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Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B
Julie C. Price, William E. Klunk, Brian J. Lopresti, Xueling Lu, Jessica A. Hoge, Scott K. Ziolko, Daniel P. Holt, CAROLYN CIDIS MELTZER, Steven T. DeKosky, Chester A. Mathis. Journal of Cerebral Blood Flow & Metabolism, 2005-06-09
Topic: Amyloid, tau and blood-test diagnosis
A valid quantitative imaging method for the measurement of amyloid deposition in humans could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our group developed Pittsburgh Compound-B (PIB), an amyloid-binding radiotracer, for positron emission tomography (PET). The current study was aimed to further validate PIB PET through quantitative imaging (arterial input) and inclusion of subjects with mild cognitive impairment (MCI). Pittsburgh Compound-B studies were performed in five AD, five MCI, and five control subjects and five subjects were retested within 20 days. Magnetic resonance images were acquired for partial volume correction and region-of-interest definition (e.g., posterior cingulate: PCG; cerebellum: CER). Data were analyzed using compartmental and graphical approaches. Regional distribution volume (DV) values were normalized to the reference region (CER) to yield DV ratios (DVRs). Good agreement was observed between compartmental and Logan DVR values (e.g., PCG: r=0.89, slope=0.91); the Logan results were less variable. Nonspecific PIB retention was similar across subjects (n=15, Logan CER DV: 3.63+/-0.48). Greater retention was observed in AD cortical areas, relative to controls (P<0.05). The PIB retention in MCI subjects appeared either 'AD-like' or 'control-like'. The mean test/retest variation was approximately 6% in primary areas-of-interest. The Logan analysis was the method-of-choice for the PIB PET data as it proved stable, valid, and promising for future larger studies and voxel-based statistical analyses. This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum.
Why it matters
Tested quantitative PET imaging with Pittsburgh Compound-B (PIB), an amyloid-binding tracer, in five people with Alzheimer's disease, five with mild cognitive impairment, and five controls. Retention was greater in Alzheimer's cortical areas than in controls, people with mild cognitive impairment looked either 'AD-like' or 'control-like', and the authors found the Logan analysis method stable and valid.
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How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 44 of the 95 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Cerebral Blood Flow & Metabolism) |
| Journal's citation record | 3 / 4 | Journal of Cerebral Blood Flow & Metabolism: journal h-index 285 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 722 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 31.4 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 4 / 6 | Cited 19.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 38 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Chester A. Mathis: h-index 105 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Pittsburgh: institution h-index 1,470 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15944649) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 44 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 44 of the 95 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 10 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Price, J. C., Klunk, W. E., Lopresti, B. J., Lu, X., Hoge, J. A., Ziolko, S. K., et al. (2005). Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/sj.jcbfm.9600146
Vancouver
Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, et al. Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B. Journal of Cerebral Blood Flow & Metabolism. 2005. doi:10.1038/sj.jcbfm.9600146. PMID: 15944649.
BibTeX
@article{price2005-15944649,
author = {Price, Julie C. and Klunk, William E. and Lopresti, Brian J. and Lu, Xueling and Hoge, Jessica A. and Ziolko, Scott K. and Holt, Daniel P. and MELTZER, CAROLYN CIDIS and DeKosky, Steven T. and Mathis, Chester A.},
title = {{Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B}},
journal = {Journal of Cerebral Blood Flow \& Metabolism},
year = {2005},
doi = {10.1038/sj.jcbfm.9600146},
pmid = {15944649},
url = {https://doi.org/10.1038/sj.jcbfm.9600146}
}
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