Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,951–23,975 of 27,380 studies, newest first · page 959 of 1096.
October 2004 6
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2004-10-01
Detection and management of cognitive impairment in primary care: The Steel Valley Seniors Survey
58/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Physicians noted impairment in a minority of impaired patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-10-01
Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease
50/100 ✓ Peer-reviewed Disparities Neurology
Key finding: NIFID is a neuropathologically distinct, clinically heterogeneous variant of frontotemporal dementia (FTD) that may include parkinsonism or MND.
Full summary, score breakdown and related studies → Original source
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2004-10-01
Barriers to excellent end-of-life care for patients with dementia
45/100 ✓ Peer-reviewed Caregiving Journal of general internal medicine
Key finding: While great strides have been made recently in improving end-of-life care in the United States, people with dementia often die with inadequate pain control, with feeding tubes in place, and without the benefits of hospice care. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-10-01
Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia
46/100 ✓ Peer-reviewed Brain scans and imaging The American journal of clinical nutrition
Key finding: Light-to-moderate alcohol intake is associated with a lower prevalence of vascular brain findings and, in APOE epsilon4 carriers, hippocampal and amygdalar atrophy on MRI. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-10-01
The relationship between brain structure and neurocognition in schizophrenia: a selective review
41/100 ✓ Peer-reviewed Getting a diagnosis Schizophrenia research
Key finding: The review revealed that whole brain volume tends to correlate with the measures of general intelligence as well as with a range of specific cognitive functions in normal controls and female schizophrenia patients, but this relationship is disrupted in male patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-10-01
Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
53/100 ✓ Peer-reviewed Genetics Neurology
Key finding: The authors identified 40 PCA cases. +1 more finding
Full summary, score breakdown and related studies → Original source
September 2004 19
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2004-09-30
RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier
47/100 ✓ Peer-reviewed Inflammation and the immune system Stroke
Key finding: Whether Abeta-related pathology in the CNS is reversible or not and what key therapeutic targets are controlling Abeta/amyloid levels in the aging brain remain debatable. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-30
Amyloid angiopathy-related vascular cognitive impairment
50/100 ✓ Peer-reviewed Brain tissue and pathology Stroke
Key finding: The two population-based autopsy studies that have analyzed cognitive status during life as a function of CAA have each suggested deleterious effects of CAA on cognition even after controlling for age and Alzheimer disease pathology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-27
Spatial memory, recognition memory, and the hippocampus
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: These findings show that the hippocampus is important for both spatial memory and recognition memory.
Full summary, score breakdown and related studies → Original source
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2004-09-21
Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia
56/100 ✓ Peer-reviewed Caregiving Health and quality of life outcomes
Key finding: Dependency upon others to perform ADL was the main factor affecting HRQoL. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-09-15
Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease
45/100 ✓ Peer-reviewed Hippocampus size on brain scans Cerebral cortex (New York, N.Y. : 1991)
Key finding: Group-level analyses revealed that nondemented age-related differences were greater in anterior than posterior callosal regions and were not augmented by early-stage AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-13
Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
36/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America
Key finding: This pathology indicates that Cp and Heph are critical for CNS iron homeostasis and that loss of Cp and Heph in the mouse leads to age-dependent retinal neurodegeneration, providing a model that can be used to test the therapeutic efficacy of iron chelators and antiangiogenic agents.
Full summary, score breakdown and related studies → Original source
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2004-09-09
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex
36/100 ✓ Peer-reviewed Drug development The Journal of pharmacology and experimental therapeutics
Key finding: These studies revealed 15 genes involved in cell growth and signaling and trafficking that were similarly changed by all three statins. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
REM Sleep Behavior Disorder in Parkinson’s Disease and Dementia with Lewy Bodies
36/100 ✓ Peer-reviewed Brain scans and imaging Journal of Geriatric Psychiatry and Neurology
Key finding: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
Motor signs during the course of Alzheimer disease
56/100 ✓ Peer-reviewed Costs and economics Neurology
Key finding: Most motor signs occur frequently and progress rapidly in Alzheimer disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
Deciphering the molecular basis of memory failure in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: Experiments in rodents suggest that soluble oligomers of the amyloid beta protein (Abeta) may discretely interfere with synaptic mechanisms mediating aspects of learning and memory, including long-term potentiation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-09-01
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
36/100 ✓ Peer-reviewed Prevention and risk Neuron
Key finding: High DHA consumption is associated with reduced Alzheimer's disease (AD) risk, yet mechanisms and therapeutic potential remain elusive. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
The Informant Questionnaire on cognitive decline in the elderly (IQCODE): a review
57/100 ✓ Peer-reviewed Risk factors International psychogeriatrics
Key finding: Because the IQCODE provides information complementary to brief cognitive tests, harnessing them together can improve screening accuracy.
Full summary, score breakdown and related studies → Original source
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2004-09-01
Techniques to study amyloid fibril formation in vitro
36/100 ✓ Peer-reviewed Risk factors Methods (San Diego, Calif.)
Key finding: Amyloid fibrils are ordered aggregates of peptides or proteins that are fibrillar in structure and contribute to the complications of many diseases (e.g., type 2 diabetes mellitus, Alzheimer's disease, and primary systemic amyloidosis). +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
Pharmacological inhibitors of glycogen synthase kinase 3
36/100 ✓ Peer-reviewed Risk factors Trends in pharmacological sciences
Key finding: A large body of evidence supports speculation that pharmacological inhibitors of GSK-3 could be used to treat several diseases, including Alzheimer's disease and other neurodegenerative diseases, bipolar affective disorder, diabetes, and diseases caused by unicellular parasites that express GSK-3 homologues. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
40/100 ✓ Peer-reviewed Drug development The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Collectively, these results suggest a role for caspase-6 and N-terminal truncation of tau during neurofibrillary tangle evolution and the progression of Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2004-09-01
Strategies for disease modification in Alzheimer's disease
36/100 ✓ Peer-reviewed Treatments Nature reviews. Neuroscience
Key finding: Treating Alzheimer's disease (AD) is the biggest unmet medical need in neurology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: In vitro neuropathological studies and behavioral measures in a canine model of aging previously suggested that the frontal lobes of the dog might be sensitive to aging. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-09-01
Smaller hippocampal volume in Dutch police officers with posttraumatic stress disorder
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: We confirmed previous findings of smaller hippocampal volume in PTSD in a new population made up of police officers, excluding comorbidity as a confounder. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-09-01
Methods for assessment of cognitive failure and delirium in palliative care patients: implications for practice and research
36/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Ten different instruments were used: The Mini Mental State Exam was used in 13 studies. +4 more findings
Full summary, score breakdown and related studies → Original source
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