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Hippocampal volume change in depression: late- and early-onset illness compared
Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT.. The British journal of psychiatry : the journal of mental science, 2004-06-01
Topic: Risk, prevention and care in population studies
Background Evidence for structural hippocampal change in depression is limited despite reports of neuronal damage due to hypercortisolaemia and vascular pathology. Aims To compare hippocampal and white matter structural change in demographically matched controls and participants with early-onset and late-onset depression. Method High-resolution volumetric magnetic resonance imaging (MRI) and rating of MRI hyperintensities. Results A total of 51 people with depression and 39 control participants were included. Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls. Hippocampal volumes did not differ between control participants and those with early-onset depression. Age of depression onset correlated (negatively) with hippocampal volume but lifetime duration of depression did not. Hyperintensity ratings did not differ between groups. Conclusions Results suggest that acquired biological factors are of greater importance in late-than in early-onset illness and that pathological processes other than exposure to hypercortisolaemia of depression underlie hippocampal atrophy in depression of late life.
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APA 7th
Lloyd, A. J., Ferrier, I. N., Barber, R., Gholkar, A., Young, A. H., & O'Brien, J. T. (2004). Hippocampal volume change in depression: late- and early-onset illness compared. The British journal of psychiatry : the journal of mental science. https://doi.org/10.1192/bjp.184.6.488
Vancouver
Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT. Hippocampal volume change in depression: late- and early-onset illness compared. The British journal of psychiatry : the journal of mental science. 2004. doi:10.1192/bjp.184.6.488. PMID: 15172942.
BibTeX
@article{lloyd2004-15172942,
author = {Lloyd, A. J. and Ferrier, I. N. and Barber, R. and Gholkar, A. and Young, A. H. and O'Brien, J. T.},
title = {{Hippocampal volume change in depression: late- and early-onset illness compared}},
journal = {The British journal of psychiatry : the journal of mental science},
year = {2004},
doi = {10.1192/bjp.184.6.488},
pmid = {15172942},
url = {https://doi.org/10.1192/bjp.184.6.488}
}
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Key findings
- Results A total of 51 people with depression and 39 control participants were included.
- Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls.
- Conclusions Results suggest that acquired biological factors are of greater importance in late-than in early-onset illness and that pathological processes other than exposure to hypercortisolaemia of depression underlie hippocampal atrophy in depression of late life.
Study details
- Participants51
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The British journal of psychiatry : the journal of mental science) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 1 / 4 | 51 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15172942) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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