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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Plain-language summary

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been reported to reduce the risk of Alzheimer disease. We have shown previously that statins inhibit a beta-amyloid (Abeta)-mediated inflammatory response through mechanisms independent of cholesterol reduction. Specifically, statins exert anti-inflammatory actions through their ability to prevent the isoprenylation of members of the Rho family of small G-proteins, resulting in the functional inactivation of these G-proteins.

What this study adds

Evidence grade: Low

This laboratory study reports that statins inhibit a beta-amyloid-mediated inflammatory response in microglia through mechanisms independent of cholesterol reduction. It reports no treatment, cure, or prevention tested in patients.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Cordle, A., Koenigsknecht-Talboo, J., Wilkinson, B., Limpert, A., & Landreth, G. (2005). Mechanisms of statin-mediated inhibition of small G-protein function. The Journal of biological chemistry. https://doi.org/10.1074/jbc.m505268200

Vancouver

Cordle A, Koenigsknecht-Talboo J, Wilkinson B, Limpert A, Landreth G. Mechanisms of statin-mediated inhibition of small G-protein function. The Journal of biological chemistry. 2005. doi:10.1074/jbc.m505268200. PMID: 16085653.

BibTeX

@article{cordle2005-16085653,
  author  = {Cordle, A. and Koenigsknecht-Talboo, J. and Wilkinson, B. and Limpert, A. and Landreth, G.},
  title   = {{Mechanisms of statin-mediated inhibition of small G-protein function}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m505268200},
  pmid    = {16085653},
  url     = {https://doi.org/10.1074/jbc.m505268200}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

We have shown previously that statins inhibit a beta-amyloid (Abeta)-mediated inflammatory response through mechanisms independent of cholesterol reduction.
Specifically, statins exert anti-inflammatory actions through their ability to prevent the isoprenylation of members of the Rho family of small G-proteins, resulting in the functional inactivation of these G-proteins.
We report that statin treatment of microglia results in perturbation of the cytoskeleton and morphological changes due to alteration in Rho family function.
Statins also block Abeta-stimulated phagocytosis through inhibition of Rac action.

Why it matters

Study details

Evidence strengthLow

How this study scored 45/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of biological chemistry)
Journal's citation record	4 / 4	Journal of Biological Chemistry: journal h-index 780 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2005 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 235 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.2 citations a year over 23 year(s) since 2005
Impact for its field and year	4 / 6	Cited 8.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Gary E. Landreth: h-index 101 (OpenAlex, whole career)
Institution's track record	1 / 3	Case Western Reserve University: institution h-index 1,159 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 16085653)
Free to read	0 / 2	Behind a paywall — scores zero
Total	45 / 100	—

What each of these 20 components measures, and what this score is not →

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