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Insulin and neurodegenerative disease: shared and specific mechanisms
Craft S, Watson GS.. The Lancet. Neurology, 2004-03-01
Topic: Brain proteins, microglia and lab models
Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Craft, S., & Watson, G. S. (2004). Insulin and neurodegenerative disease: shared and specific mechanisms. The Lancet. Neurology. https://doi.org/10.1016/s1474-4422(04)00681-7
Vancouver
Craft S, Watson GS. Insulin and neurodegenerative disease: shared and specific mechanisms. The Lancet. Neurology. 2004. doi:10.1016/s1474-4422(04)00681-7. PMID: 14980532.
BibTeX
@article{craft2004-14980532,
author = {Craft, S. and Watson, G. S.},
title = {{Insulin and neurodegenerative disease: shared and specific mechanisms}},
journal = {The Lancet. Neurology},
year = {2004},
doi = {10.1016/s1474-4422(04)00681-7},
pmid = {14980532},
url = {https://doi.org/10.1016/s1474-4422(04)00681-7}
}
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Key findings
- We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.
Why it matters
This review summarizes research on insulin's influence on normal brain function and reviews evidence that perturbation of this role may contribute to symptoms and pathogenesis of neurodegenerative disorders including Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. The authors conclude by considering whether insulin dysregulation contributes to these disorders through disease-specific or general mechanisms.
Study details
- Evidence strengthLow
How this study scored 51/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet. Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 832 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 34.7 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 4 / 6 | Cited 17.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 21 other studies in this library |
| Still being cited | 3 / 4 | Cited 73 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author G. Stennis Watson: h-index 34 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 14980532) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
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