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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,226–24,250 of 27,380 studies, newest first · page 970 of 1096.

February 2004 11

  1. 2004-02-01

    Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Neurology

    Key finding: A significant modification of these proteins and enzymes involved in the amyloid cascade was detected from the earliest clinically detectable disease stage. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2004-02-01

    Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway

    ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Neutralization of the acidic compartments leads to the accumulation of alpha-synuclein aggregates and exacerbates alpha-synuclein toxicity in postmitotic neuronal cells, suggesting that the accumulation of oligomeric intermediates may be an important event leading to alpha-synuclein-mediated cell death. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2004-02-01

    The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

    ✓ Peer-reviewed Lewy body dementia Annals of neurology

    Key finding: The postmortem examination showed atrophy of the substantia nigra, lack of Alzheimer pathology, and numerous Lewy bodies which were immunoreactive to alpha-synuclein and ubiquitin in cortical and subcortical areas. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-02-01

    Care arrangements for people with dementia in developing countries

    ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry

    Key finding: Older people in developing countries are indivisible from their younger family members. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2004-02-01

    Incidence and prevalence of dementia in the Cardiovascular Health Study

    ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

    Key finding: Classification resulted in 227 persons with prevalent dementia at entry into the study and 480 incident cases during follow-up. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-02-01

    Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: The association of neurofibrillary tangles with delayed verbal recall may reflect associated hippocampal atrophy. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2004-02-01

    Higher atrophy rate of entorhinal cortex than hippocampus in AD

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Twenty patients with AD and 25 CN subjects had MRI scans and clinical evaluations twice approximately 1.9 years apart.

    Full summary, score breakdown and related studies → Original source

  8. 2004-02-01

    Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: These data support the use of rates of change from serial MRI studies in addition to standard clinical/psychometric measures as surrogate markers of disease progression in AD.

    Full summary, score breakdown and related studies → Original source

  9. 2004-02-01

    The relationship between a dementia diagnosis, chronic illness, medicare expenditures, and hospital use

    ✓ Peer-reviewed Getting a diagnosis Journal of the American Geriatrics Society

    Key finding: Prevalence of dementia was 8.3%. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2004-02-01

    DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia

    ✓ Peer-reviewed Getting a diagnosis International journal of geriatric psychiatry

    Key finding: The DemTect is short (8-10 minutes), easy to administer, and its transformed total score (maximum 18) is independent of age and education. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2004-02-01

    The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial

    ✓ Peer-reviewed Treatments Archives of neurology

    Key finding: Cognitive decline over 36 months of continuous galantamine treatment was substantially less than the predicted cognitive decline of untreated patients with mild to moderate dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

January 2004 14

  1. 2004-01-29

    Hippocampal volume in early onset depression

    ✓ Peer-reviewed Hippocampus size on brain scans BMC medicine

    Key finding: Our findings provide new evidence of abnormalities in the hippocampus in early onset depression. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2004-01-28

    CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

    ✓ Peer-reviewed Brain tissue and pathology Human Molecular Genetics

    Key finding: Furthermore, 30-month-old mice overexpressing inducible Hsp70 show a significant reduction in tau levels.

    Full summary, score breakdown and related studies → Original source

  3. 2004-01-28

    Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls

    ✓ Peer-reviewed How common it is Brain : a journal of neurology

    Key finding: Reduced grey matter volume in PDD patients compared with controls was observed bilaterally in the temporal lobe, including the hippocampus and parahippocampal gyrus, and in the occipital lobe, the right frontal lobe and the left parietal lobe, as well as some subcortical regions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-01-27

    Free testosterone and risk for Alzheimer disease in older men

    ✓ Peer-reviewed Prevention and risk Neurology

    Key finding: Diagnosis of AD was associated inversely with FTI by itself and after adjustments for age, education, smoking status, body mass index, diabetes, any cancer diagnoses, and hormone supplements. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-01-21

    Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

    ✓ Peer-reviewed Brain scans and imaging Annals of Neurology

    Key finding: Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-01-20

    Awareness of deficits in mild cognitive impairment and Alzheimer's disease: do MCI patients have impaired insight?

    ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders

    Key finding: Very few studies have addressed this topic, and methodological inconsistencies make the comparison of previous studies difficult. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-01-15

    Framingham stroke risk profile and lowered cognitive performance

    ✓ Peer-reviewed Vascular contributions Stroke

    Key finding: In stroke- and dementia-free individuals, higher 10-year risk for stroke is associated with performance decrements in multiple cognitive domains. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2004-01-14

    β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

    ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

    Key finding: These findings suggest that the depolarization reflects oxidative damage to metabolic pathways upstream of mitochondrial respiration.

    Full summary, score breakdown and related studies → Original source

  9. 2004-01-13

    Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

    ✓ Peer-reviewed Genetics The Journal of biological chemistry

    Key finding: Furthermore, immunohistochemical studies show that prominent UCH-L1 immunostaining is associated with neurofibrillary tangles and that the level of soluble UCH-L1 protein is inversely proportional to the number of tangles in AD brains. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2004-01-12

    Heritability of leukoaraiosis in hypertensive sibships

    ✓ Peer-reviewed Disparities Hypertension (Dallas, Tex. : 1979)

    Key finding: The frequency distribution of the volume of leukoaraiosis was positively skewed, with a median value of 6.61 cm3 (interquartile range: 4.77 to 9 0.83 cm3). +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2004-01-06

    Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: In addition to APP, however, several other gamma-secretase substrates have been identified (e.g. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2004-01-01

    Frontotemporal Dementia: A Randomised, Controlled Trial with Trazodone

    ✓ Peer-reviewed Clinical trials Dementia and Geriatric Cognitive Disorders

    Key finding: The serotonergic system is associated with frontal lobes, the degeneration of which contributes to FTD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2004-01-01

    Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease

    ✓ Peer-reviewed Treatments International Journal of Geriatric Psychiatry

    Key finding: Patients on donepezil showed selective and significant (p<0.05) improvement on the memory subscale of the Dementia Rating Scale. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2004-01-01

    Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing

    ✓ Peer-reviewed Brain scans and imaging PubMed

    Key finding: Alpha-linolenic acid (18:3omega3) deficiency alters the structure and function of membranes and induces minor cerebral dysfunctions, as demonstrated in animal models and subsequently in human infants. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →