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Detecting depression in Alzheimer's disease: evaluation of four different scales
Müller-Thomsen T, Arlt S, Mann U, Mass R, Ganzer S.. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2005-03-01
Topic: Amyloid, tau and blood-test diagnosis
Depression is a frequent condition in Alzheimer's disease (AD). The prevalence of depressive symptoms depends on the severity of dementia and the instruments used. Our aim was to assess the prevalence of depression dependent on the severity of dementia by four different scales: The 15-point Geriatric Depression Scale (GDS), the Montgomery and Asperg Depression Scale (MADRS), the Cornell Scale for Depression in Dementia (CSDD) and the Nurses Observation Scale for Geriatric Patients (NOSGER).
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APA 7th
Müller-Thomsen, T., Arlt, S., Mann, U., Mass, R., & Ganzer, S. (2005). Detecting depression in Alzheimer's disease: evaluation of four different scales. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. https://doi.org/10.1016/j.acn.2004.03.010
Vancouver
Müller-Thomsen T, Arlt S, Mann U, Mass R, Ganzer S. Detecting depression in Alzheimer's disease: evaluation of four different scales. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2005. doi:10.1016/j.acn.2004.03.010. PMID: 15708735.
BibTeX
@article{mullerthomsen2005-15708735,
author = {Müller-Thomsen, T. and Arlt, S. and Mann, U. and Mass, R. and Ganzer, S.},
title = {{Detecting depression in Alzheimer's disease: evaluation of four different scales}},
journal = {Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists},
year = {2005},
doi = {10.1016/j.acn.2004.03.010},
pmid = {15708735},
url = {https://doi.org/10.1016/j.acn.2004.03.010}
}
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Key findings
- The prevalence of depressive symptoms depends on the severity of dementia and the instruments used.
- Our aim was to assess the prevalence of depression dependent on the severity of dementia by four different scales: The 15-point Geriatric Depression Scale (GDS), the Montgomery and Asperg Depression Scale (MADRS), the Cornell Scale for Depression in Dementia (CSDD) and the Nurses Observation Scale for Geriatric Patients (NOSGER).
- The study population consisted of 316 patients with Alzheimer's disease from a psychiatric out-patients memory-clinic, which was divided into two groups: mild AD (Mini-Mental Status Examination (MMSE) > or = 18) and moderate to severe AD (MMSE <18).
- Additionally, internal consistency and correlation of these scales were calculated.
Why it matters
This study compared four scales for detecting depression in people with Alzheimer's disease. It is about measuring depression, not about treating, curing or preventing Alzheimer's disease.
Study details
- Participants316
- Effect size53.4%; 68.4%
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists) |
| Journal's citation record | 2 / 4 | Archives of Clinical Neuropsychology: journal h-index 151 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 2 / 4 | 316 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 169 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.3 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 3 / 6 | Cited 3.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Stefanie Ganzer: h-index 10 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University Medical Center Hamburg-Eppendorf: institution h-index 736 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15708735) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
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