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Higher atrophy rate of entorhinal cortex than hippocampus in AD
Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, Miller BL, Reed BR et al.. Neurology, 2004-02-01
Topic: Brain proteins, microglia and lab models
Objectives To determine if atrophy rates were higher for entorhinal cortex (ERC) than for hippocampus in Alzheimer disease (AD), to determine the relationship between hippocampal atrophy rate and memory impairment, and to compare atrophy rates of ERC and hippocampus in differentiating between patients with AD and cognitively normal (CN) controls. Methods Twenty patients with AD and 25 CN subjects had MRI scans and clinical evaluations twice approximately 1.9 years apart. ERC volumes were measured manually and hippocampal volumes were measured semiautomatically on volumetric T1-weighted MR images. Results In AD, the atrophy rate of ERC (7.1 +/- 3.2%/year) was higher (p Conclusion The finding in AD that the atrophy rate in the entorhinal cortex is higher than in the hippocampus is consistent with the view that AD pathology begins in the entorhinal cortex.
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APA 7th
Du, A. T., Schuff, N., Kramer, J. H., Ganzer, S., Zhu, X. P., Jagust, W. J., et al. (2004). Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology. https://doi.org/10.1212/01.wnl.0000106462.72282.90
Vancouver
Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, et al. Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology. 2004. doi:10.1212/01.wnl.0000106462.72282.90. PMID: 14872024.
BibTeX
@article{du2004-14872024,
author = {Du, A. T. and Schuff, N. and Kramer, J. H. and Ganzer, S. and Zhu, X. P. and Jagust, W. J. and Miller, B. L. and Reed, B. R. and others},
title = {{Higher atrophy rate of entorhinal cortex than hippocampus in AD}},
journal = {Neurology},
year = {2004},
doi = {10.1212/01.wnl.0000106462.72282.90},
pmid = {14872024},
url = {https://doi.org/10.1212/01.wnl.0000106462.72282.90}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Results In AD, the atrophy rate of ERC (7.1 +/- 3.2%/year) was higher (p Conclusion The finding in AD that the atrophy rate in the entorhinal cortex is higher than in the hippocampus is consistent with the view that AD pathology begins in the entorhinal cortex.
Why it matters
In 20 patients with Alzheimer disease, the entorhinal cortex shrank faster per year than the hippocampus, consistent with the view that Alzheimer pathology begins in the entorhinal cortex. This is a small imaging study of brain atrophy rates and does not test any treatment, cure, or prevention.
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Study details
- Effect size3.2%
- Evidence strengthLow
How this study scored 53/100
Published in a leading specialty journal. Scored zero for study design, sample size, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 206 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.6 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 4 / 6 | Cited 8.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Michael Walter Weiner: h-index 171 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 14872024) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/01.wnl.0000106462.72282.90
- PubMed: 14872024
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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