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Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide
Wu SZ, Bodles AM, Porter MM, Griffin WS, Basile AS, Barger SW.. Journal of neuroinflammation, 2004-04-20
Topic: Brain proteins, microglia and lab models
BACKGROUND: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid beta-peptide (Abeta), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the NMDA class of glutamate receptors, D-serine, could respond similarly.
Key findings
- Proinflammatory stimuli, including amyloid beta-peptide (Abeta), elicit a release of glutamate from microglia.
- We tested the possibility that a coagonist at the NMDA class of glutamate receptors, D-serine, could respond similarly.
- METHODS: Cultured microglial cells were exposed to Abeta.
- The culture medium was assayed for levels of D-serine by HPLC and for effects on calcium and survival on primary cultures of rat hippocampal neurons.
Why it matters
This laboratory study found that amyloid beta-peptide caused cultured microglia to release D-serine, a coagonist at NMDA glutamate receptors, and tested effects on rat hippocampal neurons. It is early cell-culture work and does not show any treatment, cure or prevention for Alzheimer's disease in people.
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroinflammation) |
| Journal's citation record | 2 / 4 | Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 187 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.8 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 3 / 6 | Cited 5.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Steven W. Barger: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Arkansas for Medical Sciences: institution h-index 591 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15285800) |
| Free to read | 2 / 2 | Free to read |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/1742-2094-1-2
- PubMed: 15285800
- Original source →
- Free full text: Journal of Neuroinflammation →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Wu, S. Z., Bodles, A. M., Porter, M. M., Griffin, W. S., Basile, A. S., & Barger, S. W. (2004). Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. Journal of neuroinflammation. https://doi.org/10.1186/1742-2094-1-2
Vancouver
Wu SZ, Bodles AM, Porter MM, Griffin WS, Basile AS, Barger SW. Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. Journal of neuroinflammation. 2004. doi:10.1186/1742-2094-1-2. PMID: 15285800.
BibTeX
@article{wu2004-15285800,
author = {Wu, S. Z. and Bodles, A. M. and Porter, M. M. and Griffin, W. S. and Basile, A. S. and Barger, S. W.},
title = {{Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide}},
journal = {Journal of neuroinflammation},
year = {2004},
doi = {10.1186/1742-2094-1-2},
pmid = {15285800},
url = {https://doi.org/10.1186/1742-2094-1-2}
}
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