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Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease
Vogel A, Hasselbalch SG, Gade A, Ziebell M, Waldemar G.. International journal of geriatric psychiatry, 2005-03-01
Topic: Amyloid, tau and blood-test diagnosis
Objectives To investigate the correlation between anosognosia and behavioural symptoms, performance on executive tests, and frontal cortex regional cerebral blood flow (rCBF) in patients with 'amnestic mild cognitive impairment' (MCI) and mild Alzheimer's disease (AD). Methods From a prospective Memory Clinic cohort including consecutively referred patients, age 60 years or above, and with MMSE score 20 or above, 36 patients with AD and 30 with MCI were included in this study. Anosognosia was assessed using a categorical scale and discrepancy scores between patients' and relatives' reports on a 20-item Memory Questionnaire (MQ).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Vogel, A., Hasselbalch, S. G., Gade, A., Ziebell, M., & Waldemar, G. (2005). Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease. International journal of geriatric psychiatry. https://doi.org/10.1002/gps.1272
Vancouver
Vogel A, Hasselbalch SG, Gade A, Ziebell M, Waldemar G. Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease. International journal of geriatric psychiatry. 2005. doi:10.1002/gps.1272. PMID: 15717342.
BibTeX
@article{vogel2005-15717342,
author = {Vogel, A. and Hasselbalch, S. G. and Gade, A. and Ziebell, M. and Waldemar, G.},
title = {{Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease}},
journal = {International journal of geriatric psychiatry},
year = {2005},
doi = {10.1002/gps.1272},
pmid = {15717342},
url = {https://doi.org/10.1002/gps.1272}
}
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Key findings
- Methods From a prospective Memory Clinic cohort including consecutively referred patients, age 60 years or above, and with MMSE score 20 or above, 36 patients with AD and 30 with MCI were included in this study.
- Anosognosia was assessed using a categorical scale and discrepancy scores between patients' and relatives' reports on a 20-item Memory Questionnaire (MQ).
- Behavioural symptoms were assessed with Frontal Behavioural Inventory (FBI).
- Executive functions were examined with a range of neuropsychological tests.
Why it matters
This study examined the relationship between unawareness of memory problems (anosognosia) and behavioral symptoms, executive test performance, and frontal cortex blood flow in 36 patients with Alzheimer's disease and 30 with mild cognitive impairment. It describes a clinical feature of the disease and does not test any treatment, cure, or prevention.
Study details
- Participants36
- Evidence strengthModerate
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of geriatric psychiatry) |
| Journal's citation record | 2 / 4 | International Journal of Geriatric Psychiatry: journal h-index 190 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 1 / 4 | 36 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 160 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.0 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 3 / 6 | Cited 4.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Gunhild Waldemar: h-index 80 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Copenhagen: institution h-index 1,378 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15717342) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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