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Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease
Iracema Leroi, Jason Brandt, Stephen G. Reich, Constantine George Lyketsos, Stephen E. Grill, Richard E. Thompson, Laura Marsh. International Journal of Geriatric Psychiatry, 2004-01-01
Topic: Drug trials: efficacy and safety
Patients on donepezil showed selective and significant (p<0.05) improvement on the memory subscale of the Dementia Rating Scale. There was also a trend toward improvement on a measure of psychomotor speed and attention. There were no group differences in psychiatric status, motor function, or activities of daily living as measured at baseline or end-point. Adverse effects resulted in premature withdrawal of four patients on donepezil, two for peripheral cholinergic effects and one for increased parkinsonism. Side effects were associated with dosage increases. Donepezil has a beneficial effect on memory and may improve other cognitive deficits in patients with PD and cognitive impairment. However, variable tolerability in our sample underscores the need for careful monitoring when prescribing donepezil to patients with PD, especially with dosage increases.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Leroi, I., Brandt, J., Reich, S. G., Lyketsos, C. G., Grill, S. E., Thompson, R. E., et al. (2004). Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease. International Journal of Geriatric Psychiatry. https://doi.org/10.1002/gps.993
Vancouver
Leroi I, Brandt J, Reich SG, Lyketsos CG, Grill SE, Thompson RE, et al. Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease. International Journal of Geriatric Psychiatry. 2004. doi:10.1002/gps.993. PMID: 14716693.
BibTeX
@article{leroi2004-14716693,
author = {Leroi, Iracema and Brandt, Jason and Reich, Stephen G. and Lyketsos, Constantine George and Grill, Stephen E. and Thompson, Richard E. and Marsh, Laura},
title = {{Randomized placebo‐controlled trial of donepezil in cognitive impairment in Parkinson's disease}},
journal = {International Journal of Geriatric Psychiatry},
year = {2004},
doi = {10.1002/gps.993},
pmid = {14716693},
url = {https://doi.org/10.1002/gps.993}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Patients on donepezil showed selective and significant (p<0.05) improvement on the memory subscale of the Dementia Rating Scale.
- There was also a trend toward improvement on a measure of psychomotor speed and attention.
- There were no group differences in psychiatric status, motor function, or activities of daily living as measured at baseline or end-point.
- Adverse effects resulted in premature withdrawal of four patients on donepezil, two for peripheral cholinergic effects and one for increased parkinsonism.
- Side effects were associated with dosage increases.
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Study details
- Evidence strengthHigh
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 26 of the 58 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International Journal of Geriatric Psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 14716693) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 26 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 26 of the 58 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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