Home › Research › Treatments
Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study
Bernard M. Ravina. Journal of Neurology Neurosurgery & Psychiatry, 2005-06-18
Topic: Drug trials: efficacy and safety
Donepezil was well tolerated and most adverse events were mild. There was no worsening of PD symptoms as measured by the total or motor sections of the Unified Parkinson's Disease Rating Scale.There was a 1.9 point trend toward better scores on the ADAScog on treatment compared with placebo that was not statistically significant. The secondary cognitive measures showed a statistically significant 2 point benefit on the Mini Mental Status Examination and no change on the Mattis Dementia Rating Scale (MDRS). The Clinical Global Impression of Change (CGI) showed a significant 0.37 point improvement on donepezil. No improvement was observed on the MDRS or the Brief Psychiatric Rating Scale. Carryover between treatment periods was observed but was not statistically significant. Donepezil was well tolerated and did not worsen PD. There may be a modest benefit on aspects of cognitive function. The possible clinical benefit measured by CGI was reflected in only one of the cognitive scales used in this study.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ravina, B. M. (2005). Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study. Journal of Neurology Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.2004.050682
Vancouver
Ravina BM. Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study. Journal of Neurology Neurosurgery & Psychiatry. 2005. doi:10.1136/jnnp.2004.050682. PMID: 15965198.
BibTeX
@article{ravina2005-15965198,
author = {Ravina, Bernard M.},
title = {{Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study}},
journal = {Journal of Neurology Neurosurgery \& Psychiatry},
year = {2005},
doi = {10.1136/jnnp.2004.050682},
pmid = {15965198},
url = {https://doi.org/10.1136/jnnp.2004.050682}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Donepezil was well tolerated and most adverse events were mild.
- There was no worsening of PD symptoms as measured by the total or motor sections of the Unified Parkinson's Disease Rating Scale.There was a 1.9 point trend toward better scores on the ADAScog on treatment compared with placebo that was not statistically significant.
- The secondary cognitive measures showed a statistically significant 2 point benefit on the Mini Mental Status Examination and no change on the Mattis Dementia Rating Scale (MDRS).
- The Clinical Global Impression of Change (CGI) showed a significant 0.37 point improvement on donepezil.
- No improvement was observed on the MDRS or the Brief Psychiatric Rating Scale.
New to this subject? Start with our plain-English guide: Treatments →
Study details
- Participants22
- Evidence strengthHigh
How this study scored 57/100
Published in a peer-reviewed journal. Scored zero for study design and effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 33 of the 58 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Neurology Neurosurgery & Psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 1 / 4 | 22 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 2 / 2 | Randomised and blinded or placebo-controlled (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15965198) |
| Free to read | 2 / 2 | Free to read |
| Points | 33 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 33 of the 58 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related studies in Treatments
Also tagged “galantamine”
271 studies in the library carry the topic tag “galantamine”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 271 tagged studies.