from the diagnosis of idiopathic RBD at our sleep centre. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
Alzheimer's disease
61/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)
Key finding: However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
Finding potent drugs for Alzheimer's disease is more important than proving the drugs are disease modifying
38/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Several designs that might prove DM have been proposed, including randomized start, randomized withdrawal, and slope analysis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
Prevention of Alzheimer disease
41/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: Two types of primary prevention trials have been conducted in AD to date: trials in independent cohorts specifically recruited for an AD primary prevention trial and cohorts in other studies randomized to a drug of interest where appropriate cognitive measures can be added. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
47/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: These CSF A beta 42 findings are consistent with acceleration by the APOE*4 allele of pathogenic A beta 42 brain deposition starting in later middle age in persons with normal cognition. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-07-01
Conversion to dementia from mild cognitive disorder: the Cache County Study
55/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Individuals with all types of mild cognitive impairment have an elevated risk of dementia over 3 years, more so in those with an APOE epsilon4 allele. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-07-01
In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system
32/100 ✓ Peer-reviewed Biomarkers Neurological research
Key finding: Features of multipotentiality of engineered NSC-derived cell lines versus naive cells (control-NSC) were assessed by immunocytochemical analysis in differentiation conditions. +4 more findings
Full summary, score breakdown and related studies → Original source
June 2006 13
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2006-06-30
Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison
40/100 ✓ Peer-reviewed Vascular contributions Brain : a journal of neurology
Key finding: Different neuropsychological populations implicate diverse cortical regions in semantic memory: semantic dementia (SD) is characterized by atrophy of the anterior temporal lobes whilst poor comprehension in stroke aphasia is associated with prefrontal or temporal-parietal infarcts. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-30
Cognitive decline correlates with neuropathological stage in Parkinson's disease
48/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the neurological sciences
Key finding: None of the patients had received the clinical diagnosis of dementia with Lewy bodies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-30
Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
45/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease
Key finding: We found no indications for altered dentate gyrus neurogenesis.
Full summary, score breakdown and related studies → Original source
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2006-06-28
Advance care planning and hospital in the nursing home
41/100 ✓ Peer-reviewed End-of-life care Age and ageing
Key finding: The intervention area consisted of two hospitals and the 21 nursing homes (NHs) around them compared with another, geographically separate, hospital and the 13 homes around it. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-28
Mitoenergetic failure in Alzheimer disease
36/100 ✓ Peer-reviewed Disease mechanisms American journal of physiology. Cell physiology
Key finding: Decreasing brain metabolism is a significant cause of cognitive abnormalities of Alzheimer disease (AD), but it remains uncertain whether this is the cause of further pathology or whether synaptic loss results in a lower energy demand. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-06-27
Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease
36/100 ✓ Peer-reviewed Prevention trials Biological psychiatry
Key finding: We conclude that structural and molecular prerequisites for activity-dependent plasticity are preserved in mutant mice with an AD-like pathology. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-06-27
The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
36/100 ✓ Peer-reviewed Drug development The Journal of biological chemistry
Key finding: We found that over-activation of Cdk5 in young transgenic animals does not induce tau hyperphosphorylation at sites recognized by the antibodies AT8, AT100, PHF-1, and TG3. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-27
The "posture second" strategy: a review of wrong priorities in Parkinson's disease
36/100 ✓ Peer-reviewed Clinical safety Journal of the neurological sciences
Key finding: The importance of mental dysfunction is supported by the fact that cognitive loading while walking or balancing can lead to marked deteriorations in postural performance, and there is some evidence to suggest that such "dual tasking" is particularly difficult for elderly persons with dementia or depression. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-26
Neuropsychological effects of bilateral STN stimulation in Parkinson disease
52/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Louis McDonnell Genome Institute; WGS, whole genome sequencing; WES, whole exome sequencing; indel, insertion-deletion variants; VCF, variant control format; MI, Mendelian inconsistency; MC, Mendelian consistency; GWAS, genome-wide association study; VR, referent allele read depth; DP, overall read depth; MS, mapping score; GQ, genotype quality score; Ti/Tv, Transition/Transversion; CS, concordance code
Full summary, score breakdown and related studies → Original source
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2006-06-26
Neuropathology of older persons without cognitive impairment from two community-based studies
64/100 ✓ Peer-reviewed Brain tissue and pathology Neurology
Key finding: Two (1.5%) persons met NIA-Reagan criteria for high likelihood AD, and 48 (35.8%) met criteria for intermediate likelihood; 29 (21.6%) had cerebral infarctions, and 18 (13.4%) had Lewy bodies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-25
Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
58/100 ✓ Peer-reviewed Risk genes beyond APOE Nature medicine
Key finding: In Alzheimer disease, accumulation of amyloid-beta (Abeta) in the brain and disease-causing mutations in amyloid precursor protein or in enzymes that produce Abeta indicate dysregulation of production or clearance of Abeta. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-23
Moving elderly inpatients to a transitional care facility reduced hospital stay but increased time to transfer to long term care
50/100 ✓ Peer-reviewed Health systems and care delivery Evidence-Based Nursing
Key finding: Crotty M, Whitehead CH, Wundke R, et al . +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-06-19
Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: The present study uses quantitative, high-resolution structural MRI techniques to investigate, in vivo, the anatomical substrate of memory dysfunction associated with MCI. +4 more findings
Full summary, score breakdown and related studies → Original source
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