Newest studies

The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders

46/100 ✓ Peer-reviewed Prevention and risk Progress in neurobiology

Key finding: The concept of 'cognitive reserve', and a broader theory of 'brain reserve', were originally proposed to help explain epidemiological data indicating that individuals who engaged in higher levels of mental and physical activity via education, occupation and recreation, were at lower risk of developing Alzheimer's disease and other forms of dementia. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort

70/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: We have demonstrated that three baseline measures, namely, age >or=72 years, semantic fluency less than 20 words in 90 s and inability to copy an intersecting pentagons figure, are significant predictors of dementia risk, thus validating our previous findings. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia

67/100 ✓ Peer-reviewed Prevention and risk The Cochrane database of systematic reviews

Key finding: Main results Four trials including 15,936 hypertensive subjects were identified. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

LEAP: learning embeddings for atlas propagation

48/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage

Key finding: A manifold is learned from a coordinate system embedding that allows the identification of neighborhoods which contain images that are similar based on a chosen criterion. +3 more findings

Full summary, score breakdown and related studies → Original source

The aftermath of hip fracture: discharge placement, functional status change, and mortality

40/100 ✓ Peer-reviewed Disparities American journal of epidemiology

Key finding: Hip fracture characteristics, socioeconomic status, and year of fracture were significantly associated with discharge placement. +1 more finding

Full summary, score breakdown and related studies → Original source

AddNeuroMed—The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease

36/100 ✓ Peer-reviewed Genetics Annals of the New York Academy of Sciences

Key finding: The experience of AddNeuroMed leads us to three overall conclusions.

• Biomarkers

Full summary, score breakdown and related studies → Original source

The clinical course of advanced dementia

46/100 ✓ Peer-reviewed Health systems and care delivery The New England journal of medicine

Key finding: Pneumonia, febrile episodes, and eating problems are frequent complications in patients with advanced dementia, and these complications are associated with high 6-month mortality rates. +1 more finding

• Care Services

Full summary, score breakdown and related studies → Original source

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases

40/100 ✓ Peer-reviewed Disease mechanisms Human molecular genetics

Key finding: As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial dysfunction often have a neurodegenerative component. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Anemia or low hemoglobin levels preceding Parkinson disease: a case-control study

62/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Our results support an association between anemia experienced early in life and the later development of Parkinson disease. +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

40/100 ✓ Peer-reviewed Risk factors The Journal of cell biology

Key finding: Glyburide analogues inhibit ATP- but not hypothermia-induced IL-1beta secretion from human monocytes expressing familial cold-associated autoinflammatory syndrome-associated Cryopyrin mutations, thus suggesting that inhibition occurs upstream of Cryopyrin. +1 more finding

Full summary, score breakdown and related studies → Original source

Essential tremor--neurodegenerative or nondegenerative disease towards a working definition of ET

40/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society

Key finding: Essential tremor (ET) is a syndrome of tremor in posture and movement, but recent studies have revealed additional cerebellar motor disturbances, cognitive disturbances, personality changes, hearing loss, and olfactory deficits. +2 more findings

Full summary, score breakdown and related studies → Original source

Risk factors for dementia

36/100 ✓ Peer-reviewed Prevention trials Journal of the Formosan Medical Association = Taiwan yi zhi

Key finding: In Taiwan, the prevalence of dementia for people aged > or = 65 years was 2-4% by 2000. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

36/100 ✓ Peer-reviewed Clinical trials Nature reviews. Drug discovery

Key finding: The recent failure of amyloid-beta-targeted therapeutics in Phase III clinical trials suggests that it is timely and prudent to consider alternative drug discovery strategies for Alzheimer's disease.

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease

36/100 ✓ Peer-reviewed Drug development The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Consistently, we found a very rapid activation of p21(ras) in vivo in the substantia nigra pars compacta of MPTP-intoxicated mice. +3 more findings

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Disruption of functional connectivity in clinically normal older adults harboring amyloid burden

43/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Clinically normal participants with high amyloid burden displayed significantly reduced functional correlations within the default network relative to participants with low amyloid burden. +1 more finding

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Genome-wide association studies in Alzheimer's disease

36/100 ✓ Peer-reviewed Genetics Human molecular genetics

Key finding: On the basis of the data available at the time of this writing, the most compelling novel GWAS signal has been observed in GAB2 (GRB2-associated binding protein 2), followed by less consistently replicated signals in galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology

40/100 ✓ Peer-reviewed End-of-life care Neurology

Key finding: The authors identified 2 Class I studies, 8 Class II studies, and 30 Class III studies in ALS, but many important areas have been little studied.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization

36/100 ✓ Peer-reviewed Clinical safety Biochemistry

Key finding: These findings support the notion that while both the location and hydrophobicity of protein segments are important elements that affect the propensity to form amyloid fibrils, the intrinsic ability of a polypeptide to fold structurally into amyloid is also critical.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Impact of a comanaged Geriatric Fracture Center on short-term hip fracture outcomes

48/100 ✓ Peer-reviewed Clinical safety Archives of internal medicine

Key finding: Comanagement by geriatricians and orthopedic surgeons, combined with standardized care, leads to improved processes and outcomes for patients with hip fractures. +3 more findings

Full summary, score breakdown and related studies → Original source

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Fluorescence resonance energy transfer analysis revealed colocalization of cofilin-GFP (green fluorescent protein) and pMAP in rods, suggesting their close proximity within a cytoskeletal inclusion complex. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Chronic Kidney Disease Is a Potential Risk Factor for the Development of Purple Urine Bag Syndrome

45/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: As they mix together, they become purple.2 According to a few previous reports, PUBS often occurred in elderly women who are bedridden, chronically catheterized, and constipated.3 In addition, PUBS was found in alkaline urine and with higher bacterial counts.3,4 Because of lack of significant patient numbers, the clinical background, underlining diseases, urinanalysis, and incidence of PUBS have not been well documented. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling

46/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: However, NFAT signaling in AD remains relatively uninvestigated. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Low sensitivity in clinical diagnoses of dementia with Lewy bodies

54/100 ✓ Peer-reviewed Long-term cohort studies Journal of neurology

Key finding: Relatively few prior studies have been performed on large, multicenter-derived datasets to test the accuracy of final clinical ND diagnoses in relation to definitive neuropathological findings. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

CSF biomarkers predict rate of cognitive decline in Alzheimer disease

52/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: CSF biomarkers amyloid beta 1-42 (Abeta(42)), total tau (tau), and tau phosphorylated at threonine 181 (p-tau-181) are useful diagnostic markers for Alzheimer disease (AD). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

52/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Accumulation of alpha-syn in these patients might be associated with alterations in the autophagy pathway. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source